An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome—A SYSDIET Sub-Study

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dc.contributorHáskóli Íslandsen_US
dc.contributorUniversity of Icelanden_US
dc.contributor.authorUlven, Stine M.
dc.contributor.authorHolven, Kirsten B.
dc.contributor.authorRundblad, Amanda
dc.contributor.authorMyhrstad, Mari C. W.
dc.contributor.authorLeder, Lena
dc.contributor.authorDahlman, Ingrid
dc.contributor.authorMello, Vanessa D. de
dc.contributor.authorSchwab, Ursula
dc.contributor.authorCarlberg, Carsten
dc.contributor.authorPihlajamäki, Jussi
dc.contributor.authorHermansen, Kjeld
dc.contributor.authorDragsted, Lars O.
dc.contributor.authorGunnarsdottir, Ingibjorg
dc.contributor.authorCloetens, Lieselotte
dc.contributor.authorÅkesson, Björn
dc.contributor.authorRosqvist, Fredrik
dc.contributor.authorHukkanen, Janne
dc.contributor.authorHerzig, Karl-Heinz
dc.contributor.authorSavolainen, Markku J
dc.contributor.authorRisérus, Ulf
dc.contributor.authorThorsdottir , Inga
dc.contributor.authorPoutanen, Kaisa S
dc.contributor.authorArner, Peter
dc.contributor.authorUusitupa, Matti
dc.contributor.authorKolehmainen, Marjukka
dc.contributor.departmentMatvæla- og næringarfræðideild (HÍ)en_US
dc.contributor.departmentFaculty of Food Science and Nutrition (UI)en_US
dc.contributor.schoolHeilbrigðisvísindasvið (HÍ)en_US
dc.contributor.schoolSchool of Health Sciences (UI)en_US
dc.date.accessioned2020-02-10T10:41:08Z
dc.date.available2020-02-10T10:41:08Z
dc.date.issued2019-12-03
dc.descriptionPublisher's version (útgefin grein).en_US
dc.description.abstractA healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.en_US
dc.description.sponsorshipFunding: This research was funded by the NordForsk Nordic Centre of Excellence in Food, Nutrition and Health project 070014 [SYSDIET (Systems Biology in Controlled Dietary Interventions and Cohort Studies)] and further, the University of Oslo (Norway), Throne Holst Foundation (Norway), Academy of Finland, Swedish Research council, Svenska Diabetesförbundet, SRP Diabetes, Finnish Diabetes Research Foundation, Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, EVO funding from Kuopio University Hospital (Finland), the Druvan Foundation, Skåne University Hospital, the Heart-Lung Foundation, Diabetesfonden and Foundation Cerealia (Sweden), the Agricultural Productivity Fund, and the Research Fund of the University of Iceland (Iceland). Acknowledgments: We thank Maritta Siloaho for their excellent expertise and advice for biochemical measurements and Marika Rönnholm for their excellent technical assistance.en_US
dc.description.versionPeer Revieweden_US
dc.format.extent2932en_US
dc.identifier.citationUlven, S.M. et al., 2019. An Isocaloric Nordic Diet Modulates and Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study. Nutrients, 11(12), pp.Nutrients, 03 December 2019, Vol.11(12).en_US
dc.identifier.doi10.3390/nu11122932
dc.identifier.issn2072-6643
dc.identifier.journalNutrientsen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11815/1516
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesNutrients;11(12)
dc.relation.urlhttps://www.mdpi.com/2072-6643/11/12/2932/pdfen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetabolic syndromeen_US
dc.subjectRandomized controlled dietary interventionen_US
dc.subjectGene expressionen_US
dc.subjectPeripheral blood mononuclear cellsen_US
dc.subjectInflammationen_US
dc.subjectEfnaskiptasjúkdómaren_US
dc.subjectBólguren_US
dc.subjectMataræðien_US
dc.subjectGenarannsókniren_US
dc.titleAn Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome—A SYSDIET Sub-Studyen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dcterms.licenseThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US

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