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The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants

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dc.contributor Háskóli Íslands (HÍ)
dc.contributor University of Iceland (UI)
dc.contributor.author Marzetti, Emanuele
dc.contributor.author Cesari, Matteo
dc.contributor.author Calvani, Riccardo
dc.contributor.author Msihid, Jérôme
dc.contributor.author Tosato, Matteo
dc.contributor.author Rodriguez-Mañas, Leocadio
dc.contributor.author Lattanzio, Fabrizia
dc.contributor.author Cherubini, Antonio
dc.contributor.author Bejuit, Raphaël
dc.contributor.author Di Bari, Mauro
dc.contributor.author Maggio, Marcello
dc.contributor.author Vellas, Bruno
dc.contributor.author Dantoine, Thierry
dc.contributor.author Cruz-Jentoft, Alfonso J.
dc.contributor.author Sieber, Cornel C.
dc.contributor.author Freiberger, Ellen
dc.contributor.author Skalska, Anna
dc.contributor.author Grodzicki, Tomasz
dc.contributor.author Sinclair, Alan J.
dc.contributor.author Topinkova, Eva
dc.contributor.author Rýznarová, Ingrid
dc.contributor.author Strandberg, Timo
dc.contributor.author Schols, Annemie M.W.J.
dc.contributor.author Schols, Jos M.G.A.
dc.contributor.author Roller-Wirnsberger, Regina
dc.contributor.author Jónsson, Pálmi V.
dc.contributor.author Ramel, Alfons
dc.contributor.author Del Signore, Susanna
dc.contributor.author Pahor, Marco
dc.contributor.author Roubenoff, Ronenn
dc.contributor.author Bernabei, Roberto
dc.contributor.author Landi, Francesco
dc.date.accessioned 2019-12-16T14:54:46Z
dc.date.available 2019-12-16T14:54:46Z
dc.date.issued 2018-11
dc.identifier.citation Marzetti, E., Cesari, M., Calvani, R., Msihid, J., Tosato, M., Rodriguez-Mañas, L., . . . Landi, F. (2018). The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants. Experimental Gerontology, 113, 48-57. doi:https://doi.org/10.1016/j.exger.2018.09.017
dc.identifier.issn 0531-5565
dc.identifier.uri https://hdl.handle.net/20.500.11815/1399
dc.description Publisher's version (útgefin grein)
dc.description.abstract Background:The ongoing “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment stra-tegies (SPRINTT)” randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention inthe prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describethe procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. Wealso illustrate the main demographic and clinical characteristics of eligible screenees.Methods:The identification of PF&S was based on the co-occurrence of three defining elements: (1) reducedphysical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) lowmuscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3)absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT wasadvertised through a variety of means. Site-specific case finding strategies were developed to accommodate thevariability across centers in catchment area characteristics and access to the target population. A quick “parti-cipant profiling” questionnaire was devised to facilitate PF&S case finding.Results:During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sitesresulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participatingin the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidityburden. In most centers, project advertisement through mass media was the most rewarding case findingstrategy.Conclusion:PF&S case finding in the community is a challenging, but feasible task. Although largely autonomousin daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity.This subset of the older population is therefore at high risk for disability and other negative health-relatedevents. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass com-munication methods.
dc.description.sponsorship The present work was funded by a grant from the InnovativeMedicines Initiative - Joint Undertaking (IMI-JU 115621). The workwas also partly supported by the nonprofit research foundation “CentroStudi Achille e Linda Lorenzon” and by intramural research grants fromthe Università Cattolica del Sacro Cuore (D3.2 2013 and D3.2 2015).The authors thank all the participants and the staff involved in thetrial for the enthusiastic participation and dedication.
dc.format.extent 48-57
dc.language.iso en
dc.publisher Elsevier BV
dc.relation.ispartofseries Experimental Gerontology;113
dc.rights info:eu-repo/semantics/openAccess
dc.subject Physical performance
dc.subject Mobility disability
dc.subject Functional impairment
dc.subject Recruitment
dc.subject Prevention
dc.subject Skeletal muscle
dc.subject Hreyfifærni
dc.subject Hreyfihömlun
dc.subject Beinin
dc.title The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).T
dc.description.version Peer Reviewed
dc.identifier.journal Experimental Gerontology
dc.identifier.doi 10.1016/j.exger.2018.09.017
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.department Læknadeild (HÍ)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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