Opin vísindi

Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells

Show simple item record

dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Kortesoja, Maarit
dc.contributor.author Karhu, Elina
dc.contributor.author Olafsdottir, Elin Soffia
dc.contributor.author Freysdottir, Jona
dc.contributor.author Hanski, Leena L.
dc.date.accessioned 2020-05-19T13:47:34Z
dc.date.available 2020-05-19T13:47:34Z
dc.date.issued 2019-02-01
dc.identifier.citation Kortesoja, M. et al., 2019. Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells. Free Radical Biology and Medicine, 131, pp.309–317.
dc.identifier.issn 0891-5849
dc.identifier.uri https://hdl.handle.net/20.500.11815/1816
dc.description Publisher's version (útgefin grein)
dc.description.abstract Redox signaling has been established as an essential component of inflammatory responses, and redox active compounds are of interest as potential immunomodulatory agents. Dibenzocyclooctadiene lignans isolated from Schisandra chinensis, a medicinal plant with widespread use in oriental medicine, have been implicated to possess immunomodulatory properties but their effects on the human innate immune system cells have not been described. In this contribution, data are presented on the impact of schisandrin, schisandrin B and schisandrin C on human monocytic cell redox status, as well as their impact on dendritic cell maturation and T cell activation capacity and cytokine production. In THP-1 cells, levels of intracellular reactive oxygen species (ROS) were elevated after 1 h exposure to schisandrin. Schisandrin B and schisandrin C decreased cellular glutathione pools, which is a phenotype previously reported to promote anti-inflammatory functions. Treatment of human primary monocytes with the lignans during their maturation to dendritic cells did not have any effect on the appearance of surface markers HLA-DR and CD86 but schisandrin B and schisandrin C suppressed the secretion of cytokines interleukin (IL)-6, IL-10 and IL-12 by the mature dendritic cells. Dendritic cells maturated in presence of schisandrin C were further cocultured with naïve CD4+ T cells, resulting in reduced IL-12 production. In THP-1 cells, schisandrin B and schisandrin C reduced the IL-6 and IL-12 production triggered by E. coli lipopolysaccharide and IL-12 production induced by an infection with Chlamydia pneumoniae. In conclusion, the studied lignans act as immunomodulatory agents by altering the cytokine secretion, but do not interfere with dendritic cell maturation. And the observed effects may be associated with the ability of the lignans to alter cellular redox status.
dc.description.sponsorship We would like to acknowledge CIMO (The Centre for International Mobility) for a Nordplus- programme grant for EK. Nina Franko, Milka Lohtaja and Krista Virtanen are acknowledged for excellent technical assistance. We would also like to acknowledge Ilkka Miettinen and Lasse Karhu for excellent assistance in data analysis.
dc.format.extent 309-317
dc.language.iso en
dc.publisher Elsevier BV
dc.relation.ispartofseries Free Radical Biology and Medicine;131
dc.rights info:eu-repo/semantics/openAccess
dc.subject Dibenzocyclooctadiene lignans
dc.subject Schisandra chinensis
dc.subject Bólgur
dc.subject Lyfjagerð
dc.subject Lyfjaefnafræði
dc.subject Ónæmiskerfi
dc.title Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
dc.description.version Peer Reviewed
dc.identifier.journal Free Radical Biology and Medicine
dc.identifier.doi 10.1016/j.freeradbiomed.2018.12.019
dc.relation.url https://www.sciencedirect.com/science/article/pii/S0891584918310906?via%3Dihub
dc.contributor.department Lyfjafræðideild (HÍ)
dc.contributor.department Faculty of Pharmaceutical Sciences (UI)
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

Files in this item

This item appears in the following Collection(s)

Show simple item record