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Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Guðmundsson, Ólafur Ó.
dc.contributor.author Walters, G. Bragi
dc.contributor.author Ingason, Andrés
dc.contributor.author Johansson, Stefan
dc.contributor.author Zayats, Tetyana
dc.contributor.author Athanasiu, Lavinia
dc.contributor.author Sonderby, Ida Elken
dc.contributor.author Gústafsson, Ómar
dc.contributor.author Nawaz, Muhammad S.
dc.contributor.author Jónsson, Guðbjörn F.
dc.contributor.author Jonsson, Lina
dc.contributor.author Knappskog, Per-Morten
dc.contributor.author Ingvarsdóttir, Ester
dc.contributor.author Daviðsdóttir, Katrín
dc.contributor.author Djurovic, Srdjan
dc.contributor.author Knudsen, Gun Peggy Strømstad
dc.contributor.author Askeland, Ragna Bugge
dc.contributor.author Haraldsdóttir, Gyða S.
dc.contributor.author Baldursson, Gísli
dc.contributor.author Magnússon, Páll
dc.contributor.author Sigurdsson, Engilbert
dc.contributor.author Gudbjartsson, Daniel
dc.contributor.author Stefansson, Hreinn
dc.contributor.author Andreassen, Ole A.
dc.contributor.author Haavik, Jan
dc.contributor.author Reichborn-Kjennerud, Ted
dc.contributor.author Stefansson, Kari
dc.date.accessioned 2020-02-12T14:21:47Z
dc.date.available 2020-02-12T14:21:47Z
dc.date.issued 2019-10-17
dc.identifier.citation Gudmundsson, O.O., Walters, G.B., Ingason, A. et al. Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder. Transl Psychiatry 9, 258 (2019). https://doi.org/10.1038/s41398-019-0599-y
dc.identifier.issn 2158-3188
dc.identifier.uri https://hdl.handle.net/20.500.11815/1530
dc.description Publisher's version (útgefin grein).
dc.description.abstract Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD), schizophrenia and ADHD. The aim of this study is to determine to what extent ADHD shares high risk CNV alleles with schizophrenia and ASD. We compiled 19 neuropsychiatric CNVs and test 14, with sufficient power, for association with ADHD in Icelandic and Norwegian samples. Eight associate with ADHD; deletions at 2p16.3 (NRXN1), 15q11.2, 15q13.3 (BP4 & BP4.5–BP5) and 22q11.21, and duplications at 1q21.1 distal, 16p11.2 proximal, 16p13.11 and 22q11.21. Six of the CNVs have not been associated with ADHD before. As a group, the 19 CNVs associate with ADHD (OR = 2.43, P = 1.6 × 10−21), even when comorbid ASD and schizophrenia are excluded from the sample. These results highlight the pleiotropic effect of the neuropsychiatric CNVs and add evidence for ADHD, ASD and schizophrenia being related neurodevelopmental disorders rather than distinct entities.
dc.description.sponsorship We are grateful to the participants and we thank the staff at the Research Recruitment Center. We also thank the staff at deCODE genetics core facilities and all our colleagues for their important contribution to this work. We are grateful to the Benefit Society for Children with Disabilities (Styrktarfélag Lamaðra og Fatlaðra; SLF) for their participation. The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreements’ no. 115008 (NEWMEDS) and no. 115300 (EUAIMS), of which resources are composed of EFPIA in-kind contribution and financial contribution from the European Union’s Seventh Framework Programme (EU-FP7/2007–2013), from EU-FP7 grants no. 602450 (IMAGEMEND) and no. 502805 (Aggressotype), EU-FP7-People-2011-IAPP grant no. 286213 (PsychDPC), and The Research Council of Norway (#226971, 229129, 223273, 213694, 248778), the KG Jebsen Stiftelsen (SKGJ-MED-002 and SKGJ-MED-008), and The South-East Norway Health Authority (#2012–132).
dc.format.extent 258
dc.language.iso en
dc.publisher Springer Science and Business Media LLC
dc.relation info:eu-repo/grantAgreement/EC/FP7/602450
dc.relation info:eu-repo/grantAgreement/EC/FP7/502805
dc.relation info:eu-repo/grantAgreement/EC/FP7/286213
dc.relation.ispartofseries Translational Psychiatry;9(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject ADHD
dc.subject Comparative genomics
dc.subject Genamengi
dc.subject Samanburðarrannsóknir
dc.subject Erfðarannsóknir
dc.title Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder
dc.type info:eu-repo/semantics/article
dcterms.license Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.description.version Peer Reviewed
dc.identifier.journal Translational Psychiatry
dc.identifier.doi 10.1038/s41398-019-0599-y
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)
dc.contributor.school School of Engineering and Natural Sciences (UI)
dc.contributor.school Verkfræði- og náttúruvísindasvið (HÍ)

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