Opin vísindi

A three-generation study on the association of tobacco smoking with asthma

Show simple item record

dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Accordini, Simone
dc.contributor.author Calciano, Lucia
dc.contributor.author Johannessen, Ane
dc.contributor.author Portas, Laura
dc.contributor.author Benediktsdóttir, Bryndís
dc.contributor.author Bertelsen, Randi Jacobsen
dc.contributor.author Bråbäck, Lennart
dc.contributor.author Carsin, Anne-Elie
dc.contributor.author Dharmage, Shyamali C
dc.contributor.author Dratva, Julia
dc.contributor.author Forsberg, Bertil
dc.contributor.author Gomez Real, Francisco
dc.contributor.author Heinrich, Joachim
dc.contributor.author Holloway, John W
dc.contributor.author Holm, Mathias
dc.contributor.author Janson, Christer
dc.contributor.author Jögi, Rain
dc.contributor.author Leynaert, Bénédicte
dc.contributor.author Malinovschi, Andrei
dc.contributor.author Marcon, Alessandro
dc.contributor.author Martínez-Moratalla Rovira, Jesús
dc.contributor.author Raherison, Chantal
dc.contributor.author Sánchez-Ramos, José Luis
dc.contributor.author Schlünssen, Vivi
dc.contributor.author Bono, Roberto
dc.contributor.author Corsico, Angelo G
dc.contributor.author Demoly, Pascal
dc.contributor.author Dorado Arenas, Sandra
dc.contributor.author Nowak, Dennis
dc.contributor.author Pin, Isabelle
dc.contributor.author Weyler, Joost
dc.contributor.author Jarvis, Deborah
dc.contributor.author Svanes, Cecilie
dc.date.accessioned 2019-04-08T14:18:17Z
dc.date.available 2019-04-08T14:18:17Z
dc.date.issued 2018-03-09
dc.identifier.citation Study, t. A. L. i. E. C., Marcon, A., Portas, L., Calciano, L., Accordini, S., Dharmage, S. C., . . . Carsin, A.-E. (2018). A three-generation study on the association of tobacco smoking with asthma. International Journal of Epidemiology, 47(4), 1106-1117. doi:10.1093/ije/dyy031
dc.identifier.issn 0300-5771
dc.identifier.issn 1464-3685 (eISSN)
dc.identifier.uri https://hdl.handle.net/20.500.11815/1102
dc.description Publisher's version (útgefin grein)
dc.description.abstract Background Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Results Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55). Conclusions Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.
dc.description.sponsorship The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study [www.alecstudy.org], which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633212. The coordination of the European Community Respiratory Health Survey (ECRHS) was supported by the European Commission (phases 1 and 2) and the Medical Research Council (phase 3). Local funding agencies for the ECRHS are reported in the Supplementary Appendix, available as Supplementary data at IJE online. Conflict of interest: J.W.H. reports grants from the European Union’s Horizon 2020 programme (633212), the Medical Research Council UK (MC_PC_15078) and the National Institutes of Health USA (R01 AI091905, R01 AI121226) during the conduct of the study. R.J. reports grants from the Estonian Research Council (personal grant No. 562) during the conduct of the study, grants/grants pending from the Estonian Research Council (personal research grant No. 562), personal fees for consulting and lecturing from GlaxoSmithKline, Boehringer and Novartis and travel/accommodation/meeting expenses paid by GlaxoSmithKline and Boehringer, outside the submitted work. C.R. reports personal fees for consulting and lecturing from ALK, Astra Zeneca, GSK, Boheringer and Novartis, outside the submitted work. A.G.C. reports grants from Chiesi Farmaceutici and GlaxoSmithKline Italy, during the conduct of the study. P.D. reports personal fees for consulting and lecturing from ALK and Stallergenes Greer and personal fees for consulting from Circassia, Chiesi Farmaceutici, ThermofisherScientific and Menarini, outside the submitted work. D.J. reports grants from the Medical Research Council and the European Union’s Horizon 2020 programme, during the conduct of the study. All other authors declare no competing interests.
dc.format.extent 1106-1117
dc.language.iso en
dc.publisher Oxford University Press (OUP)
dc.relation info:eu-repo/grantAgreement/EC/H2020/633212
dc.relation.ispartofseries International Journal of Epidemiology;47(4)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Smoking
dc.subject Asthma
dc.subject Parents
dc.subject Smoking in pregnancy
dc.subject Offspring
dc.subject Reykingar
dc.subject Astmi
dc.subject Foreldrar
dc.subject Meðganga
dc.subject Óbeinar reykingar
dc.title A three-generation study on the association of tobacco smoking with asthma
dc.type info:eu-repo/semantics/article
dcterms.license This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.description.version Peer Reviewed
dc.identifier.journal International Journal of Epidemiology
dc.identifier.doi 10.1093/ije/dyy031
dc.relation.url http://academic.oup.com/ije/article-pdf/47/4/1106/25687458/dyy031.pdf
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

Files in this item

This item appears in the following Collection(s)

Show simple item record