Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

Vojinovic, Dina; Adams, Hieab H.; Jian, Xueqiu; Yang, Qiong; Smith, Albert Vernon; Bis, Joshua C.; Teumer, Alexander; Scholz, Markus; Armstrong, Nicola J.; Hofer, Edith; Saba, Yasaman; Luciano, Michelle; Bernard, Manon; Trompet, Stella; Yang, Jingyun; Gillespie, Nathan A.; van der Lee, Sven J.; Neumann, Alexander; Ahmad, Shahzad; Andreassen, Ole A.; Ames, David; Amin, Najaf; Arfanakis, Konstantinos; Bastin, Mark E.; Becker, Diane M.; Beiser, Alexa S.; Beyer, Frauke; Brodaty, Henry; Bryan, R. Nick; Bülow, Robin; Dale, Anders M.; De Jager, Philip L.; Deary, Ian J.; DeCarli, Charles; Fleischman, Debra A.; Gottesman, Rebecca F.; van der Grond, Jeroen; Gudnason, Vilmundur; Harris, Tamara B.; Homuth, Georg; Knopman, David S.; Kwok, John B.; Lewis, Cora E.; Li, Shuo; Loeffler, Markus; Lopez, Oscar L.; Maillard, Pauline; El Marroun, Hanan; Mather, Karen A.; Mosley, Thomas H.; Muetzel, Ryan L.; Nauck, Matthias; Nyquist, Paul A.; Panizzon, Matthew S.; Pausova, Zdenka; Psaty, Bruce M.; Rice, Ken; Rotter, Jerome I.; Royle, Natalie; Satizabal, Claudia L.; Schmidt, Reinhold; Schofield, Peter R.; Schreiner, Pamela J.; Sidney, Stephen; Stott, David J.; Thalamuthu, Anbupalam; Uitterlinden, Andre G.; Valdés Hernández, Maria C.; Vernooij, Meike W.; Wen, Wei; White, Tonya; Witte, A. Veronica; Wittfeld, Katharina; Wright, Margaret J.; Yanek, Lisa R.; Tiemeier, Henning; Kremen, William S.; Bennett, David A.; Jukema, J. Wouter; Paus, Tomas; Wardlaw, Joanna M.; Schmidt, Helena; Sachdev, Perminder S.; Villringer, Arno; Grabe, Hans Jörgen; Longstreth, W T; van Duijn, Cornelia M.; Launer, Lenore J.; Seshadri, Sudha; Ikram, M Arfan; Fornage, Myriam

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Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

Titill:	Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume
Höfundur:	Vojinovic, Dina Adams, Hieab H. Jian, Xueqiu Yang, Qiong Smith, Albert Vernon orcid.org/0000-0003-1942-5845 Bis, Joshua C. Teumer, Alexander Scholz, Markus Armstrong, Nicola J. Hofer, Edith ... 81 fleiri höfundar Sýna alla höfunda Saba, Yasaman Luciano, Michelle Bernard, Manon Trompet, Stella Yang, Jingyun Gillespie, Nathan A. van der Lee, Sven J. Neumann, Alexander Ahmad, Shahzad Andreassen, Ole A. Ames, David Amin, Najaf Arfanakis, Konstantinos Bastin, Mark E. Becker, Diane M. Beiser, Alexa S. Beyer, Frauke Brodaty, Henry Bryan, R. Nick Bülow, Robin Dale, Anders M. De Jager, Philip L. Deary, Ian J. DeCarli, Charles Fleischman, Debra A. Gottesman, Rebecca F. van der Grond, Jeroen Gudnason, Vilmundur orcid.org/0000-0001-5696-0084 Harris, Tamara B. Homuth, Georg Knopman, David S. Kwok, John B. Lewis, Cora E. Li, Shuo Loeffler, Markus Lopez, Oscar L. Maillard, Pauline El Marroun, Hanan Mather, Karen A. Mosley, Thomas H. Muetzel, Ryan L. Nauck, Matthias Nyquist, Paul A. Panizzon, Matthew S. Pausova, Zdenka Psaty, Bruce M. Rice, Ken Rotter, Jerome I. Royle, Natalie Satizabal, Claudia L. Schmidt, Reinhold Schofield, Peter R. Schreiner, Pamela J. Sidney, Stephen Stott, David J. Thalamuthu, Anbupalam Uitterlinden, Andre G. Valdés Hernández, Maria C. Vernooij, Meike W. Wen, Wei White, Tonya Witte, A. Veronica Wittfeld, Katharina Wright, Margaret J. Yanek, Lisa R. Tiemeier, Henning Kremen, William S. Bennett, David A. Jukema, J. Wouter Paus, Tomas Wardlaw, Joanna M. Schmidt, Helena Sachdev, Perminder S. Villringer, Arno Grabe, Hans Jörgen Longstreth, W T van Duijn, Cornelia M. Launer, Lenore J. Seshadri, Sudha Ikram, M Arfan Fornage, Myriam 91 höfundar Sýna færri höfunda
Útgáfa:	2018-09-26
Tungumál:	Enska
Umfang:	3945
Háskóli/Stofnun:	Háskóli Íslands (HÍ) University of Iceland (UI)
Svið:	Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI)
Deild:	Faculty of Medicine (UI) Læknadeild (HÍ)
Birtist í:	Nature Communications;9(1)
ISSN:	2041-1723
DOI:	10.1038/s41467-018-06234-w
Efnisorð:	Brain; Enlargement; Genomes; Elderly people; Ventricle (lateral); Mental disorders; Genetics of the nervous system; Genome-wide association studies; Heritable quantitative trait; Erfðafræði; Rannsóknir; Heilinn; Litningarannsóknir
URI:	https://hdl.handle.net/20.500.11815/1391
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Tilvitnun: Vojinovic, D., Adams, H.H., Jian, X. et al. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nat Commun 9, 3945 (2018) doi:10.1038/s41467-018-06234-w
Útdráttur: The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρgenetic = −0.59, p-value = 3.14 × 10−6), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology.
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