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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

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dc.contributor Háskóli Íslands (HÍ)
dc.contributor University of Iceland (UI)
dc.contributor.author Davies, Gail
dc.contributor.author Lam, Max
dc.contributor.author Harris, Sarah E.
dc.contributor.author Trampush, Joey W.
dc.contributor.author Luciano, Michelle
dc.contributor.author Hill, W. David
dc.contributor.author Hagenaars, Saskia P.
dc.contributor.author Ritchie, Stuart J.
dc.contributor.author Marioni, Riccardo E.
dc.contributor.author Fawns-Ritchie, Chloe
dc.contributor.author Liewald, David C. M.
dc.contributor.author Okely, Judith A.
dc.contributor.author Ahola-Olli, Ari V.
dc.contributor.author Barnes, Catriona L. K.
dc.contributor.author Bertram, Lars
dc.contributor.author Bis, Joshua C.
dc.contributor.author Burdick, Katherine E.
dc.contributor.author Christoforou, Andrea
dc.contributor.author DeRosse, Pamela
dc.contributor.author Djurovic, Srdjan
dc.contributor.author Espeseth, Thomas
dc.contributor.author Giakoumaki, Stella
dc.contributor.author Giddaluru, Sudheer
dc.contributor.author Gustavson, Daniel E.
dc.contributor.author Hayward, Caroline
dc.contributor.author Hofer, Edith
dc.contributor.author Ikram, M. Arfan
dc.contributor.author Karlsson, Robert
dc.contributor.author Knowles, Emma
dc.contributor.author Lahti, Jari
dc.contributor.author Leber, Markus
dc.contributor.author Li, Shuo
dc.contributor.author Mather, Karen A.
dc.contributor.author Melle, Ingrid
dc.contributor.author Morris, Derek
dc.contributor.author Oldmeadow, Christopher
dc.contributor.author Palviainen, Teemu
dc.contributor.author Payton, Antony
dc.contributor.author Pazoki, Raha
dc.contributor.author Petrovic, Katja
dc.contributor.author Reynolds, Chandra A.
dc.contributor.author Sargurupremraj, Muralidharan
dc.contributor.author Scholz, Markus
dc.contributor.author Smith, Jennifer A.
dc.contributor.author Smith, Albert Vernon
dc.contributor.author Terzikhan, Natalie
dc.contributor.author Thalamuthu, Anbupalam
dc.contributor.author Trompet, Stella
dc.contributor.author van der Lee, Sven J.
dc.contributor.author Ware, Erin B.
dc.contributor.author Windham, B. Gwen
dc.contributor.author Wright, Margaret J.
dc.contributor.author Yang, Jingyun
dc.contributor.author Yu, Jin
dc.contributor.author Ames, David
dc.contributor.author Amin, Najaf
dc.contributor.author Amouyel, Philippe
dc.contributor.author Andreassen, Ole A.
dc.contributor.author Armstrong, Nicola J.
dc.contributor.author Assareh, Amelia A.
dc.contributor.author Attia, John R.
dc.contributor.author Attix, Deborah
dc.contributor.author Avramopoulos, Dimitrios
dc.contributor.author Bennett, David A.
dc.contributor.author Böhmer, Anne C.
dc.contributor.author Boyle, Patricia A.
dc.contributor.author Brodaty, Henry
dc.contributor.author Campbell, Harry
dc.contributor.author Cannon, Tyrone D.
dc.contributor.author Cirulli, Elizabeth T.
dc.contributor.author Congdon, Eliza
dc.contributor.author Conley, Emily Drabant
dc.contributor.author Corley, Janie
dc.contributor.author Cox, Simon R.
dc.contributor.author Dale, Anders M.
dc.contributor.author Dehghan, Abbas
dc.contributor.author Dick, Danielle
dc.contributor.author Dickinson, Dwight
dc.contributor.author Eriksson, Johan G.
dc.contributor.author Evangelou, Evangelos
dc.contributor.author Faul, Jessica D.
dc.contributor.author Ford, Ian
dc.contributor.author Freimer, Nelson A.
dc.contributor.author Gao, He
dc.contributor.author Giegling, Ina
dc.contributor.author Gillespie, Nathan A.
dc.contributor.author Gordon, Scott D.
dc.contributor.author Gottesman, Rebecca F.
dc.contributor.author Griswold, Michael E.
dc.contributor.author Gudnason, Vilmundur
dc.contributor.author Harris, Tamara B.
dc.contributor.author Hartmann, Annette M.
dc.contributor.author Hatzimanolis, Alex
dc.contributor.author Heiss, Gerardo
dc.contributor.author Holliday, Elizabeth G.
dc.contributor.author Joshi, Peter K.
dc.contributor.author Kähönen, Mika
dc.contributor.author Kardia, Sharon L. R.
dc.contributor.author Karlsson, Ida
dc.contributor.author Kleineidam, Luca
dc.contributor.author Knopman, David S.
dc.contributor.author Kochan, Nicole A.
dc.contributor.author Konte, Bettina
dc.contributor.author Kwok, John B.
dc.contributor.author Le Hellard, Stephanie
dc.contributor.author Lee, Teresa
dc.contributor.author Lehtimäki, Terho
dc.contributor.author Li, Shu-Chen
dc.contributor.author Lill, Christina M.
dc.contributor.author Liu, Tian
dc.contributor.author Koini, Marisa
dc.contributor.author London, Edythe
dc.contributor.author Longstreth, Will T.
dc.contributor.author Lopez, Oscar L.
