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Mortality of lung cancer as a second primary malignancy: A population‐based cohort study

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Deng, Lei
dc.contributor.author Harðardóttir, Hrönn
dc.contributor.author Song, Huan
dc.contributor.author Xiao, Zhengrui
dc.contributor.author Jiang, Changchuan
dc.contributor.author Wang, Qian
dc.contributor.author Valdimarsdottir, Unnur
dc.contributor.author Cheng, Haiying
dc.contributor.author Loo, Billy W.
dc.contributor.author Lu, Donghao
dc.date.accessioned 2020-04-21T14:21:28Z
dc.date.available 2020-04-21T14:21:28Z
dc.date.issued 2019-04-16
dc.identifier.citation Deng, L, Harðardottír, H, Song, H, et al. Mortality of lung cancer as a second primary malignancy: A population‐based cohort study. Cancer Med. 2019; 8: 3269‐ 3277. https://doi.org/10.1002/cam4.2172
dc.identifier.issn 2045-7634
dc.identifier.uri https://hdl.handle.net/20.500.11815/1730
dc.description Publisher's version (útgefin grein)
dc.description.abstract Lung cancer as a second primary malignancy (lung-2) is increasingly common, but its prognosis is poorly understood. This study aims to examine the overall and cancer-specific survival of patients diagnosed with lung-2 compared to lung-1. Primary lung cancer patients diagnosed from 1988 to 2014 in the Surveillance, Epidemiology, and End Results (SEER) program were included. Lung-2 was identified in patients with a previous diagnosis of nonlung primary malignancy in SEER. Hazard ratios (HRs) of overall and lung cancer-specific mortality were estimated among patients with lung-2 compared to lung-1, adjusting for age and calendar period at diagnosis, sex, race, socioeconomic status, tumor stage, histology, tumor grade, and treatment. A total of 679 541 and 85 758 patients were identified as lung-1 and lung-2, respectively. Compared to lung-1, patients with lung-2 were more likely to be diagnosed at localized stage, with smaller primary tumor, and treated with surgery. Lung-2 patients were at lower risk of lung cancer-specific mortality in the first 5 years (HR, 0.77; 95% CI, 0.76-0.78 at <1 year; HR, 0.87; 95% CI, 0.86-0.89 from 1 to <5 years) but at higher risk thereafter (HR, 1.32; 95% CI, 1.27-1.37 from 5 to 10 years), independent of tumor characteristics and cancer treatment. Similar pattern was found for overall mortality, although the survival benefit was restricted to the first year after diagnosis. Patients diagnosed with lung-2 face a favorable lung cancer-specific survival within the early period after diagnosis. A conservative approach to manage lung-2 solely based on malignancy history is not supported.
dc.description.sponsorship This work was supported by the National Natural Science Foundation of China (Grant Number 81602670); Swedish Research Council (Grant Number 2018‐00648); and West China Hospital Starting Grant (Grant Number 139180012)
dc.format.extent 3269-3277
dc.language.iso en
dc.publisher Wiley
dc.relation.ispartofseries Cancer Medicine;8(6)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Cohort study
dc.subject Lung cancer
dc.subject Mortality
dc.subject Prognosis
dc.subject Second primary
dc.subject Tilviksrannsóknir
dc.subject Lungnakrabbamein
dc.subject Dánartíðni
dc.subject Batahorfur
dc.title Mortality of lung cancer as a second primary malignancy: A population‐based cohort study
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.description.version Peer Reviewed
dc.identifier.journal Cancer Medicine
dc.identifier.doi 10.1002/cam4.2172
dc.relation.url https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.2172
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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