dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Guðmundsson, Ólafur Ó. |
dc.contributor.author |
Walters, G. Bragi |
dc.contributor.author |
Ingason, Andrés |
dc.contributor.author |
Johansson, Stefan |
dc.contributor.author |
Zayats, Tetyana |
dc.contributor.author |
Athanasiu, Lavinia |
dc.contributor.author |
Sonderby, Ida Elken |
dc.contributor.author |
Gústafsson, Ómar |
dc.contributor.author |
Nawaz, Muhammad S. |
dc.contributor.author |
Jónsson, Guðbjörn F. |
dc.contributor.author |
Jonsson, Lina |
dc.contributor.author |
Knappskog, Per-Morten |
dc.contributor.author |
Ingvarsdóttir, Ester |
dc.contributor.author |
Daviðsdóttir, Katrín |
dc.contributor.author |
Djurovic, Srdjan |
dc.contributor.author |
Knudsen, Gun Peggy Strømstad |
dc.contributor.author |
Askeland, Ragna Bugge |
dc.contributor.author |
Haraldsdóttir, Gyða S. |
dc.contributor.author |
Baldursson, Gísli |
dc.contributor.author |
Magnússon, Páll |
dc.contributor.author |
Sigurdsson, Engilbert |
dc.contributor.author |
Gudbjartsson, Daniel |
dc.contributor.author |
Stefansson, Hreinn |
dc.contributor.author |
Andreassen, Ole A. |
dc.contributor.author |
Haavik, Jan |
dc.contributor.author |
Reichborn-Kjennerud, Ted |
dc.contributor.author |
Stefansson, Kari |
dc.date.accessioned |
2020-02-12T14:21:47Z |
dc.date.available |
2020-02-12T14:21:47Z |
dc.date.issued |
2019-10-17 |
dc.identifier.citation |
Gudmundsson, O.O., Walters, G.B., Ingason, A. et al. Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder. Transl Psychiatry 9, 258 (2019). https://doi.org/10.1038/s41398-019-0599-y |
dc.identifier.issn |
2158-3188 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/1530 |
dc.description |
Publisher's version (útgefin grein). |
dc.description.abstract |
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD), schizophrenia and ADHD. The aim of this study is to determine to what extent ADHD shares high risk CNV alleles with schizophrenia and ASD. We compiled 19 neuropsychiatric CNVs and test 14, with sufficient power, for association with ADHD in Icelandic and Norwegian samples. Eight associate with ADHD; deletions at 2p16.3 (NRXN1), 15q11.2, 15q13.3 (BP4 & BP4.5–BP5) and 22q11.21, and duplications at 1q21.1 distal, 16p11.2 proximal, 16p13.11 and 22q11.21. Six of the CNVs have not been associated with ADHD before. As a group, the 19 CNVs associate with ADHD (OR = 2.43, P = 1.6 × 10−21), even when comorbid ASD and schizophrenia are excluded from the sample. These results highlight the pleiotropic effect of the neuropsychiatric CNVs and add evidence for ADHD, ASD and schizophrenia being related neurodevelopmental disorders rather than distinct entities. |
dc.description.sponsorship |
We are grateful to the participants and we thank the staff at the Research
Recruitment Center. We also thank the staff at deCODE genetics core facilities
and all our colleagues for their important contribution to this work. We are
grateful to the Benefit Society for Children with Disabilities (Styrktarfélag
Lamaðra og Fatlaðra; SLF) for their participation. The research leading to these
results has received support from the Innovative Medicines Initiative Joint
Undertaking under grant agreements’ no. 115008 (NEWMEDS) and no. 115300
(EUAIMS), of which resources are composed of EFPIA in-kind contribution and
financial contribution from the European Union’s Seventh Framework
Programme (EU-FP7/2007–2013), from EU-FP7 grants no. 602450
(IMAGEMEND) and no. 502805 (Aggressotype), EU-FP7-People-2011-IAPP grant
no. 286213 (PsychDPC), and The Research Council of Norway (#226971,
229129, 223273, 213694, 248778), the KG Jebsen Stiftelsen (SKGJ-MED-002 and
SKGJ-MED-008), and The South-East Norway Health Authority (#2012–132). |
dc.format.extent |
258 |
dc.language.iso |
en |
dc.publisher |
Springer Science and Business Media LLC |
dc.relation |
info:eu-repo/grantAgreement/EC/FP7/602450 |
dc.relation |
info:eu-repo/grantAgreement/EC/FP7/502805 |
dc.relation |
info:eu-repo/grantAgreement/EC/FP7/286213 |
dc.relation.ispartofseries |
Translational Psychiatry;9(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
ADHD |
dc.subject |
Comparative genomics |
dc.subject |
Genamengi |
dc.subject |
Samanburðarrannsóknir |
dc.subject |
Erfðarannsóknir |
dc.title |
Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction
in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if
changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If
material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain
permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Translational Psychiatry |
dc.identifier.doi |
10.1038/s41398-019-0599-y |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |
dc.contributor.school |
School of Engineering and Natural Sciences (UI) |
dc.contributor.school |
Verkfræði- og náttúruvísindasvið (HÍ) |