Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

Vojinovic, Dina; Adams, Hieab H.; Jian, Xueqiu; Yang, Qiong; Smith, Albert Vernon; Bis, Joshua C.; Teumer, Alexander; Scholz, Markus; Armstrong, Nicola J.; Hofer, Edith; Saba, Yasaman; Luciano, Michelle; Bernard, Manon; Trompet, Stella; Yang, Jingyun; Gillespie, Nathan A.; van der Lee, Sven J.; Neumann, Alexander; Ahmad, Shahzad; Andreassen, Ole A.; Ames, David; Amin, Najaf; Arfanakis, Konstantinos; Bastin, Mark E.; Becker, Diane M.; Beiser, Alexa S.; Beyer, Frauke; Brodaty, Henry; Bryan, R. Nick; Bülow, Robin; Dale, Anders M.; De Jager, Philip L.; Deary, Ian J.; DeCarli, Charles; Fleischman, Debra A.; Gottesman, Rebecca F.; van der Grond, Jeroen; Gudnason, Vilmundur; Harris, Tamara B.; Homuth, Georg; Knopman, David S.; Kwok, John B.; Lewis, Cora E.; Li, Shuo; Loeffler, Markus; Lopez, Oscar L.; Maillard, Pauline; El Marroun, Hanan; Mather, Karen A.; Mosley, Thomas H.; Muetzel, Ryan L.; Nauck, Matthias; Nyquist, Paul A.; Panizzon, Matthew S.; Pausova, Zdenka; Psaty, Bruce M.; Rice, Ken; Rotter, Jerome I.; Royle, Natalie; Satizabal, Claudia L.; Schmidt, Reinhold; Schofield, Peter R.; Schreiner, Pamela J.; Sidney, Stephen; Stott, David J.; Thalamuthu, Anbupalam; Uitterlinden, Andre G.; Valdés Hernández, Maria C.; Vernooij, Meike W.; Wen, Wei; White, Tonya; Witte, A. Veronica; Wittfeld, Katharina; Wright, Margaret J.; Yanek, Lisa R.; Tiemeier, Henning; Kremen, William S.; Bennett, David A.; Jukema, J. Wouter; Paus, Tomas; Wardlaw, Joanna M.; Schmidt, Helena; Sachdev, Perminder S.; Villringer, Arno; Grabe, Hans Jörgen; Longstreth, W T; van Duijn, Cornelia M.; Launer, Lenore J.; Seshadri, Sudha; Ikram, M Arfan; Fornage, Myriam

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dc.contributor	Háskóli Íslands (HÍ)
dc.contributor	University of Iceland (UI)
dc.contributor.author	Vojinovic, Dina
dc.contributor.author	Adams, Hieab H.
dc.contributor.author	Jian, Xueqiu
dc.contributor.author	Yang, Qiong
dc.contributor.author	orcid.org/0000-0003-1942-5845 Smith, Albert Vernon
dc.contributor.author	Bis, Joshua C.
dc.contributor.author	Teumer, Alexander
dc.contributor.author	Scholz, Markus
dc.contributor.author	Armstrong, Nicola J.
dc.contributor.author	Hofer, Edith
dc.contributor.author	Saba, Yasaman
dc.contributor.author	Luciano, Michelle
dc.contributor.author	Bernard, Manon
dc.contributor.author	Trompet, Stella
dc.contributor.author	Yang, Jingyun
dc.contributor.author	Gillespie, Nathan A.
dc.contributor.author	van der Lee, Sven J.
dc.contributor.author	Neumann, Alexander
dc.contributor.author	Ahmad, Shahzad
dc.contributor.author	Andreassen, Ole A.
dc.contributor.author	Ames, David
dc.contributor.author	Amin, Najaf
dc.contributor.author	Arfanakis, Konstantinos
dc.contributor.author	Bastin, Mark E.
dc.contributor.author	Becker, Diane M.
dc.contributor.author	Beiser, Alexa S.
dc.contributor.author	Beyer, Frauke
dc.contributor.author	Brodaty, Henry
dc.contributor.author	Bryan, R. Nick
dc.contributor.author	Bülow, Robin
dc.contributor.author	Dale, Anders M.
dc.contributor.author	De Jager, Philip L.
dc.contributor.author	Deary, Ian J.
dc.contributor.author	DeCarli, Charles
dc.contributor.author	Fleischman, Debra A.
dc.contributor.author	Gottesman, Rebecca F.
dc.contributor.author	van der Grond, Jeroen
dc.contributor.author	orcid.org/0000-0001-5696-0084 Gudnason, Vilmundur
dc.contributor.author	Harris, Tamara B.
