dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Atacho, Diahann A. M. |
dc.contributor.author |
Reynisson, Hallur |
dc.contributor.author |
Pétursdóttir, Anna Þóra |
dc.contributor.author |
Eysteinsson, Thor |
dc.contributor.author |
Steingrimsson, Eirikur |
dc.contributor.author |
Petersen, Petur Henry |
dc.date.accessioned |
2020-08-06T16:17:37Z |
dc.date.available |
2020-08-06T16:17:37Z |
dc.date.issued |
2020-03 |
dc.identifier.citation |
Atacho, D. A. M., Reynisson, H., Petursdottir, A. T., Eysteinsson, T., Steingrimsson, E., & Petersen, P. H. (2020). Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity. 7(2), ENEURO.0412-0419.2020. doi:10.1523/ENEURO.0412-19.2020 %J eneuro |
dc.identifier.issn |
2373-2822 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/1933 |
dc.description |
Publisher's version |
dc.description.abstract |
Neuroplasticity forms the basis for neuronal circuit complexity and differences between otherwise similar circuits. We show that the microphthalmia-associated transcription factor (Mitf) plays a central role in intrinsic plasticity of olfactory bulb (OB) projection neurons. Mitral and tufted (M/T) neurons from Mitf mutant mice are hyperexcitable, have a reduced A-type potassium current (IA) and exhibit reduced expression of Kcnd3, which encodes a potassium voltage-gated channel subunit (Kv4.3) important for generating the IA. Furthermore, expression of the Mitf and Kcnd3 genes is activity dependent in OB projection neurons and the MITF protein activates expression from Kcnd3 regulatory elements. Moreover, Mitf mutant mice have changes in olfactory habituation and have increased habituation for an odorant following long-term exposure, indicating that regulation of Kcnd3 is pivotal for long-term olfactory adaptation. Our findings show that Mitf acts as a direct regulator of intrinsic homeostatic feedback and links neuronal activity, transcriptional changes and neuronal function. |
dc.description.sponsorship |
This work was supported by the Icelandic Research Fund, Rannís Grants 152715-053 and 163068-051 |
dc.format.extent |
ENEURO.0412-19.2020 |
dc.language.iso |
en |
dc.publisher |
Society for Neuroscience |
dc.relation.ispartofseries |
Eneuro;7(2) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Genetics |
dc.subject |
Hyperactivity |
dc.subject |
Intrinsic plasticity |
dc.subject |
Kcnd3 |
dc.subject |
Potassium channel |
dc.subject |
Transcription |
dc.subject |
Erfðafræði |
dc.subject |
Gen |
dc.subject |
Taugafrumur |
dc.title |
Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
dc.description.version |
Peer reviewed |
dc.identifier.journal |
Eneuro |
dc.identifier.doi |
10.1523/ENEURO.0412-19.2020 |
dc.relation.url |
https://syndication.highwire.org/content/doi/10.1523/ENEURO.0412-19.2020 |
dc.contributor.department |
Lífvísindasetur (HÍ) |
dc.contributor.department |
Biomedical Center (UI) |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |