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Dietary intake is associated with risk of multiple myeloma and its precursor disease

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Thordardottir, Marianna
dc.contributor.author Lindqvist, Ebba K.
dc.contributor.author Lund, Sigrún Helga
dc.contributor.author Costello, Rene
dc.contributor.author Burton, Debra
dc.contributor.author Steingrimsdottir, Laufey
dc.contributor.author Korde, Neha
dc.contributor.author Mailankody, Sham
dc.contributor.author Eiriksdottir, Gudny
dc.contributor.author Launer, Lenore J.
dc.contributor.author Gudnason, Vilmundur
dc.contributor.author Harris, Tamara B.
dc.contributor.author Landgren, Ola
dc.contributor.author Torfadottir, Johanna
dc.contributor.author Kristinsson, Sigurður Yngvi
dc.date.accessioned 2019-11-26T15:43:11Z
dc.date.available 2019-11-26T15:43:11Z
dc.date.issued 2018-11-01
dc.identifier.citation Thordardottir, M., Lindqvist, E. K., Lund, S. H., Costello, R., Burton, D., Steingrimsdottir, L., . . . Kristinsson, S. Y. (2018). Dietary intake is associated with risk of multiple myeloma and its precursor disease. PLoS One, 13(11), e0206047. doi:10.1371/journal.pone.0206047
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/20.500.11815/1360
dc.description Publisher's version (útgefin grein)
dc.description.abstract The etiology of monoclonal gammopathy of undetermined significance (MGUS), the precursor state of multiple myeloma (MM), is mostly unknown and no studies have been conducted on the effect of diet on MGUS or progression from MGUS to MM. We aimed to explore the association between common foods and MGUS and progression to MM. Data from the population-based AGES Study (N = 5,764) were utilized. Food frequency questionnaire was used to assess dietary intake during adolescence, midlife, and late life. Serum protein electrophoresis and serum free light-chain assay was performed to identify MGUS (n = 300) and LC-MGUS cases (n = 275). We cross linked our data with the Icelandic Cancer Registry to find cases of MM in the study group. We found that intake of fruit at least three times per week during adolescence was associated with lower risk of MGUS when compared to lower fruit consumption (OR = 0.62, 95% CI 0.41–0.95). We additionally found that intake of fruit at least three times per week during the late life period was associated with decreased risk of progressing from MGUS to MM (HR = 0.34, 95% CI 0.13–0.89) when compared to lower intake. Adolescent intake of fruit may reduce risk of MGUS, whereas fruit intake after MGUS onset may reduce risk of progressing to MM. Our findings suggest that diet might alter the risk of developing MGUS and progression to MM.
dc.description.sponsorship The AGES-Reykjavik Study was funded by NIH contract N01-AG-012100, the Intramural Research Program of the National Institute on Aging, by the Icelandic Heart Association, and the Icelandic Parliament. This work was supported by the Icelandic Centre for Research, RANNIS (S.Y. Kristinsson), the Landspitali University Hospital Research Fund (S.Y. Kristinsson), the Karolinska Instituted Foundations (S.Y. Kristinsson), the Marie Curie CIG (S.Y. Kristinsson), and the Memorial Sloan Kettering Core Grant (P30 CA008748) from the National Cancer Institute (O.Landgren). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.extent e0206047
dc.language.iso en
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartofseries PLOS ONE;13(11)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Multiple myeloma
dc.subject Diet
dc.subject Food
dc.subject Bread
dc.subject Fruits
dc.subject Food consumption
dc.subject Meat
dc.subject Mergæxli
dc.subject Matvæli
dc.subject Brauð
dc.subject Ávextir
dc.subject Kjöt
dc.subject Mataræði
dc.title Dietary intake is associated with risk of multiple myeloma and its precursor disease
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
dc.description.version Peer Reviewed
dc.identifier.journal Plos One
dc.identifier.doi 10.1371/journal.pone.0206047
dc.relation.url http://dx.plos.org/10.1371/journal.pone.0206047
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.department Miðstöð í lýðheilsuvísindum (HÍ)
dc.contributor.department The Centre of Public Health Sciences (UI)
dc.contributor.department Matvæla- og næringarfræðideild (HÍ)
dc.contributor.department Faculty of Food Science and Nutrition (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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