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Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Triebner, Kai
dc.contributor.author Accordini, Simone
dc.contributor.author Calciano, Lucia
dc.contributor.author Johannessen, Ane
dc.contributor.author Benediktsdóttir, Bryndís
dc.contributor.author Bifulco, Ersilia
dc.contributor.author Demoly, Pascal
dc.contributor.author Dharmage, Shyamali C.
dc.contributor.author Franklin, Karl A.
dc.contributor.author Garcia-Aymerich, Judith
dc.contributor.author Gullón Blanco, José Antonio
dc.contributor.author Heinrich, Joachim
dc.contributor.author Holm, Mathias
dc.contributor.author Jarvis, Debbie
dc.contributor.author Jõgi, Rain
dc.contributor.author Lindberg, Eva
dc.contributor.author Martínez-Moratalla, Jesús
dc.contributor.author Muniozguren Agirre, Nerea
dc.contributor.author Pin, Isabelle
dc.contributor.author Probst-Hensch, Nicole
dc.contributor.author Raherison, Chantal
dc.contributor.author Sánchez-Ramos, José Luis
dc.contributor.author Schlünssen, Vivi
dc.contributor.author Svanes, Cecilie
dc.contributor.author Hustad, Steinar
dc.contributor.author Leynaert, Bénédicte
dc.contributor.author Gómez Real, Francisco
dc.date.accessioned 2020-05-19T15:26:49Z
dc.date.available 2020-05-19T15:26:49Z
dc.date.issued 2019-02
dc.identifier.citation Triebner, K. et al., 2019. Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS). Maturitas, 120, pp.29–34.
dc.identifier.issn 0378-5122
dc.identifier.uri https://hdl.handle.net/20.500.11815/1819
dc.description Publisher's version (útgefin grein)
dc.description.abstract Objectives: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The effects of HRT on lung function decline, hence lung ageing, have not yet been investigated despite the recognized effects of HRT on other health outcomes. Study design: The population-based multi-centre European Community Respiratory Health Survey provided complete data for 275 oral HRT users at two time points, who were matched with 383 nonusers and analysed with a two-level linear mixed effects regression model. Main outcome measures: We studied whether HRT use was associated with the annual decline in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). Results: Lung function of women using oral HRT for more than five years declined less rapidly than that of nonusers. The adjusted difference in FVC decline was 5.6 mL/y (95%CI: 1.8 to 9.3, p = 0.01) for women who had taken HRT for six to ten years and 8.9 mL/y (3.5 to 14.2, p = 0.003) for those who had taken it for more than ten years. The adjusted difference in FEV1 decline was 4.4 mL/y (0.9 to 8.0, p = 0.02) with treatment from six to ten years and 5.3 mL/y (0.4 to 10.2, p = 0.048) with treatment for over ten years. Conclusions: In this longitudinal population-based study, the decline in lung function was less rapid in women who used HRT, following a dose-response pattern, and consistent when adjusting for potential confounding factors. This may signify that female sex hormones are of importance for lung ageing.
dc.description.sponsorship Kai Triebner has received a postdoctoral fellowship from the University of Bergen. The present analyses are part of a project funded by the Norwegian Research Council (Project No. 228174) as well as part of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), which has received funding from the European Union's Horizon 2020 research and innovation program (Grant No. 633212). The European Commission supported the European Community Respiratory Health Survey, as part of the “Quality of Life” program. Bodies funding the local studies are listed in the online data supplement. The funding sources had no involvement in the conduct of the research and/or preparation of the article, in study design, in the collection, analysis and interpretation of data, in the writing of the report or in the decision to submit the article for publication.
dc.format.extent 29-34
dc.language.iso en
dc.publisher Elsevier BV
dc.relation info:eu-repo/grantAgreement/EC/H2020/633212
dc.relation.ispartofseries Maturitas;120
dc.rights info:eu-repo/semantics/openAccess
dc.subject Obstetrics and Gynaecology
dc.subject Hormone replacement therapy (HRT)
dc.subject Lung function
dc.subject Menopause
dc.subject Reproductive aging
dc.subject Sex hormones
dc.subject Lungu
dc.subject Tíðahvörf
dc.subject Kynhormónar
dc.title Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
dc.description.version Peer Reviewed
dc.identifier.journal Maturitas
dc.identifier.doi 10.1016/j.maturitas.2018.11.007
dc.relation.url https://www.sciencedirect.com/science/article/pii/S0378512218306029?via%3Dihub
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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