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The effect of maternal immunity on the equine gammaherpesvirus type 2 and 5 viral load and antibody response

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dc.contributor University of Iceland
dc.contributor Háskóli Íslands
dc.contributor.author Thorsteinsdottir, Lilja
dc.contributor.author Jónsdóttir, Sigríður
dc.contributor.author Stefánsdóttir, Sara Björk
dc.contributor.author Andrésdóttir, Valgerður
dc.contributor.author Wagner, Bettina
dc.contributor.author Marti, Eliane
dc.contributor.author Torsteinsdóttir, Sigurbjörg
dc.contributor.author Svansson, Vilhjálmur
dc.date.accessioned 2020-04-20T11:38:08Z
dc.date.available 2020-04-20T11:38:08Z
dc.date.issued 2019-06-21
dc.identifier.citation Thorsteinsdóttir L, Jónsdóttir S, Stefánsdóttir SB, Andrésdóttir V, Wagner B, Marti E, et al. (2019) The effect of maternal immunity on the equine gammaherpesvirus type 2 and 5 viral load and antibody response. PLoS ONE 14(6): e0218576. https://doi.org/10.1371/journal.pone.0218576
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/20.500.11815/1707
dc.description Publisher's version (útgefin grein)
dc.description.abstract Two types of gammaherpesviruses (γEHV) are known to infect horses, EHV-2 and EHV-5. Foals become infected early in life, probably via the upper respiratory tract, despite maternal antibodies. In this study, we analyzed samples from a herd of mares and their foals. The foals were followed from birth to 22 months of age and the dams during the first 6 months postpartum. Blood and nasal swab samples were taken regularly for evaluation of antibody responses, virus isolation and viral load by qPCR. EHV-2 was isolated on day 5, and EHV-5 on day 12, earlier than previously reported. γEHV specific antibodies were not detectable in serum of foals before colostrum intake but peaked a few days after colostrum. Overall, EHV-2 viral load peaked in nasal swab at three to four months of age, paralleled with decline in maternal antibodies, but EHV-5 viral load did not peak until month 12. Maternal antibodies had a notable effect on the viral load and induction of endogenous antibody production. Foals were grouped in two groups depending on the mare’s γEHV specific total IgG levels in serum at birth, group-high and group-low. Group-high had higher levels of maternal γEHV specific total IgG and IgG4/7 for the first 3 months, but when the endogenous production had superseded maternal antibodies, group-low was higher. The maternal antibodies had an effect on the γEHV viral load. Group-low peaked in EHV-2 viral load one month earlier than group-high. These effects were more evident for EHV-5, as there were seven months between the viral load peaks for the groups. The study provides information on how maternal antibody transfer affects γEHV shedding and antibody production in offspring. It also extends our knowledge on the occurrence of EHV-2 and EHV-5 infection in foals during the first two years of life.
dc.description.sponsorship This work was supported by: The Icelandic Research Fund (VS, 130446), The Developmental Fund for Icelandic Horse Breeding (VS, 10190951), The Icelandic Horse Conservation Fund (VS, 10190942).
dc.format.extent e0218576
dc.language.iso en
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartofseries PLOS ONE;14(6)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Horses
dc.subject Gammaherpesvirus
dc.subject Infection
dc.subject Veirusjúkdómar
dc.subject Hestar
dc.subject Áblásturssótt
dc.subject Sýkingar
dc.title The effect of maternal immunity on the equine gammaherpesvirus type 2 and 5 viral load and antibody response
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.version Peer Reviewed
dc.identifier.journal Plos One
dc.identifier.doi 10.1371/journal.pone.0218576
dc.relation.url http://dx.plos.org/10.1371/journal.pone.0218576
dc.contributor.department Lífvísindasetur (HÍ)
dc.contributor.department Biomedical Center (UI)
dc.contributor.department Tilraunastöð í meinafræði að Keldum (HÍ)
dc.contributor.department Institute for Experimental Pathology, Keldur (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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