Opin vísindi

Fish Intake in Pregnancy and Offspring Metabolic Parameters at Age 9–16—Does Gestational Diabetes Modify the Risk?

Show simple item record

dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Maslova, Ekaterina
dc.contributor.author Hansen, Susanne
dc.contributor.author Strøm, Marin
dc.contributor.author Halldorsson, Thorhallur
dc.contributor.author Grunnet, Louise
dc.contributor.author Vaag, Allan
dc.contributor.author Olsen, Sjurdur F.
dc.date.accessioned 2019-12-04T13:35:26Z
dc.date.available 2019-12-04T13:35:26Z
dc.date.issued 2018-10-17
dc.identifier.citation Maslova, E.; Hansen, S.; Strøm, M.; Halldorsson, T.I.; Grunnet, L.G.; Vaag, A.A.; Olsen, S.F. Fish Intake in Pregnancy and Offspring Metabolic Parameters at Age 9–16—Does Gestational Diabetes Modify the Risk? Nutrients 2018, 10, 1534.
dc.identifier.issn 2072-6643
dc.identifier.uri https://hdl.handle.net/20.500.11815/1365
dc.description Publisher's version (útgefin grein)
dc.description.abstract Oily fish, an important source of marine n-3 long-chain polyunsaturated fatty acids (LCPUFA), has shown to reduce cardiometabolic risk in adults. Whether maternal fish intake affects offspring metabolic health is less established, especially among high-risk pregnancies. We aimed to examine the association of fish intake in pregnancy with offspring metabolic health who were either exposed or unexposed to gestational diabetes mellitus (GDM). Our study included 1234 mother-offspring dyads (608 with a GDM index pregnancy and 626 control dyads) nested within the Danish National Birth Cohort, which is a prebirth cohort. Maternal seafood and marine n-3 LCPUFA consumption was quantified by a food frequency questionnaire (gestational week 25) and a sub-sample with interview data (weeks 12 and 30). The offspring were clinically examined at 9–16 years, including a Dual energy X-ray Absorptiometry (DXA) scan and a fasting blood sample. We calculated multivariable effect estimates and 95% confidence intervals (CI) for anthropometric, adiposity, and metabolic parameters. The median (IQR) intake of total seafood was 23(24) g/day. We found largely no association for total seafood and marine n-3 LCPUFA with offspring metabolic parameters in either group. Using interview data, GDM-exposed women reporting no fish in week 12 and 30 (versus intake >2 times/week) had offspring with a higher Body Mass Index (BMI) (ratio of geometric means (RGM): 1.28, 95% CI: 1.06, 1.55), waist circumference (RGM: 1.22, 95% CI: 1.05, 1.40), triglycerides (RGM: 1.77, 95% CI: 1.03, 3.03), and homeostatic model assessment of insulin resistance HOMA-IR (RGM: 2.16, 95% CI: 1.17, 3.97). We found no associations of n-3 LCPUFA and seafood intake with offspring metabolic outcomes. However, GDM-exposed women who consistently reported eating no fish had offspring with a poorer metabolic profile. Fish intake in pregnancy may mitigate some adverse effects of intrauterine hyperglycemia, however, these findings need replication in better powered studies.
dc.description.sponsorship This work was part of the project “Long-term effects of early nutrition on later health” supported by the European Commission (Project No.: FP7-289346-EarlyNutrition). E.M. was supported by a fellowship grant from the Danish Diabetes Academy supported by the Novo Nordisk Foundation. Further funding for the data collections was provided by grants from the Danish Council for Strategic Research (09-067124 (Centre for Fetal Programming) and 09-075611); the Innovation Fund Denmark (11-115923) and Rigshospitalet, Copenhagen University Hospital.
dc.format.extent 1534
dc.language.iso en
dc.publisher MDPI AG
dc.relation info:eu-repo/grantAgreement/EC/FP7/289346
dc.relation.ispartofseries Nutrients;10(10)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Pregnancy
dc.subject Cohort
dc.subject Fish
dc.subject Adiposity
dc.subject HOMA-IR
dc.subject GDM
dc.subject Meðganga
dc.subject Fjölómettaðar fitusýrur
dc.subject Mataræði
dc.subject Fiskur
dc.title Fish Intake in Pregnancy and Offspring Metabolic Parameters at Age 9–16—Does Gestational Diabetes Modify the Risk?
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.description.version Peer Reviewed
dc.identifier.journal Nutrients
dc.identifier.doi 10.3390/nu10101534
dc.relation.url http://www.mdpi.com/2072-6643/10/10/1534/pdf
dc.contributor.department Matvæla- og næringarfræðideild (HÍ)
dc.contributor.department Faculty of Food Science and Nutrition (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

Files in this item

This item appears in the following Collection(s)

Show simple item record