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Browsing by Subject "Molecular Biology"

Browsing by Subject "Molecular Biology"

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  • Memarian, Parastoo; Pishavar, Elham; Zanotti, Federica; Trentini, Martina; Camponogara, Francesca; Soliani, Elisa; Gargiulo, Paolo; Isola, Maurizio; Zavan, Barbara (2022-02-01)
    The successful clinical application of bone tissue engineering requires customized implants based on the receiver’s bone anatomy and defect characteristics. Three-dimensional (3D) printing in small animal orthopedics has recently emerged as a valuable ...
  • Hernandes, Vinicius Verri; Dordevic, Nikola; Hantikainen, Essi Marjatta; Sigurðsson, Baldur Bragi; Smárason, Sigurður Vidir; Garcia-Larsen, Vanessa; Gögele, Martin; Caprioli, Giulia; Bozzolan, Ilaria; Pramstaller, Peter P.; Rainer, Johannes (2022-03)
    Metabolomics in human serum samples provide a snapshot of the current metabolic state of an individuum. Metabolite concentrations are influenced by both genetic and environmental factors. Concentrations of certain metabolites can further depend on age, ...
  • Kamen, Yasmine; Káradóttir, Ragnhildur Þóra (2021-06-18)
    Single-cell electrophysiological recordings combined with dye loading and immunohistochemistry provide unparalleled single-cell resolution of cell physiology, morphology, location, and protein expression. When correlated with bulk RNA sequencing, these ...
  • Guðbrandsson, Jóhannes; Franzdottir, Sigridur Rut; Kristjansson, Bjarni K.; Pashay Ahi, Ehsan; Maier, Valerie H.; Kapralova, Kalina; Snorrason, Sigurður S.; Jónsson, Zophonías Oddur; Palsson, Arnar (PeerJ, 2018-02-07)
    Phenotypic differences between closely related taxa or populations can arise through genetic variation or be environmentally induced, leading to altered transcription of genes during development. Comparative developmental studies of closely related ...
  • Kapralova, Kalina; Guðbrandsson, Jóhannes; Reynisdottir, Sigrun; Santos, Cristina B.; Baltanás, Vanessa C; Maier, Valerie H. untranslated; Snorrason, Sigurður S.; Palsson, Arnar (Public Library of Science (PLoS), 2013-07-24)
    Northern freshwater fish may be suitable for the genetic dissection of ecological traits because they invaded new habitats after the last ice age (∼10.000 years ago). Arctic charr (Salvelinus alpinus) colonizing streams and lakes in Iceland gave rise ...
  • Katrínardóttir, Borgný; Alves, Jose; Sigurjónsdóttir, Hrefna; Hersteinsson, Páll; Gunnarsson, Tomas Gretar (Public Library of Science (PLoS), 2015-07-10)
    Distinct preference of species for habitats is most often driven by long term differences in demographic rates between habitats. Estimating variation in those rates is key for developing successful conservation strategies. Stochastic events can interact ...
  • Stefánsson, Bjarki; Sandholt, Gunnar Birgir; Guðmundsdóttir, Ágústa (Elsevier BV, 2017-01)
    Trypsins from Atlantic cod (Gadus morhua), consisting of several isoenzymes, are highly active cold-adapted serine proteases. These trypsins are isolated for biomedical use in an eco-friendly manner from underutilized seafood by-products. Our group has ...
  • Ahluwalia, Tarunveer S.; Prins, Bram P.; Abdollahi, Mohammadreza; Armstrong, Nicola J.; Aslibekyan, Stella; Bain, Lisa; Jefferis, Barbara; Baumert, Jens; Beekman, Marian; Ben-Shlomo, Yoav; Bis, Joshua C.; Mitchell, Braxton D.; De Geus, Eco; Delgado, Graciela E.; Marek, Diana; Eriksson, Joel; Kajantie, Eero; Kanoni, Stavroula; Kemp, John P.; Lu, Chen; Marioni, Riccardo E.; McLachlan, Stela; Milaneschi, Yuri; Nolte, Ilja M.; Petrelis, Alexandros M.; Porcu, Eleonora; Sabater-Lleal, Maria; Naderi, Elnaz; Seppälä, Ilkka; Shah, Tina; Singhal, Gaurav; Standl, Marie; Teumer, Alexander; Thalamuthu, Anbupalam; Thiering, Elisabeth; Trompet, Stella; Ballantyne, Christie M.; Benjamin, Emelia J.; Casas, Juan P.; Toben, Catherine; Dedoussis, George; Deelen, Joris; Durda, Peter; Engmann, Jorgen; Feitosa, Mary F.; Grallert, Harald; Hammarstedt, Ann; Harris, Sarah E.; Homuth, Georg; Guðnason, Vilmundur G. (2021-01-30)
    Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease ...
