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Preeclampsia and academic performance in children: A nationwide study from Iceland

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Sverrisson, Friðgeir A.
dc.contributor.author Bateman, Brian T.
dc.contributor.author Aspelund, Thor
dc.contributor.author Skúlason, Sigurgrímur
dc.contributor.author Zoega, Helga
dc.date.accessioned 2019-09-23T14:08:55Z
dc.date.available 2019-09-23T14:08:55Z
dc.date.issued 2018-11-21
dc.identifier.citation Sverrisson FA, Bateman BT, Aspelund T, Skulason S, Zoega H (2018) Preeclampsia and academic performance in children: A nationwide study from Iceland. PLoS ONE 13(11): e0207884. https://doi.org/10.1371/journal.pone.0207884
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/20.500.11815/1259
dc.description Publisher's version (útgefin grein)
dc.description.abstract Background Hypertensive disorders complicate up to 10% of pregnancies. Evidence suggests a potential association between maternal hypertensive disorders during pregnancy, particularly preeclampsia, and adverse neurodevelopment in the offspring, but existing studies are subject to limitations. We aimed to assess whether in-utero exposure to preeclampsia/eclampsia negatively impacts academic performance at ages 9, 12 and 15 years. Methods Using individually linked, nationwide data from the Icelandic registries we followed all children born in 1989–2004 (N = 68,580), from birth until the end of 2014, thereof 63,014 (91.9%) took at least one standardized test. Using a stepwise, mixed-effects approach, we modelled the hypothesized relationship while adjusting for maternal, perinatal and childhood variables of interest. We compared test scores, measured on a normalized scale ranging from 0–60 with a mean of 30 and a standard deviation of 10, in the 4th, 7th, and 10th grades, between children exposed to preeclampsia or eclampsia in-utero versus children from normotensive pregnancies in the population. Results Children exposed to preeclampsia/eclampsia scored lower than those unexposed in mathematics across all grade levels, corresponding to a difference of 0.44 points (95% CI: 0.00, 0.89), 0.59 points (95% CI: 0.13, 1.06) and 0.59 points (95% CI: 0.08, 1.10), respectively. No differences were observed in the language arts. Conclusions Our findings suggest a minimal effect of maternal preeclampsia/eclampsia on children’s academic performance at ages 9, 12 and 15 years. The differences observed in mathematic scores between exposed and unexposed children were minimal, less than one tenth of a standard deviation per measurement occasion.
dc.description.sponsorship HZ received financial support for this study from the Icelandic Centre for Research, START – Reintegration fellowship, under Award Number 130814-051, http://www.rannis.is. BTB was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (Bethesda, Maryland, United States) under Award Number K08HD075831. Dr. Helga Zoega was supported by a Scientia Fellowship awarded by the University of New South Wales. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.extent e0207884
dc.language.iso en
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartofseries Plos One;13(11)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Hypertensive disorders in pregnancy
dc.subject Preeclampsia
dc.subject ADHD
dc.subject Birth
dc.subject Pediatrics
dc.subject Academic skills
dc.subject Háþrýstingur
dc.subject Meðganga
dc.subject Menntun
dc.subject Færni
dc.subject Börn
dc.title Preeclampsia and academic performance in children: A nationwide study from Iceland
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.version Peer Reviewed
dc.identifier.journal Plos One
dc.identifier.doi 10.1371/journal.pone.0207884
dc.relation.url http://dx.plos.org/10.1371/journal.pone.0207884
dc.contributor.department Miðstöð í lýðheilsuvísindum (HÍ)
dc.contributor.department The Centre of Public Health Sciences (UI)
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.department Sálfræðideild (HÍ)
dc.contributor.department Faculty of Psychology (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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