dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Noordam, Raymond |
dc.contributor.author |
Bos, Maxime M. |
dc.contributor.author |
Wang, Heming |
dc.contributor.author |
Winkler, Thomas W. |
dc.contributor.author |
Bentley, Amy R. |
dc.contributor.author |
Kilpeläinen, Tuomas O. |
dc.contributor.author |
de Vries, Paul S. |
dc.contributor.author |
Sung, Yun Ju |
dc.contributor.author |
Schwander, Karen |
dc.contributor.author |
Cade, Brian E. |
dc.contributor.author |
Manning, Alisa |
dc.contributor.author |
Aschard, Hugues |
dc.contributor.author |
Brown, Michael R. |
dc.contributor.author |
Chen, Han |
dc.contributor.author |
Franceschini, Nora |
dc.contributor.author |
Musani, Solomon K. |
dc.contributor.author |
Richard, Melissa |
dc.contributor.author |
Vojinovic, Dina |
dc.contributor.author |
Aslibekyan, Stella |
dc.contributor.author |
Bartz, Traci M. |
dc.contributor.author |
de las Fuentes, Lisa |
dc.contributor.author |
Feitosa, Mary |
dc.contributor.author |
Horimoto, Andrea R. |
dc.contributor.author |
Ilkov, Marjan |
dc.contributor.author |
Kho, Minjung |
dc.contributor.author |
Kraja, Aldi |
dc.contributor.author |
Li, Changwei |
dc.contributor.author |
Lim, Elise |
dc.contributor.author |
Liu, Yongmei |
dc.contributor.author |
Mook-Kanamori, Dennis O. |
dc.contributor.author |
Rankinen, Tuomo |
dc.contributor.author |
Tajuddin, Salman M. |
dc.contributor.author |
van der Spek, Ashley |
dc.contributor.author |
Wang, Zhe |
dc.contributor.author |
Marten, Jonathan |
dc.contributor.author |
Laville, Vincent |
dc.contributor.author |
Alver, Maris |
dc.contributor.author |
Evangelou, Evangelos |
dc.contributor.author |
Graff, Maria E. |
dc.contributor.author |
He, Meian |
dc.contributor.author |
Kühnel, Brigitte |
dc.contributor.author |
Lyytikäinen, Leo-Pekka |
dc.contributor.author |
Marques-Vidal, Pedro |
dc.contributor.author |
Nolte, Ilja M. |
dc.contributor.author |
Palmer, Nicholette D. |
dc.contributor.author |
Rauramaa, Rainer |
dc.contributor.author |
Shu, Xiao-Ou |
dc.contributor.author |
Snieder, Harold |
dc.contributor.author |
Weiss, Stefan |
dc.contributor.author |
Wen, Wanqing |
dc.contributor.author |
Yanek, Lisa R. |
dc.contributor.author |
Adolfo, Correa |
dc.contributor.author |
Ballantyne, Christie |
dc.contributor.author |
Bielak, Larry |
dc.contributor.author |
Biermasz, Nienke R. |
dc.contributor.author |
Boerwinkle, Eric |
dc.contributor.author |
Dimou, Niki |
dc.contributor.author |
Eiriksdottir, Gudny |
dc.contributor.author |
Gao, Chuan |
dc.contributor.author |
Gharib, Sina A. |
dc.contributor.author |
Gottlieb, Daniel J. |
dc.contributor.author |
Haba-Rubio, José |
dc.contributor.author |
Harris, Tamara B. |
dc.contributor.author |
Heikkinen, Sami |
dc.contributor.author |
Heinzer, Raphaël |
dc.contributor.author |
Hixson, James E. |
dc.contributor.author |
Homuth, Georg |
dc.contributor.author |
Ikram, M. Arfan |
dc.contributor.author |
Komulainen, Pirjo |
dc.contributor.author |
Krieger, Jose E. |
dc.contributor.author |
Lee, Jiwon |
dc.contributor.author |
Liu, Jingmin |
dc.contributor.author |
Lohman, Kurt K. |
dc.contributor.author |
Luik, Annemarie I. |
dc.contributor.author |
Mägi, Reedik |
dc.contributor.author |
Martin, Lisa W. |
dc.contributor.author |
Meitinger, Thomas |
dc.contributor.author |
Metspalu, Andres |
dc.contributor.author |
Milaneschi, Yuri |
dc.contributor.author |
Nalls, Mike A. |
dc.contributor.author |
O’Connell, Jeff |
dc.contributor.author |
Peters, Annette |
dc.contributor.author |
Peyser, Patricia |
dc.contributor.author |
Raitakari, Olli T. |
dc.contributor.author |
Reiner, Alex P. |
dc.contributor.author |
Rensen, Patrick C. N. |
dc.contributor.author |
Rice, Treva K. |
dc.contributor.author |
Rich, Stephen S. |
dc.contributor.author |
Roenneberg, Till |
dc.contributor.author |
Rotter, Jerome I. |
dc.contributor.author |
Schreiner, Pamela J. |
dc.contributor.author |
Shikany, James |
dc.contributor.author |
Sidney, Stephen S. |
dc.contributor.author |
Sims, Mario |
dc.contributor.author |
Sitlani, Colleen M. |
dc.contributor.author |
Sofer, Tamar |
dc.contributor.author |
Strauch, Konstantin |
dc.contributor.author |
Swertz, Morris A. |
dc.contributor.author |
Taylor, Kent D. |
dc.contributor.author |
Uitterlinden, André G. |
dc.contributor.author |
