Opin vísindi

Age and Influenza-Specific Pre-Vaccination Antibodies Strongly Affect Influenza Vaccine Responses in the Icelandic Population whereas Disease and Medication Have Small Effects

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Ólafsdóttir, Þórunn Ásta
dc.contributor.author Alexandersson, Kristján F.
dc.contributor.author Sveinbjornsson, Gardar
dc.contributor.author Lapini, Giulia
dc.contributor.author Palladino, Laura
dc.contributor.author Montomoli, Emanuele
dc.contributor.author Del Giudice, Giuseppe
dc.contributor.author Gudbjartsson, Daniel
dc.contributor.author Jonsdottir, Ingileif
dc.date.accessioned 2019-04-17T12:38:32Z
dc.date.available 2019-04-17T12:38:32Z
dc.date.issued 2018-01-08
dc.identifier.citation Olafsdottir, T. A., Alexandersson, K. F., Sveinbjornsson, G., Lapini, G., Palladino, L., Montomoli, E., . . . Jonsdottir, I. (2018). Age and Influenza-Specific Pre-Vaccination Antibodies Strongly Affect Influenza Vaccine Responses in the Icelandic Population whereas Disease and Medication Have Small Effects. Frontiers in Immunology, 8(1872). doi:10.3389/fimmu.2017.01872
dc.identifier.issn 1664-3224
dc.identifier.uri https://hdl.handle.net/20.500.11815/1119
dc.description Publisher's version (útgefin grein)
dc.description.abstract Influenza vaccination remains the best strategy for the prevention of influenza virus-related disease and reduction of disease severity and mortality. However, there is large individual variation in influenza vaccine responses. In this study, we investigated the effects of gender, age, underlying diseases, and medication on vaccine responses in 1,852 Icelanders of broad age range who received trivalent inactivated influenza virus vaccination in 2012, 2013, or 2015. Hemagglutination inhibition (HAI) and microneutralization (MN) titers were measured in pre- and post-vaccination sera. Of the variables tested, the strongest association was with level of pre-vaccination titer that explained a major part of the variance observed in post-vaccination titers, ranging from 19 to 29%, and from 7 to 21% in fold change (FC), depending on the strain and serological (HAI or MN) analysis performed. Thus, increasing pre-vaccination titer associated with decreasing FC (P = 1.1 × 10−99–8.6 × 10−30) and increasing post-vaccination titer (P = 2.1 × 10−159–1.1 × 10−123). Questionnaires completed by 87% of the participants revealed that post-vaccination HAI titer showed association with repeated previous influenza vaccinations. Gender had no effect on vaccine response whereas age had a strong effect and explained 1.6–3.1% of HAI post-vaccination titer variance and 3.1% of H1N1 MN titer variance. Vaccine response, both fold increase and seroprotection rate (percentage of individuals reaching HAI ≥ 40 or MN ≥ 20), was higher in vaccinees ≤37 years of age (YoA) than all other age groups. Furthermore, a reduction was observed in the H1N1 MN titer in people ≥63 YoA, demonstrating a decreased neutralizing functionality of vaccine-induced antibodies at older age. We tested the effects of underlying autoimmune diseases, asthma and allergic diseases and did not observe significant associations with vaccine responses. Intake of immune modulating medication did not show any association. Taken together, our results show that previous encounter of influenza vaccination or infection, reflected in high HAI and MN pre-vaccination titer has the strongest negative effect on vaccine responses measured as FC and the strongest positive effect on post-vaccination titer. Increasing age had also an effect but not gender, underlying disease or medication.
dc.description.sponsorship This research was funded in part by the European Union’s Seventh Framework Program “ADITEC” (EU FP7/2007-2013, grant agreement no: 280873).
dc.format.extent 1872
dc.language.iso en
dc.publisher Frontiers Media SA
dc.relation info:eu-repo/grantAgreement/EC/FP7/280873
dc.relation.ispartofseries Frontiers in Immunology;8
dc.rights info:eu-repo/semantics/openAccess
dc.subject Influenza vaccine
dc.subject Pre-vaccination antibody titer
dc.subject Age effect
dc.subject Underlying diseases
dc.subject Medication
dc.subject Inflúensa
dc.subject Bólusetningar
dc.subject Aldurshópar
dc.title Age and Influenza-Specific Pre-Vaccination Antibodies Strongly Affect Influenza Vaccine Responses in the Icelandic Population whereas Disease and Medication Have Small Effects
dc.type info:eu-repo/semantics/article
dcterms.license This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.description.version Peer Reviewed
dc.identifier.journal Frontiers in Immunology
dc.identifier.doi 10.3389/fimmu.2017.01872
dc.relation.url http://journal.frontiersin.org/article/10.3389/fimmu.2017.01872/full
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)
dc.contributor.school Verkfræði- og náttúruvísindasvið (HÍ)
dc.contributor.school School of Engineering and Natural Sciences (UI)

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