dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Ingadottir, Arora Ros |
dc.contributor.author |
Beck, Anne Marie |
dc.contributor.author |
Baldwin, Christine |
dc.contributor.author |
Weekes, Christine Elizabeth |
dc.contributor.author |
Geirsdottir, Olof |
dc.contributor.author |
Ramel, Alfons |
dc.contributor.author |
Gislason, Thorarinn |
dc.contributor.author |
Gunnarsdottir, Ingibjorg |
dc.date.accessioned |
2020-08-06T13:40:02Z |
dc.date.available |
2020-08-06T13:40:02Z |
dc.date.issued |
2019-01 |
dc.identifier.citation |
Ingadottir AR, Beck AM, Baldwin C, et al. Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial. BMJ Open Resp Res 2019;6:e000349. doi:10.1136/ bmjresp-2018-000349 |
dc.identifier.issn |
2052-4439 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/1927 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Introduction Intervention studies have mainly used oral nutritional supplements (ONS) for the management of patients with chronic obstructive pulmonary disease (COPD) identified as at nutritional risk. In this 12-month randomised feasibility trial, we assessed the (1) feasibility of the recruitment, retention and provision of two interventions: ONS and between-meal snacks (snacks) and (2) the potential impact of the provision of snacks and ONS on body weight and quality of life in patients with COPD.
Methods Hospitalised patients with COPD, at nutritional risk, were randomised to ONS (n=19) or snacks (n=15) providing 600 kcal and 22 g protein a day in addition to regular daily diet. The intervention started in hospital and was continued for 12 months after discharge from the hospital.
Results Study recruitment rate was n=34 (45%) and retention rate at 12 months was similar for both groups: n=13 (68%) in the ONS group and n=10 (67%) in the Snacks group. Both groups gained weight from baseline to 12 months (2.3±4.6 kg (p=0.060) in the ONS group and 4.4±6.4 kg (p=0.030) in the Snacks group). The St George’s Respiratory Questionnaire total score improved from baseline to 12 months in both groups (score 3.9±11.0 (p=0.176) in the ONS group and score 8.9±14.1 (p=0.041) in the Snacks group).
Discussion In patients with COPD who are at nutritional risk snacks are at least as feasible and effective as ONS, however, adequately powered trials that take account of the difficulties in recruiting this patient group are required to confirm this effect.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0 |
dc.description.sponsorship |
This paper presents independent research that was supported by the Icelandic Research Fund of the Icelandic Centre for Research (141216-051), the Eimskip University Fund and the Landspitali University Hospital Research Fund. Oral nutritional supplements were partly funded by Nutricia (Icepharma) and between meals by MS Iceland Dairies (Mjólkursamsalan). |
dc.format.extent |
e000349 |
dc.language.iso |
en |
dc.publisher |
BMJ |
dc.relation.ispartofseries |
BMJ Open Respiratory Research;6(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Mataræði |
dc.subject |
Hollusta matar |
dc.subject |
Lungnasjúkdómar |
dc.title |
Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0 |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
BMJ Open Respiratory Research |
dc.identifier.doi |
10.1136/bmjresp-2018-000349 |
dc.relation.url |
https://syndication.highwire.org/content/doi/10.1136/bmjresp-2018-000349 |
dc.contributor.department |
Matvæla- og næringarfræðideild (HÍ) |
dc.contributor.department |
Faculty of Food Science and Nutrition (UI) |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |