Opin vísindi

Evaluation of intranasal delivery route of drug administration for brain targeting

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dc.contributor Háskóli Íslands (HÍ)
dc.contributor University of Iceland (UI)
dc.contributor.author Erdő, Franciska
dc.contributor.author Bors, Luca Anna
dc.contributor.author Farkas, Dániel
dc.contributor.author Bajza, Ágnes
dc.contributor.author Gizurarson, Sveinbjorn
dc.date.accessioned 2019-12-16T16:02:20Z
dc.date.available 2019-12-16T16:02:20Z
dc.date.issued 2018-10
dc.identifier.citation Erdő, F., Bors, L. A., Farkas, D., Bajza, Á., & Gizurarson, S. (2018). Evaluation of intranasal delivery route of drug administration for brain targeting. Brain Research Bulletin, 143, 155-170. doi:https://doi.org/10.1016/j.brainresbull.2018.10.009
dc.identifier.issn 0361-9230
dc.identifier.uri https://hdl.handle.net/20.500.11815/1402
dc.description Publisher's version (útgefin grein)
dc.description.abstract The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challengingfrom several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism,elimination, the unwanted side effects and also the high dose to be added mean both inconvenience for thepatients and high costs for the patients, their family and the society. The reason of low brain penetration of thecompounds is that they have to overcome the blood-brain barrier which protects the brain against xenobiotics.Intranasal drug administration is one of the promising options to bypass blood-brain barrier, to reduce thesystemic adverse effects of the drugs and to lower the doses to be administered. Furthermore, the drugs ad-ministered using nasal route have usually higher bioavailability, less side effects and result in higher brainexposure at similar dosage than the oral drugs. In this review the focus is on giving an overview on the ana-tomical and cellular structure of nasal cavity and absorption surface. It presents some possibilities to enhance thedrug penetration through the nasal barrier and summarizes somein vitro,ex vivoandin vivotechnologies to testthe drug delivery across the nasal epithelium into the brain. Finally, the authors give a critical evaluation of thenasal route of administration showing its main advantages and limitations of this delivery route for CNS drugtargeting
dc.description.sponsorship The authors thank the Faculty of Information Technology andBionics, Pázmány Péter Catholic University, Budapest, for the supportof the publication costs of this article. This work was partly supportedby the European Union through grant no. EFOP-3.6.3-VEKOP-16-2017-00002 co-financed by the European Social Fund and also by theNational Bionics Program of Hungary.
dc.format.extent 155-170
dc.language.iso en
dc.publisher Elsevier BV
dc.relation.ispartofseries Brain Research Bulletin;143
dc.rights info:eu-repo/semantics/openAccess
dc.subject Intranasal administration
dc.subject Drug delivery
dc.subject CNS indication
dc.subject Delivery enhancer techniques
dc.subject Transporter interactions
dc.subject Lyfjameðferð
dc.subject Taugasjúkdómar
dc.subject Geðsjúkdómar
dc.subject Nefkok
dc.subject Lyfjagjöf
dc.title Evaluation of intranasal delivery route of drug administration for brain targeting
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).T
dc.description.version Peer Reviewed
dc.identifier.journal Brain Research Bulletin
dc.identifier.doi 10.1016/j.brainresbull.2018.10.009
dc.contributor.department Lyfjafræðideild (HÍ)
dc.contributor.department Faculty of Pharmaceutical Sciences (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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