A meta-analysis of genome-wide association studies identifies multiple longevity genes

Almenn færsla
dc.contributorHáskóli Íslandsen_US
dc.contributorUniversity of Icelanden_US
dc.contributor.authorDeelen, Joris
dc.contributor.authorEvans, Daniel S.
dc.contributor.authorArking, Dan E.
dc.contributor.authorTesi, Niccolò
dc.contributor.authorNygaard, Marianne
dc.contributor.authorLiu, Xiaomin
dc.contributor.authorWojczynski, Mary K.
dc.contributor.authorBiggs, Mary L.
dc.contributor.authorvan der Spek, Ashley
dc.contributor.authorAtzmon, Gil
dc.contributor.authorWare, Erin B.
dc.contributor.authorSarnowski, Chloé
dc.contributor.authorSmith, Albert Vernon
dc.contributor.authorSeppälä, Ilkka
dc.contributor.authorCordell, Heather J.
dc.contributor.authorDose, Janina
dc.contributor.authorAmin, Najaf
dc.contributor.authorArnold, Alice M.
dc.contributor.authorAyers, Kristin L.
dc.contributor.authorBarzilai, Nir
dc.contributor.authorBecker, Elizabeth J.
dc.contributor.authorBeekman, Marian
dc.contributor.authorBlanché, Hélène
dc.contributor.authorChristensen, Kaare
dc.contributor.authorChristiansen, Lene
dc.contributor.authorCollerton, Joanna C.
dc.contributor.authorCubaynes, Sarah
dc.contributor.authorCummings, Steven R.
dc.contributor.authorDavies, Karen
dc.contributor.authorDebrabant, Birgit
dc.contributor.authorDeleuze, Jean-François
dc.contributor.authorDuncan, Rachel
dc.contributor.authorFaul, Jessica D.
dc.contributor.authorFranceschi, Claudio
dc.contributor.authorGalan, Pilar
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorHuisman, Martijn
dc.contributor.authorHurme, Mikko A.
dc.contributor.authorJagger, Carol
dc.contributor.authorJansen, Iris
dc.contributor.authorJylhä, Marja
dc.contributor.authorKähönen, Mika
dc.contributor.authorKarasik, David
dc.contributor.authorKardia, Sharon L. R.
dc.contributor.authorKingston, Andrew
dc.contributor.authorKirkwood, Thomas B. L.
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorLieb, Wolfgang
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorMartin-Ruiz, Carmen
dc.contributor.authorMin, Junxia
dc.contributor.authorNebel, Almut
dc.contributor.authorNewman, Anne B.
dc.contributor.authorNie, Chao
dc.contributor.authorNohr, Ellen A.
dc.contributor.authorOrwoll, Eric S.
dc.contributor.authorPerls, Thomas T.
dc.contributor.authorProvince, Michael A.
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorRaitakari, Olli T.
dc.contributor.authorReinders, Marcel J. T.
dc.contributor.authorRobine, Jean-Marie
dc.contributor.authorRotter, Jerome I.
dc.contributor.authorSebastiani, Paola
dc.contributor.authorSmith, Jennifer
dc.contributor.authorSørensen, Thorkild I. A.
dc.contributor.authorTaylor, Kent D.
dc.contributor.authorUitterlinden, André G.
dc.contributor.authorvan der Flier, Wiesje
dc.contributor.authorvan der Lee, Sven J.
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorvan Heemst, Diana
dc.contributor.authorVaupel, James W.
dc.contributor.authorWeir, David
dc.contributor.authorYe, Kenny
dc.contributor.authorZeng, Yi
dc.contributor.authorZheng, Wanlin
dc.contributor.authorHolstege, Henne
dc.contributor.authorKiel, Douglas P.
dc.contributor.authorLunetta, Kathryn L.
dc.contributor.authorSlagboom, P. Eline
dc.contributor.authorMurabito, Joanne M.
dc.contributor.departmentLæknadeild (HÍ)en_US
dc.contributor.departmentFaculty of Medicine (UI)en_US
dc.contributor.schoolHeilbrigðisvísindasvið (HÍ)en_US
dc.contributor.schoolSchool of Health Sciences (UI)en_US
dc.date.accessioned2020-03-02T13:43:26Z
dc.date.available2020-03-02T13:43:26Z
dc.date.issued2019-08-14
dc.descriptionPublisher's version (útgefin grein).en_US
dc.description.abstractHuman longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity.en_US
dc.description.sponsorshipAlexander von Humboldt-Stiftungen_US
dc.description.versionPeer Revieweden_US
dc.format.extent3669en_US
dc.identifier.citationDeelen, J., Evans, D.S., Arking, D.E. et al. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun 10, 3669 (2019). https://doi.org/10.1038/s41467-019-11558-2en_US
dc.identifier.doi10.1038/s41467-019-11558-2
dc.identifier.issn2041-1723
dc.identifier.journalNature Communicationsen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11815/1567
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofseriesNature Communications;10(1)
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgeingen_US
dc.subjectDiseasesen_US
dc.subjectGenome-wide association studiesen_US
dc.subjectRisk factorsen_US
dc.subjectÖldrunen_US
dc.subjectSjúkdómaren_US
dc.subjectÁhættuþættiren_US
dc.subjectErfðarannsókniren_US
dc.titleA meta-analysis of genome-wide association studies identifies multiple longevity genesen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dcterms.licenseOpen Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US

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