dc.contributor.author Loukola, Anu
dc.contributor.author Luck, Tobias
dc.contributor.author Lundervold, Astri J.
dc.contributor.author Lundquist, Anders
dc.contributor.author Lyytikäinen, Leo-Pekka
dc.contributor.author Martin, Nicholas G.
dc.contributor.author Montgomery, Grant W.
dc.contributor.author Murray, Alison D.
dc.contributor.author Need, Anna C.
dc.contributor.author Noordam, Raymond
dc.contributor.author Nyberg, Lars
dc.contributor.author Ollier, William
dc.contributor.author Papenberg, Goran
dc.contributor.author Pattie, Alison
dc.contributor.author Polasek, Ozren
dc.contributor.author Poldrack, Russell A.
dc.contributor.author Psaty, Bruce M.
dc.contributor.author Reppermund, Simone
dc.contributor.author Riedel-Heller, Steffi G.
dc.contributor.author Rose, Richard J.
dc.contributor.author Rotter, Jerome I.
dc.contributor.author Roussos, Panos
dc.contributor.author Rovio, Suvi P.
dc.contributor.author Saba, Yasaman
dc.contributor.author Sabb, Fred W.
dc.contributor.author Sachdev, Perminder S.
dc.contributor.author Satizabal, Claudia L.
dc.contributor.author Schmid, Matthias
dc.contributor.author Scott, Rodney J.
dc.contributor.author Scult, Matthew A.
dc.contributor.author Simino, Jeannette
dc.contributor.author Slagboom, P. Eline
dc.contributor.author Smyrnis, Nikolaos
dc.contributor.author Soumaré, Aïcha
dc.contributor.author Stefanis, Nikos C.
dc.contributor.author Stott, David J.
dc.contributor.author Straub, Richard E.
dc.contributor.author Sundet, Kjetil
dc.contributor.author Taylor, Adele M.
dc.contributor.author Taylor, Kent D.
dc.contributor.author Tzoulaki, Ioanna
dc.contributor.author Tzourio, Christophe
dc.contributor.author Uitterlinden, André
dc.contributor.author Vitart, Veronique
dc.contributor.author Voineskos, Aristotle N.
dc.contributor.author Kaprio, Jaakko
dc.contributor.author Wagner, Michael
dc.contributor.author Wagner, Holger
dc.contributor.author Weinhold, Leonie
dc.contributor.author Wen, K. Hoyan
dc.contributor.author Widen, Elisabeth
dc.contributor.author Yang, Qiong
dc.contributor.author Zhao, Wei
dc.contributor.author Adams, Hieab H. H.
dc.contributor.author Arking, Dan E.
dc.contributor.author Bilder, Robert M.
dc.contributor.author Bitsios, Panos
dc.contributor.author Boerwinkle, Eric
dc.contributor.author Chiba-Falek, Ornit
dc.contributor.author Corvin, Aiden
dc.contributor.author De Jager, Philip L.
dc.contributor.author Debette, Stéphanie
dc.contributor.author Donohoe, Gary
dc.contributor.author Elliott, Paul
dc.contributor.author Fitzpatrick, Annette L.
dc.contributor.author Gill, Michael
dc.contributor.author Glahn, David C.
dc.contributor.author Hägg, Sara
dc.contributor.author Hansell, Narelle K.
dc.contributor.author Hariri, Ahmad R.
dc.contributor.author Ikram, M. Kamran
dc.contributor.author Jukema, J. Wouter
dc.contributor.author Vuoksimaa, Eero
dc.contributor.author Keller, Matthew C.
dc.contributor.author Kremen, William S.
dc.contributor.author Launer, Lenore
dc.contributor.author Lindenberger, Ulman
dc.contributor.author Palotie, Aarno
dc.contributor.author Pedersen, Nancy L.
dc.contributor.author Pendleton, Neil
dc.contributor.author Porteous, David J.
dc.contributor.author Räikkönen, Katri
dc.contributor.author Raitakari, Olli T.
dc.contributor.author Ramirez, Alfredo
dc.contributor.author Reinvang, Ivar
dc.contributor.author Rudan, Igor
dc.date.accessioned 2019-12-16T13:07:56Z
dc.date.available 2019-12-16T13:07:56Z
dc.date.issued 2018-05-29
dc.identifier.citation Davies, G., Lam, M., Harris, S.E. et al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun 9, 2098 (2018) doi:10.1038/s41467-018-04362-x
dc.identifier.issn 2041-1723
dc.identifier.uri https://hdl.handle.net/20.500.11815/1394
dc.description Publisher's version (útgefin grein)
dc.description.abstract General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
dc.description.sponsorship This research was conducted in The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council (MR/K026992/1). This research was conducted using the UK Biobank Resource (Application Nos. 10279 and 4844). The Neurology Working Group within the Cohorts for Heart and Aging Research in Genomic Epidemiology is partly supported by grants from the National Institute on Aging (R01 AG033193, U01 AG049505 and U01 AG052409). Cohort-specific acknowledgements are in Supplementary Note 3.
dc.format.extent 2098
dc.language.iso en
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartofseries Nature Communications;9(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Cognitive neuroscience
dc.subject Genetics of the nervous system
dc.subject Genome-wide association studies
dc.subject Quantitative trait
dc.subject Taugavísindi
dc.subject Erfðafræði
dc.subject Rannsóknir
dc.subject Heilinn
dc.title Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
dc.type info:eu-repo/semantics/article
dcterms.license Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.description.version Peer Reviewed
dc.identifier.journal Nature Communications
dc.identifier.doi 10.1038/s41467-018-04362-x
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)


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