Opin vísindi

GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures

Show simple item record

dc.contributor Háskólinn á Akureyri
dc.contributor University of Akureyri
dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Styrkarsdottir, Unnur
dc.contributor.author Stefansson, Olafur A.
dc.contributor.author Gunnarsdottir, Kristbjorg
dc.contributor.author Thorleifsson, Gudmar
dc.contributor.author Lund, Sigrún Helga
dc.contributor.author Stefansdottir, Lilja
dc.contributor.author Juliusson, Kristinn
dc.contributor.author Ágústsdóttir, Arna B.
dc.contributor.author Zink, Florian
dc.contributor.author Halldorsson, Gisli
dc.contributor.author Ivarsdottir, Erna V.
dc.contributor.author Benonisdottir, Stefania
dc.contributor.author Jonsson, Hakon
dc.contributor.author Gylfason, Arnaldur
dc.contributor.author Norland, Kristjan
dc.contributor.author Trajanoska, Katerina
dc.contributor.author Boer, Cindy G.
dc.contributor.author Southam, Lorraine
dc.contributor.author Leung, Jason C. S.
dc.contributor.author Tang, Nelson L. S.
dc.contributor.author Kwok, Timothy C. Y.
dc.contributor.author Lee, Jenny S. W.
dc.contributor.author Ho, Suzanne C.
dc.contributor.author Byrjalsen, Inger
dc.contributor.author Center, Jacqueline R.
dc.contributor.author Lee, Seung Hun
dc.contributor.author Koh, Jung-Min
dc.contributor.author Lohmander, L. Stefan
dc.contributor.author Ho-Pham, Lan T.
dc.contributor.author Nguyen, Tuan V.
dc.contributor.author Eisman, John A.
dc.contributor.author Woo, Jean
dc.contributor.author Leung, Ping-C.
dc.contributor.author Loughlin, John
dc.contributor.author Zeggini, Eleftheria
dc.contributor.author Christiansen, Claus
dc.contributor.author Rivadeneira, Fernando
dc.contributor.author van Meurs, Joyce
dc.contributor.author Uitterlinden, Andre G.
dc.contributor.author Mogensen, Brynjólfur
dc.contributor.author Jonsson, Helgi
dc.contributor.author Ingvarsson, Þorvaldur
dc.contributor.author Sigurdsson, Gunnar
dc.contributor.author Benediktsson, Rafn
dc.contributor.author sulem, patrick
dc.contributor.author Jonsdottir, Ingileif
dc.contributor.author Másson, Gísli
dc.contributor.author Holm, Hilma
dc.contributor.author Norddahl, Gudmundur L.
dc.contributor.author Thorsteinsdottir, Unnur
dc.contributor.author Gudbjartsson, Daniel
dc.contributor.author Stefansson, Kari
dc.date.accessioned 2019-05-17T13:36:23Z
dc.date.available 2019-05-17T13:36:23Z
dc.date.issued 2019-05-03
dc.identifier.citation Styrkarsdottir, U., Stefansson, O. A., Gunnarsdottir, K., Thorleifsson, G., Lund, S. H., Stefansdottir, L., . . . Stefansson, K. (2019). GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures. Nature Communications, 10(1), 2054. doi:10.1038/s41467-019-09860-0
dc.identifier.issn 2041-1723
dc.identifier.uri https://hdl.handle.net/20.500.11815/1171
dc.description.abstract Bone area is one measure of bone size that is easily derived from dual-energy X-ray absorptiometry (DXA) scans. In a GWA study of DXA bone area of the hip and lumbar spine (N ≥ 28,954), we find thirteen independent association signals at twelve loci that replicate in samples of European and East Asian descent (N = 13,608 – 21,277). Eight DXA area loci associate with osteoarthritis, including rs143384 in GDF5 and a missense variant in COL11A1 (rs3753841). The strongest DXA area association is with rs11614913[T] in the microRNA MIR196A2 gene that associates with lumbar spine area (P = 2.3 × 10−42, β = −0.090) and confers risk of hip fracture (P = 1.0 × 10−8, OR = 1.11). We demonstrate that the risk allele is less efficient in repressing miR-196a-5p target genes. We also show that the DXA area measure contributes to the risk of hip fracture independent of bone density.
dc.description.sponsorship We thank all the study subjects for their valuable participation, the staff from all studies and the participating physicians. A part of this research has been conducted using the UK Biobank Resource under Application Number 23359. arcOGEN (http://www.arcogen.org.uk/) was funded by a special purpose grant from Arthritis Research UK (grant 18030). Members of the arcOGEN Consortium are given in the Supplementary Note 3. Full acknowledgments are given in the Supplementary Note 4.
dc.format.extent 2054
dc.language.iso en
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartofseries Nature Communications;10(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Genetics
dc.subject Fractures
dc.subject Osteoarthritis
dc.subject Erfðafræði
dc.subject Beinbrot
dc.subject Slitgigt
dc.title GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
dc.type info:eu-repo/semantics/article
dcterms.license This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.description.version Peer reviewed
dc.identifier.journal Nature Communications
dc.identifier.doi 10.1038/s41467-019-09860-0
dc.contributor.department Heilbrigðisvísindastofnun (HA)
dc.contributor.department Research Centre for Health Science (UA)
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HA)
dc.contributor.school School of Health Sciences (UA)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

Files in this item

This item appears in the following Collection(s)

Show simple item record