van Duijn, Cornelia M. |
dc.contributor.author |
Völzke, Henry |
dc.contributor.author |
Waldenberger, Melanie |
dc.contributor.author |
Wallance, Robert B. |
dc.contributor.author |
van Dijk, Ko Willems |
dc.contributor.author |
Yu, Caizheng |
dc.contributor.author |
Zonderman, Alan B. |
dc.contributor.author |
Becker, Diane M. |
dc.contributor.author |
Elliott, Paul |
dc.contributor.author |
Esko, Tõnu |
dc.contributor.author |
Gieger, Christian |
dc.contributor.author |
Grabe, Hans J. |
dc.contributor.author |
Lakka, Timo A. |
dc.contributor.author |
Lehtimäki, Terho |
dc.contributor.author |
North, Kari E. |
dc.contributor.author |
Penninx, Brenda W. J. H. |
dc.contributor.author |
Vollenweider, Peter |
dc.contributor.author |
Wagenknecht, Lynne E. |
dc.contributor.author |
Wu, Tangchun |
dc.contributor.author |
Xiang, Yong-Bing |
dc.contributor.author |
Zheng, Wei |
dc.contributor.author |
Arnett, Donna K. |
dc.contributor.author |
Bouchard, Claude |
dc.contributor.author |
Evans, Michele K. |
dc.contributor.author |
Gudnason, Vilmundur |
dc.contributor.author |
Kardia, Sharon |
dc.contributor.author |
Kelly, Tanika N. |
dc.contributor.author |
Kritchevsky, Stephen B. |
dc.contributor.author |
Loos, Ruth J. F. |
dc.contributor.author |
Pereira, Alexandre C. |
dc.contributor.author |
Province, Mike |
dc.contributor.author |
Psaty, Bruce M. |
dc.contributor.author |
Rotimi, Charles |
dc.contributor.author |
Zhu, Xiaofeng |
dc.contributor.author |
Amin, Najaf |
dc.contributor.author |
Cupples, L. Adrienne |
dc.contributor.author |
Fornage, Myriam |
dc.contributor.author |
Fox, Ervin F. |
dc.contributor.author |
Guo, Xiuqing |
dc.contributor.author |
Gauderman, W. James |
dc.contributor.author |
Rice, Kenneth |
dc.contributor.author |
Kooperberg, Charles |
dc.contributor.author |
Munroe, Patricia B. |
dc.contributor.author |
Liu, Ching-Ti |
dc.contributor.author |
Morrison, Alanna C. |
dc.contributor.author |
Rao, Dabeeru C. |
dc.contributor.author |
van Heemst, Diana |
dc.contributor.author |
Redline, Susan |
dc.date.accessioned |
2020-02-10T13:08:34Z |
dc.date.available |
2020-02-10T13:08:34Z |
dc.date.issued |
2019-11-12 |
dc.identifier.citation |
Noordam, R., Bos, M.M., Wang, H. et al. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat Commun 10, 5121 (2019). https://doi.org/10.1038/s41467-019-12958-0 |
dc.identifier.issn |
2041-1723 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/1522 |
dc.description |
Publisher's version (útgefin grein). |
dc.description.abstract |
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles. |
dc.description.sponsorship |
This project was supported by a grant from the US National Heart, Lung, and Blood
Institute (NHLBI) of the National Institutes of Health (R01HL118305). This research was
supported in part by the Intramural Research Program of the National Human Genome
Research Institute, National Institutes of Health. Tuomas O. Kilpeläinen was supported
by the Danish Council for Independent Research (DFF–6110-00183) and the Novo
Nordisk Foundation (NNF18CC0034900, NNF17OC0026848 and NNF15CC0018486).
Diana van Heemst was supported by the European Commission funded project
HUMAN (Health-2013-INNOVATION-1-602757). Susan Redline was supported in part
by NIH R35HL135818 and HL11338. Study-specific acknowledgements can be found in
the Supplementary Notes 2 and 4. The data on coronary artery disease have been contributed by the Myocardial Infarction Genetics and CARDIoGRAM investigators, and
have been downloaded from www.CARDIOGRAMPLUSC4D.ORG. |
dc.format.extent |
5121 |
dc.language.iso |
en |
dc.publisher |
Springer Science and Business Media LLC |
dc.relation.ispartofseries |
Nature Communications;10(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Dyslipidaemias |
dc.subject |
Epidemiology |
dc.subject |
Genome-wide association studies |
dc.subject |
Sleep |
dc.subject |
Svefn |
dc.subject |
Blóðfita |
dc.subject |
Svefnrannsóknir |
dc.subject |
Faraldsfræði |
dc.subject |
Erfðarannsóknir |
dc.title |
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
Open Access. This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/. |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Nature Communications |
dc.identifier.doi |
10.1038/s41467-019-12958-0 |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |