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Plasma Concentrations of Long Chain N-3 Fatty Acids in Early and Mid-Pregnancy and Risk of Early Preterm Birth

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dc.contributor Háskóli Íslands (HÍ)
dc.contributor University of Iceland (UI)
dc.contributor.author Olsen, S.F.
dc.contributor.author Halldorsson, Thorhallur
dc.contributor.author Thorne-Lyman, A.L.
dc.contributor.author Strøm, M.
dc.contributor.author Gørtz, S.
dc.contributor.author Granstrøm, C.
dc.contributor.author Nielsen, P.H.
dc.contributor.author Wohlfahrt, J.
dc.contributor.author Lykke, J.A.
dc.contributor.author Langhoff-Roos, J.
dc.contributor.author Cohen, A.S.
dc.contributor.author Furtado, J.D.
dc.contributor.author Giovannucci, E.L.
dc.contributor.author Zhou, W.
dc.date.accessioned 2020-01-14T10:19:20Z
dc.date.available 2020-01-14T10:19:20Z
dc.date.issued 2018-09
dc.identifier.citation Olsen, S. et al., 2018. Plasma Concentrations of Long Chain N-3 Fatty Acids in Early and Mid-Pregnancy and Risk of Early Preterm Birth. EBioMedicine, 35, pp.325–333.
dc.identifier.issn 2352-3964
dc.identifier.uri https://hdl.handle.net/20.500.11815/1454
dc.description Publisher's version (útgefin grein).
dc.description.abstract Background: Fish oil supplementation has been shown to delay spontaneous delivery, but the levels and clinical significance remain uncertain. We examined the association between plasma fatty acids quantified in pregnancy and subsequent risk of early preterm birth. Methods: In a case-control design nested in the Danish National Birth Cohort, we identified 376 early preterm cases (<34 gestational weeks, excluding preeclampsia cases) and 348 random controls. Plasma eicosapentaenoic acid plus docosahexaenoic acid (EPA+DHA% of total fatty acids), were measured twice in pregnancy, at gestation weeks 9 and 25 (medians). Odds ratios and 95% confidence intervals (CI's) for associations between EPA+DHA and early preterm risk were estimated by logistic regression, adjusted for the woman's age, height, pre-pregnancy BMI, parity, smoking, and socioeconomic factors. Hypotheses and analytical plan were defined and archived a priori. Findings: Analysis using restricted cubic splines of the mean of 1st and 2nd sample measurements showed a strong and significant non-linear association (p < 0.0001) in which the risk of early preterm birth steeply increased when EPA+DHA concentrations were lower than 2% and flattened out at higher levels. Women in the lowest quintile (EPA+DHA < 1.6%) had 10.27 times (95% confidence interval 6.80–15.79, p < 0.0001) increased risk, and women in the second lowest quintile had 2.86 (95% CI 1.79–4.59, p < 0.0001) times increased risk, when compared to women in the three aggregated highest quintiles (EPA+DHA ≥ 1.8%). Interpretation: Low plasma concentration of EPA and DHA during pregnancy is a strong risk factor for subsequent early preterm birth in Danish women.
dc.description.sponsorship Financial support was received from March of Dimes Birth Defects Foundation ( 6-FY-96-0240 , 6-FY97-0553 , 6-FY97-0521 , 6-FY00-407 ), Innovation Fund Denmark (grant no. 09-067124 , ‘Centre for Fetal Programming’), Danish Council for Independent Research (grant no. 1331-00229A , 9601842 and 22-03-0536 ), the Health Foundation ( 11/263-96 ), and the Heart Foundation ( 96-2-4-83-22450 ), Danish National Research Foundation. This research has been conducted using the Danish National Biobank resource, supported by the Novo Nordisk Foundation , grant number 2010-11-12 and 2009-07-28 . The funding agencies did not have any role in design and conduct of the study; collection, management, and interpretation of the data; or preparation, review, or approval of the manuscript.
dc.format.extent 325-333
dc.language.iso en
dc.publisher Elsevier BV
dc.relation.ispartofseries EBioMedicine;35
dc.rights info:eu-repo/semantics/openAccess
dc.subject Biomarkers
dc.subject Danish National Birth Cohort
dc.subject Early preterm birth
dc.subject Long chained n-3 fatty acids
dc.subject Prospective study
dc.subject Meðganga
dc.subject Fyrirburar
dc.subject Ómega-3 fitusýrur
dc.title Plasma Concentrations of Long Chain N-3 Fatty Acids in Early and Mid-Pregnancy and Risk of Early Preterm Birth
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.description.version Peer Reviewed
dc.identifier.journal EBioMedicine
dc.identifier.doi 10.1016/j.ebiom.2018.07.009
dc.contributor.department Faculty of Food Science and Nutrition (UI)
dc.contributor.department Matvæla- og næringarfræðideild (HÍ)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)


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