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Dietary habits in adolescence and midlife and risk of breast cancer in older women

Dietary habits in adolescence and midlife and risk of breast cancer in older women

Title: Dietary habits in adolescence and midlife and risk of breast cancer in older women
Author: Haraldsdottir, Alfheidur   orcid.org/0000-0002-0151-8341
Torfadottir, Johanna   orcid.org/0000-0002-9721-0105
Valdimarsdottir, Unnur   orcid.org/0000-0001-5382-946X
Adami, Hans-Olov
Aspelund, Thor   orcid.org/0000-0002-7998-5433
Tryggvadottir, Laufey   orcid.org/0000-0001-8067-9030
Þórðardóttir, Maríanna
Birgisdottir, Bryndis Eva   orcid.org/0000-0002-5788-4551
Harris, Tamara B.
Launer, Lenore J.
... 2 more authors Show all authors
Date: 2018-05-30
Language: English
Scope: e0198017
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Matvæla- og næringarfræðideild (HÍ)
Faculty of Food Science and Nutrition (UI)
Miðstöð í lýðheilsuvísindum (HÍ)
The Centre of Public Health Sciences (UI)
Læknadeild (HÍ)
Faculty of Medicine (UI)
Series: Plos One;13(5)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0198017
Subject: Breast cancer; Meat; Bread; Rye; Breast milk; Milk; Food; Cancer detection and diagnosis; Brjóstakrabbamein; Mataræði; Kjöt; Brauð; Korn; Brjóstamjólk; Krabbameinsleit; Sjúkdómsgreiningar
URI: https://hdl.handle.net/20.500.11815/1056

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Haraldsdottir, A., Torfadottir, J. E., Valdimarsdottir, U. A., Adami, H.-O., Aspelund, T., Tryggvadottir, L., . . . Steingrimsdottir, L. (2018). Dietary habits in adolescence and midlife and risk of breast cancer in older women. PLoS One, 13(5), e0198017. doi:10.1371/journal.pone.0198017


Recent studies indicate that lifestyle factors in early life affect breast cancer risk. We therefore explored the association of high consumption of meat, milk, and whole grain products in adolescence and midlife, on breast cancer risk. We used data from the population based AGES-Reykjavik cohort (2002–2006), where 3,326 women with a mean age of 77 years (SD 6.0) participated. For food items and principal component derived dietary patterns we used Cox proportional models to calculate multivariate hazard ratios (HR) with 95% confidence intervals (95% CI). During a mean follow-up of 8.8 years, 97 women were diagnosed with breast cancer. For both adolescence and midlife, daily consumption of rye bread was positively associated with breast cancer (HR 1.7, 95% CI 1.1–2.6 and HR 1.8, 95% CI 1.1–2.9, respectively). In contrast, persistent high consumption of oatmeal was negatively associated with breast cancer (0.4, 95% CI 0.2–0.9). No association was found for other food items or dietary patterns that included rye bread. High rye bread consumption in adolescence and midlife may increase risk of late-life breast cancer whilst persistent consumption of oatmeal may reduce the risk.


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