Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Kilpeläinen, Tuomas O.; Gudnason, Vilmundur

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dc.contributor	Háskóli Íslands
dc.contributor	University of Iceland
dc.contributor.author	Kilpeläinen, Tuomas O.
dc.contributor.author	orcid.org/0000-0001-5696-0084 Gudnason, Vilmundur
dc.date.accessioned	2020-03-20T15:10:30Z
dc.date.available	2020-03-20T15:10:30Z
dc.date.issued	2019-01-22
dc.identifier.citation	Kilpeläinen, T.O., Bentley, A.R., Noordam, R. et al. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications 10, 376 (2019). https://doi.org/10.1038/s41467-018-08008-w
dc.identifier.issn	2041-1723
dc.identifier.uri	https://hdl.handle.net/20.500.11815/1634
dc.description	Publisher's version (útgefin grein)
dc.description.abstract	Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
dc.description.sponsorship	The present work was largely supported by a grant from the US National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (R01HL118305). The full list of acknowledgments appears in the Supplementary Notes 3 and 4.
dc.format.extent	376
dc.language.iso	en
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartofseries	Nature Communications;10(1)
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Genome-wide analyses
dc.subject	Cholesterol
dc.subject	Ancestry
dc.subject	Erfðarannsóknir
dc.subject	Kólesteról
dc.subject	Arfgengi
dc.title	Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
dc.type	info:eu-repo/semantics/article
dcterms.license	Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.description.version	Peer Reviewed
dc.identifier.journal	Nature Communications
dc.identifier.doi	10.1038/s41467-018-08008-w
dc.relation.url	https://www.nature.com/articles/s41467-018-08008-w
dc.contributor.department	Læknadeild (HÍ)
dc.contributor.department	Faculty of Medicine (UI)
dc.contributor.school	Heilbrigðisvísindasvið (HÍ)
dc.contributor.school	School of Health Sciences (UI)