Title: | A meta-analysis of genome-wide association studies identifies multiple longevity genes |
Author: |
... 74 more authors Show all authors |
Date: | 2019-08-14 |
Language: | English |
Scope: | 3669 |
University/Institute: | Háskóli Íslands University of Iceland |
School: | Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) |
Department: | Læknadeild (HÍ) Faculty of Medicine (UI) |
Series: | Nature Communications;10(1) |
ISSN: | 2041-1723 |
DOI: | 10.1038/s41467-019-11558-2 |
Subject: | Ageing; Diseases; Genome-wide association studies; Risk factors; Öldrun; Sjúkdómar; Áhættuþættir; Erfðarannsóknir |
URI: | https://hdl.handle.net/20.500.11815/1567 |
Citation:Deelen, J., Evans, D.S., Arking, D.E. et al. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun 10, 3669 (2019). https://doi.org/10.1038/s41467-019-11558-2
|
|
Abstract:Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity.
|
|
Description:Publisher's version (útgefin grein).
|
|
Rights:Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
|