dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Plomp, Kimberly A. |
dc.contributor.author |
Dobney, Keith |
dc.contributor.author |
Weston, Darlene A. |
dc.contributor.author |
Viðarsdóttir, Una Strand |
dc.contributor.author |
Collard, Mark |
dc.date.accessioned |
2020-02-04T13:32:52Z |
dc.date.available |
2020-02-04T13:32:52Z |
dc.date.issued |
2019-12-16 |
dc.identifier.citation |
Plomp, K.A., Dobney, K., Weston, D.A. et al. 3D shape analyses of extant primate and fossil hominin vertebrae support the ancestral shape hypothesis for intervertebral disc herniation. BMC Evol Biol 19, 226 (2019). https://doi.org/10.1186/s12862-019-1550-9 |
dc.identifier.issn |
1471-2148 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/1504 |
dc.description |
Publisher's version (útgefin grein). |
dc.description.abstract |
Background: Recently we proposed an evolutionary explanation for a spinal pathology that afflicts many people, intervertebral disc herniation (Plomp et al. [2015] BMC Evolutionary Biology 15, 68). Using 2D data, we found that the bodies and pedicles of lower vertebrae of pathological humans were more similar in shape to those of chimpanzees than were those of healthy humans. Based on this, we hypothesized that some individuals are more prone to intervertebral disc herniation because their vertebrae exhibit ancestral traits and therefore are less well adapted for the stresses associated with bipedalism. Here, we report a study in which we tested this "Ancestral Shape Hypothesis" with 3D data from the last two thoracic and first lumbar vertebrae of pathological Homo sapiens, healthy H. sapiens, Pan troglodytes, and several extinct hominins. Results: We found that the pathological and healthy H. sapiens vertebrae differed significantly in shape, and that the pathological H. sapiens vertebrae were closer in shape to the P. troglodytes vertebrae than were the healthy H. sapiens vertebrae. Additionally, we found that the pathological human vertebrae were generally more similar in shape to the vertebrae of the extinct hominins than were the healthy H. sapiens vertebrae. These results are consistent with the predictions of the Ancestral Shape Hypothesis. Several vertebral traits were associated with disc herniation, including a vertebral body that is both more circular and more ventrally wedged, relatively short pedicles and laminae, relatively long, more cranio-laterally projecting transverse processes, and relatively long, cranially-oriented spinous processes. We found that there are biomechanical and comparative anatomical reasons for suspecting that all of these traits are capable of predisposing individuals to intervertebral disc herniation. Conclusions: The results of the present study add weight to the hypothesis that intervertebral disc herniation in H. sapiens is connected with vertebral shape. Specifically, they suggest that individuals whose vertebrae are towards the ancestral end of the range of shape variation within H. sapiens have a greater propensity to develop the condition than other individuals. More generally, the study shows that evolutionary thinking has the potential to shed new light on human skeletal pathologies. |
dc.description.sponsorship |
We thank the following institutions for access to the specimens used in this
study: Naturhistorisches Museum, Vienna, Austria; Museum für Naturkunde,
Berlin, Germany; University of Zürich’s Anthropological Institute & Museum,
Zürich, Switzerland; the University of Copenhagen’s Department of Forensic
Medicine, Copenhagen, Denmark; the Smithsonian Institute Museum of
Natural History, Washington, DC, USA; and the Cleveland Museum of Natural
History, Cleveland, Ohio, USA. We also thank Allowen Evin for her assistance
with the analyses. This study was supported by the Social Sciences and
Humanities Research Council of Canada (895-2011-1009), Canada Research
Chairs Program (228117 and 231256), Canada Foundation for Innovation
(203808 and 36801), British Columbia Knowledge Development Fund
(862-804231 and 962-805808), Simon Fraser University (14518), MITACS
(IT03519), the Wenner-Gren Foundation (62447), and Marie Skłodowska-Curie
Actions (SAR10359). |
dc.format.extent |
226 |
dc.language.iso |
en |
dc.publisher |
Springer Science and Business Media LLC |
dc.relation.ispartofseries |
BMC Evolutionary Biology;19(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Back pain |
dc.subject |
Bipedalism |
dc.subject |
Human evolution |
dc.subject |
Intervertebral disc herniation |
dc.subject |
Spine |
dc.subject |
Vertebrae |
dc.subject |
Bakveiki |
dc.subject |
Þróun mannsins |
dc.subject |
Hryggurinn |
dc.subject |
Mænan |
dc.title |
3D shape analyses of extant primate and fossil hominin vertebrae support the ancestral shape hypothesis for intervertebral disc herniation |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
BMC Evolutionary Biology |
dc.identifier.doi |
10.1186/s12862-019-1550-9 |
dc.contributor.department |
Lífvísindasetur (HÍ) |
dc.contributor.department |
Biomedical Center (UI) |
dc.contributor.school |
School of Health Sciences (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |