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Alkaloid fingerprinting resolves Huperzia selago genotypes in Iceland

Alkaloid fingerprinting resolves Huperzia selago genotypes in Iceland

Title: Alkaloid fingerprinting resolves Huperzia selago genotypes in Iceland
Author: Xu, Maonian   orcid.org/0000-0002-4346-8020
Eiriksson, Finnur Freyr
Thorsteinsdóttir, Margrét   orcid.org/0000-0002-0649-8503
Heiðmarsson, Starri   orcid.org/0000-0003-0329-6882
Omarsdottir, Sesselja   orcid.org/0000-0003-1824-5148
Olafsdottir, Elin Soffia   orcid.org/0000-0001-7305-7129
Date: 2019-04
Language: English
Scope: 77-82
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Lyfjafræðideild (HÍ)
Faculty of Pharmaceutical Sciences (UI)
Series: Biochemical Systematics and Ecology;83
ISSN: 0305-1978
DOI: 10.1016/j.bse.2019.01.009
Subject: Lycopodiaceae; Lycopodium alkaloids; Huperzine A; Phylogeny; Alkaloid fingerprinting; Lyfjafræði; Lyfjaefnafræði; Lífefnafræði; Lyfjagerð; Æðplöntur
URI: https://hdl.handle.net/20.500.11815/1023

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Xu, M., Eiriksson, F. F., Thorsteinsdottir, M., Heidmarsson, S., Omarsdottir, S., & Olafsdottir, E. S. (2019). Alkaloid fingerprinting resolves Huperzia selago genotypes in Iceland. Biochemical Systematics and Ecology, 83, 77-82. doi:https://doi.org/10.1016/j.bse.2019.01.009


The club moss family Lycopodiaceae produces a diverse array of bioactive lycopodium alkaloids (LAs). In particular, the alkaloid huperzine A (hupA) has grasped attention since it is a potent acetylcholinesterase inhibitor of medical interest in Alzheimer's disease. Although the structural diversity and bioactivities of LAs have been studied to some extent, their chemotaxonomic value is mostly unexplored, especially to a lower taxonomic unit (e.g. subspecies or genotypes). This study focused on previously reported Icelandic Huperzia selago genotypes, and aimed to evaluate the chemotaxonomic value of LAs in resolving them. Using liquid chromatography-mass spectrometry (LC-MS), alkaloid fingerprints of H. selago taxa were subjected to principal component analysis (PCA). Our results revealed that each genotype tends to have its own alkaloid profile. Genotype 1 and 3 form distinct groups in a PCA plot, where genotype 2 is an intermediate between the other two genotypes. HupA and its derivative, huperzine B, both contribute to the differentiation of genotype 3 from the others. Therefore, our study demonstrated the potential of alkaloid fingerprints in resolving deep taxonomic groups and selecting plant taxa of medicinal importance.


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