dc.contributor.author	Homuth, Georg
dc.contributor.author	Knopman, David S.
dc.contributor.author	Kwok, John B.
dc.contributor.author	Lewis, Cora E.
dc.contributor.author	Li, Shuo
dc.contributor.author	Loeffler, Markus
dc.contributor.author	Lopez, Oscar L.
dc.contributor.author	Maillard, Pauline
dc.contributor.author	El Marroun, Hanan
dc.contributor.author	Mather, Karen A.
dc.contributor.author	Mosley, Thomas H.
dc.contributor.author	Muetzel, Ryan L.
dc.contributor.author	Nauck, Matthias
dc.contributor.author	Nyquist, Paul A.
dc.contributor.author	Panizzon, Matthew S.
dc.contributor.author	Pausova, Zdenka
dc.contributor.author	Psaty, Bruce M.
dc.contributor.author	Rice, Ken
dc.contributor.author	Rotter, Jerome I.
dc.contributor.author	Royle, Natalie
dc.contributor.author	Satizabal, Claudia L.
dc.contributor.author	Schmidt, Reinhold
dc.contributor.author	Schofield, Peter R.
dc.contributor.author	Schreiner, Pamela J.
dc.contributor.author	Sidney, Stephen
dc.contributor.author	Stott, David J.
dc.contributor.author	Thalamuthu, Anbupalam
dc.contributor.author	Uitterlinden, Andre G.
dc.contributor.author	Valdés Hernández, Maria C.
dc.contributor.author	Vernooij, Meike W.
dc.contributor.author	Wen, Wei
dc.contributor.author	White, Tonya
dc.contributor.author	Witte, A. Veronica
dc.contributor.author	Wittfeld, Katharina
dc.contributor.author	Wright, Margaret J.
dc.contributor.author	Yanek, Lisa R.
dc.contributor.author	Tiemeier, Henning
dc.contributor.author	Kremen, William S.
dc.contributor.author	Bennett, David A.
dc.contributor.author	Jukema, J. Wouter
dc.contributor.author	Paus, Tomas
dc.contributor.author	Wardlaw, Joanna M.
dc.contributor.author	Schmidt, Helena
dc.contributor.author	Sachdev, Perminder S.
dc.contributor.author	Villringer, Arno
dc.contributor.author	Grabe, Hans Jörgen
dc.contributor.author	Longstreth, W T
dc.contributor.author	van Duijn, Cornelia M.
dc.contributor.author	Launer, Lenore J.
dc.contributor.author	Seshadri, Sudha
dc.contributor.author	Ikram, M Arfan
dc.contributor.author	Fornage, Myriam
dc.date.accessioned	2019-12-16T11:25:22Z
dc.date.available	2019-12-16T11:25:22Z
dc.date.issued	2018-09-26
dc.identifier.citation	Vojinovic, D., Adams, H.H., Jian, X. et al. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nat Commun 9, 3945 (2018) doi:10.1038/s41467-018-06234-w
dc.identifier.issn	2041-1723
dc.identifier.uri	https://hdl.handle.net/20.500.11815/1391
dc.description	Publisher's version (útgefin grein) Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
dc.description.abstract	The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρgenetic = −0.59, p-value = 3.14 × 10−6), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology.
dc.description.sponsorship	See Supplementary Note 2 for information on funding sources.
dc.format.extent	3945
dc.language.iso	en
dc.publisher	Springer Science and Business Media LLC
dc.relation	info:eu-repo/grantAgreement/EC/FP7/201413
dc.relation.ispartofseries	Nature Communications;9(1)
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Brain
dc.subject	Enlargement
dc.subject	Genomes
dc.subject	Elderly people
dc.subject	Ventricle (lateral)
dc.subject	Mental disorders
dc.subject	Genetics of the nervous system
dc.subject	Genome-wide association studies
dc.subject	Heritable quantitative trait
dc.subject	Erfðafræði
dc.subject	Rannsóknir
dc.subject	Heilinn
dc.subject	Litningarannsóknir
dc.title	Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume
dc.type	info:eu-repo/semantics/article
dcterms.license	Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.description.version	Peer Reviewed
dc.identifier.journal	Nature Communications
dc.identifier.doi	10.1038/s41467-018-06234-w
dc.contributor.department	Faculty of Medicine (UI)
dc.contributor.department	Læknadeild (HÍ)
dc.contributor.school	Heilbrigðisvísindasvið (HÍ)
dc.contributor.school	School of Health Sciences (UI)