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2-Hydroxypropyl-β-Cyclodextrin Aggregates: Identification and Development of Analytical Techniques

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dc.contributor Háskóli Íslands (HÍ)
dc.contributor University of Iceland (UI)
dc.contributor.author Sá Couto, André
dc.contributor.author Ryzhakov, Alexey
dc.contributor.author Loftsson, Thorsteinn
dc.date.accessioned 2019-12-16T15:50:58Z
dc.date.available 2019-12-16T15:50:58Z
dc.date.issued 2018-10-13
dc.identifier.citation Sá Couto, A.R.; Ryzhakov, A.; Loftsson, T. 2-Hydroxypropyl-β-Cyclodextrin Aggregates: Identification and Development of Analytical Techniques. Materials 2018, 11, 1971. doi:10.3390/ma11101971
dc.identifier.issn 1996-1944
dc.identifier.uri https://hdl.handle.net/20.500.11815/1401
dc.description Publisher's version (útgefin grein)
dc.description.abstract It is extremely important for pharmaceutical formulators to have analytical methodology that provides efficient detection and quantification of HPβCD aggregates. Five different methods were then evaluated for their potential to detect these aggregates and to determine critical aggregation concentration (cac): osmometry, viscometry, tensiometry, dynamic light scattering (DLS), and permeability studies. Overall, tensiometry was an inadequate method with which to study HPβCD aggregation, since the addition of HPβCD to water resulted in only minor changes in surface tension. Osmolality and viscosity studies have shown that for HPβCD, solute–solvent interactions are the main contributors for the observed deviation from ideality. These deviations might be related to the presence of aggregates. The DLS method proved to be an effective method with which to detect HPβCD aggregates and estimate their hydrodynamic diameter, although it presented some limitations concerning their quantification. In terms of the assessed methods, permeation studies were shown to be the best to study HPβCD aggregation phenomena, since they were the only method where the detection of aggregates and the determination of apparent cac values was possible. Also, it was the least invasive for the HPβCD samples and the method that provided more conclusive data. Results suggested that HPβCD, as expected, has less tendency to form aggregates than βCD
dc.description.sponsorship Funding: This research was funded by the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT), grant number 135040. Acknowledgments: The financial support received from the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT) (Grant No. 135040) is gratefully acknowledged.
dc.format.extent 1971
dc.language.iso en
dc.publisher MDPI AG
dc.relation.ispartofseries Materials;11(10)
dc.rights info:eu-repo/semantics/openAccess
dc.subject 2-hydroxypropyl-β-cyclodextrin
dc.subject Aggregation
dc.subject Critical aggregation concentration
dc.subject Permeation
dc.subject Nanoparticles
dc.subject Lyfjafræði
dc.subject Efnasambönd
dc.title 2-Hydroxypropyl-β-Cyclodextrin Aggregates: Identification and Development of Analytical Techniques
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.description.version Peer Reviewed
dc.identifier.journal Materials
dc.identifier.doi 10.3390/ma11101971
dc.relation.url http://www.mdpi.com/1996-1944/11/10/1971/pdf
dc.contributor.department Faculty of Pharmaceutical Sciences (UI)
dc.contributor.department Lyfjafræðideild (HÍ)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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