Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

Almenn færsla
dc.contributorHáskóli Íslands (HÍ)en_US
dc.contributorUniversity of Iceland (UI)en_US
dc.contributor.authorVojinovic, Dina
dc.contributor.authorAdams, Hieab H.
dc.contributor.authorJian, Xueqiu
dc.contributor.authorYang, Qiong
dc.contributor.authorSmith, Albert Vernon
dc.contributor.authorBis, Joshua C.
dc.contributor.authorTeumer, Alexander
dc.contributor.authorScholz, Markus
dc.contributor.authorArmstrong, Nicola J.
dc.contributor.authorHofer, Edith
dc.contributor.authorSaba, Yasaman
dc.contributor.authorLuciano, Michelle
dc.contributor.authorBernard, Manon
dc.contributor.authorTrompet, Stella
dc.contributor.authorYang, Jingyun
dc.contributor.authorGillespie, Nathan A.
dc.contributor.authorvan der Lee, Sven J.
dc.contributor.authorNeumann, Alexander
dc.contributor.authorAhmad, Shahzad
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorAmes, David
dc.contributor.authorAmin, Najaf
dc.contributor.authorArfanakis, Konstantinos
dc.contributor.authorBastin, Mark E.
dc.contributor.authorBecker, Diane M.
dc.contributor.authorBeiser, Alexa S.
dc.contributor.authorBeyer, Frauke
dc.contributor.authorBrodaty, Henry
dc.contributor.authorBryan, R. Nick
dc.contributor.authorBülow, Robin
dc.contributor.authorDale, Anders M.
dc.contributor.authorDe Jager, Philip L.
dc.contributor.authorDeary, Ian J.
dc.contributor.authorDeCarli, Charles
dc.contributor.authorFleischman, Debra A.
dc.contributor.authorGottesman, Rebecca F.
dc.contributor.authorvan der Grond, Jeroen
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorHomuth, Georg
dc.contributor.authorKnopman, David S.
dc.contributor.authorKwok, John B.
dc.contributor.authorLewis, Cora E.
dc.contributor.authorLi, Shuo
dc.contributor.authorLoeffler, Markus
dc.contributor.authorLopez, Oscar L.
dc.contributor.authorMaillard, Pauline
dc.contributor.authorEl Marroun, Hanan
dc.contributor.authorMather, Karen A.
dc.contributor.authorMosley, Thomas H.
dc.contributor.authorMuetzel, Ryan L.
dc.contributor.authorNauck, Matthias
dc.contributor.authorNyquist, Paul A.
dc.contributor.authorPanizzon, Matthew S.
dc.contributor.authorPausova, Zdenka
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorRice, Ken
dc.contributor.authorRotter, Jerome I.
dc.contributor.authorRoyle, Natalie
dc.contributor.authorSatizabal, Claudia L.
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorSchofield, Peter R.
dc.contributor.authorSchreiner, Pamela J.
dc.contributor.authorSidney, Stephen
dc.contributor.authorStott, David J.
dc.contributor.authorThalamuthu, Anbupalam
dc.contributor.authorUitterlinden, Andre G.
dc.contributor.authorValdés Hernández, Maria C.
dc.contributor.authorVernooij, Meike W.
dc.contributor.authorWen, Wei
dc.contributor.authorWhite, Tonya
dc.contributor.authorWitte, A. Veronica
dc.contributor.authorWittfeld, Katharina
dc.contributor.authorWright, Margaret J.
dc.contributor.authorYanek, Lisa R.
dc.contributor.authorTiemeier, Henning
dc.contributor.authorKremen, William S.
dc.contributor.authorBennett, David A.
dc.contributor.authorJukema, J. Wouter
dc.contributor.authorPaus, Tomas
dc.contributor.authorWardlaw, Joanna M.
dc.contributor.authorSchmidt, Helena
dc.contributor.authorSachdev, Perminder S.
dc.contributor.authorVillringer, Arno
dc.contributor.authorGrabe, Hans Jörgen
dc.contributor.authorLongstreth, W T
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorIkram, M Arfan
dc.contributor.authorFornage, Myriam
dc.contributor.departmentFaculty of Medicine (UI)en_US
dc.contributor.departmentLæknadeild (HÍ)en_US
dc.contributor.schoolHeilbrigðisvísindasvið (HÍ)en_US
dc.contributor.schoolSchool of Health Sciences (UI)en_US
dc.date.accessioned2019-12-16T11:25:22Z
dc.date.available2019-12-16T11:25:22Z
dc.date.issued2018-09-26
dc.descriptionPublisher's version (útgefin grein) Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.en_US
dc.description.abstractThe volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρgenetic = −0.59, p-value = 3.14 × 10−6), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology.en_US
dc.description.sponsorshipSee Supplementary Note 2 for information on funding sources.en_US
dc.description.versionPeer Revieweden_US
dc.format.extent3945en_US
dc.identifier.citationVojinovic, D., Adams, H.H., Jian, X. et al. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nat Commun 9, 3945 (2018) doi:10.1038/s41467-018-06234-wen_US
dc.identifier.doi10.1038/s41467-018-06234-w
dc.identifier.issn2041-1723
dc.identifier.journalNature Communicationsen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11815/1391
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/201413en_US
dc.relation.ispartofseriesNature Communications;9(1)
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrainen_US
dc.subjectEnlargementen_US
dc.subjectGenomesen_US
dc.subjectElderly peopleen_US
dc.subjectVentricle (lateral)en_US
dc.subjectMental disordersen_US
dc.subjectGenetics of the nervous systemen_US
dc.subjectGenome-wide association studiesen_US
dc.subjectHeritable quantitative traiten_US
dc.subjectErfðafræðien_US
dc.subjectRannsókniren_US
dc.subjectHeilinnen_US
dc.subjectLitningarannsókniren_US
dc.titleGenome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volumeen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dcterms.licenseOpen Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US

Skrár

Original bundle

Niðurstöður 1 - 2 af 2
Thumbnail Image
Nafn:
Genome-wide_association_study_.pdf
Stærð:
1.94 MB
Snið:
Adobe Portable Document Format
Description:
Publisher´s version
Hlaða niður
Thumbnail Image
Nafn:
Supplementary Information 41467_2018_6234_MOESM1_ESM.pdf
Stærð:
1.97 MB
Snið:
Adobe Portable Document Format
Description:
Hlaða niður

Undirflokkur

Greinar- HÍ

Öll gögn í Opnum vísindum eru vernduð af ákvæðum höfundalaga og með öllum réttindum áskildum, nema annað sé tekið fram.