An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome—A SYSDIET Sub-Study
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MDPI AG
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A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and
reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet
(ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral
blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an
ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes
involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized
intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included
in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the
intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic
Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed.
The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A
(TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer
of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND
group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may
affect immune function.
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Publisher's version (útgefin grein).
Efnisorð
Metabolic syndrome, Randomized controlled dietary intervention, Gene expression, Peripheral blood mononuclear cells, Inflammation, Efnaskiptasjúkdómar, Bólgur, Mataræði, Genarannsóknir
Citation
Ulven, S.M. et al., 2019. An Isocaloric Nordic Diet Modulates and Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study. Nutrients, 11(12), pp.Nutrients, 03 December 2019, Vol.11(12).