  • Ingthorsson, Saevar; Andersen, K; Hilmarsdóttir, Bylgja; Mælandsmo, Gunhild M; Magnusson, Magnus Karl; Gudjonsson, Thorarinn (Springer Nature, 2015-12-21)
    The members of the epidermal growth factor receptor (EGFR) kinase family are important players in breast morphogenesis and cancer. EGFR2/HER2 and EGFR expression have a prognostic value in certain subtypes of breast cancer such as HER2-amplified, ...
  • Gargallo-Garriga, Albert; Ayala-Roque, Marta; Sardans, Jordi; Bartrons, Mireia; Granda, Victor; Sigurdsson, Bjarni D.; Leblans, Niki; Oravec, Michal; Urban, Otmar; Janssens, Ivan; Penuelas, Josep (MDPI AG, 2017-08-23)
    Climate change is stronger at high than at temperate and tropical latitudes. The natural geothermal conditions in southern Iceland provide an opportunity to study the impact of warming on plants, because of the geothermal bedrock channels that induce ...
  • Hetzke, Thilo; Vogel, Marc; Gophane, Dnyaneshwar B.; Weigand, Julia E.; Suess, Beatrix; Sigurdsson, Snorri; Prisner, Thomas F. (Cold Spring Harbor Laboratory, 2018-10-18)
    The tetracycline-binding RNA aptamer (TC-aptamer) is a synthetic riboswitch that binds the antibiotic tetracycline (TC) with exceptionally high affinity. Although a crystal structure exists of the TC-bound state, little is known about the conformational ...
  • Zimta, Alina-Andreea; Sigurjonsson, Olafur Eysteinn; Gulei, Diana; Tomuleasa, Ciprian (MDPI AG, 2020-08-15)
    Nowadays, advancements in the oncology sector regarding diagnosis methods allow us to specifically detect an increased number of cancer patients, some of them in incipient stages. However, one of the main issues consists of the invasive character of ...
  • López García de Lomana, Adrián; Vilhjálmsson, Arnar Ingi; McGarrity, Sarah; Sigurðardóttir, Rósa; Anuforo, Ósk; Viktorsdóttir, Alexía Rós; Kotronoulas, Aris; Bergmann, Andreas; Franzson, Leifur; Halldórsson, Haraldur; Henriksen, Hanne H.; Wade, Charles E.; Johansson, Pär Ingemar; Rolfsson, Óttar (2022-03)
    Disruption to endothelial cell homeostasis results in an extensive variety of human pathologies that are particularly relevant to major trauma. Circulating catecholamines, such as adrenaline and noradrenaline, activate endothelial adrenergic receptors ...
  • Wesolowska, Natalia; Reynisdóttir, Sigrún; Ludwig, Michael Z.; Kreitman, Martin; Palsson, Arnar (Public Library of Science (PLoS), 2014-05-01)
    Changes in regulatory DNA contribute to phenotypic differences within and between taxa. Comparative studies show that many transcription factor binding sites (TFBS) are conserved between species whereas functional studies reveal that some mutations ...
  • Sunds, Anne Vuholm; Roland, Ida Schwartz; Sundekilde, Ulrik Kræmer; Thesbjerg, Martin Nørmark; Robinson, Randall; Bunyatratchata, Apichaya; Glantz, Maria; Paulsson, Marie; Leskauskaite, Daiva; Pihlanto, Anne; Inglingstad, Ragnhild; Devold, Tove Gulbrandsen; Vegarud, Gerd Elisabeth; Birgisdóttir, Bryndís Eva; Guðjónsdóttir, María; Barile, Daniela; Larsen, Lotte Bach; Poulsen, Nina Aagaard (2021-09-28)
    Little is known about the extent of variation and activity of naturally occurring milk glycosidases and their potential to degrade milk glycans. A multi-omics approach was used to investigate the relationship between glycosidases and important bioactive ...
  • Ward, Zoe; Schmeier, Sebastian; Saddic, Louis; Sigurðsson, Martin Ingi; Cameron, Vicky A.; Pearson, John; Miller, Allison; Morley‐bunker, Arthur; Gorham, Josh; Seidman, Jonathan G.; Moravec, Christine S.; Sweet, Wendy E.; Aranki, Sary F.; Body, Simon; Muehlschlegel, Jochen D.; Pilbrow, Anna P. (2021-10-20)
    BACKGROUND: Long noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of cardiovascular diseases. We aimed to identify novel lncRNAs associated with the early response to ischemia in the heart. METHODS AND RESULTS: RNA sequencing data ...
  • Kalkhoran, Siavash Beikoghli; Kararigas, Georgios (2022-02-01)
    Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific ...
  • Kristmundsdottir, Snædis; Eggertsson, Hannes P; Arnadottir, Gudny A; Halldórsson, Bjarni (Oxford University Press (OUP), 2019-12-05)
    Summary: popSTR2 is an update and augmentation of our previous work ‘popSTR: a population-based microsatellite genotyper’. To make genotyping sensitive to inter-sample differences, we supply a kernel to estimate sample-specific slippage rates. For ...
  • Árnason, Níels Árni; Johannsson, Freyr; Landrö, Ragna; Harðarsson, