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Pathophysiology behind prolonged whiplash associated disorders: study protocol for an experimental study

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Peolsson, Anneli
dc.contributor.author Karlsson, Anette
dc.contributor.author Ghafouri, Bijar
dc.contributor.author Ebbers, Tino
dc.contributor.author Engström, Maria
dc.contributor.author Jönsson, Margaretha
dc.contributor.author Wåhlén, Karin
dc.contributor.author Romu, Thobias
dc.contributor.author Borga, Magnus
dc.contributor.author Kristjansson, Eythor
dc.contributor.author Sarig Bahat, Hilla
dc.contributor.author German, Dmitry
dc.contributor.author Zsigmond, Peter
dc.contributor.author Peterson, Gunnel
dc.date.accessioned 2020-05-18T11:22:36Z
dc.date.available 2020-05-18T11:22:36Z
dc.date.issued 2019-02-02
dc.identifier.citation Peolsson, A., Karlsson, A., Ghafouri, B. et al. Pathophysiology behind prolonged whiplash associated disorders: study protocol for an experimental study. BMC Musculoskeletal Disorders 20, 51 (2019). https://doi.org/10.1186/s12891-019-2433-3
dc.identifier.issn 1471-2474
dc.identifier.uri https://hdl.handle.net/20.500.11815/1810
dc.description Publisher's version (útgefin grein)
dc.description.abstract Background: There is insufficient knowledge of pathophysiological parameters to understand the mechanism behind prolonged whiplash associated disorders (WAD), and it is not known whether or not changes can be restored by rehabilitation. The aims of the projects are to investigate imaging and molecular biomarkers, cervical kinaesthesia, postural sway and the association with pain, disability and other outcomes in individuals with longstanding WAD, before and after a neck-specific exercise intervention. Another aim is to compare individuals with WAD with healthy controls. Methods: Participants are a sub-group (n = 30) of individuals recruited from an ongoing randomized controlled study (RCT). Measurements in this experimental prospective study will be carried out at baseline (before intervention) and at a three month follow-up (end of physiotherapy intervention), and will include muscle structure and inflammation using magnetic resonance imaging (MRI), brain structure and function related to pain using functional MRI (fMRI), muscle function using ultrasonography, biomarkers using samples of blood and saliva, cervical kinaesthesia using the "butterfly test" and static balance test using an iPhone app. Association with other measures (self-reported and clinical measures) obtained in the RCT (e.g. background data, pain, disability, satisfaction with care, work ability, quality of life) may be investigated. Healthy volunteers matched for age and gender will be recruited as controls (n = 30). Discussion: The study results may contribute to the development of improved diagnostics and improved rehabilitation methods for WAD. Trial registration: Clinicaltrial.gov Protocol ID: NCT03664934, initial release 09/11/2018.
dc.description.sponsorship The Swedish Research Council (AP), Östergötland County Council, Sweden (AP) and Sörmland County Council, Sweden (GP). The research is the authors own work independent of the funding agencies. The funding body has no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
dc.format.extent 2433
dc.language.iso en
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartofseries BMC Musculoskeletal Disorders;20(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Biomarkers
dc.subject Chronic
dc.subject Diagnostic imaging
dc.subject Exercise therapy
dc.subject MRI
dc.subject Physiopathology
dc.subject Physiotherapy
dc.subject Sjúkraþjálfun
dc.subject Hálshnykksáverkar
dc.subject Meinafræði
dc.subject Lífeðlisfræði
dc.title Pathophysiology behind prolonged whiplash associated disorders: study protocol for an experimental study
dc.type info:eu-repo/semantics/article
dcterms.license Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.description.version Peer Reviewed
dc.identifier.journal BMC Musculoskeletal Disorders
dc.identifier.doi 10.1186/s12891-019-2433-3
dc.relation.url https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-019-2433-3#citeas
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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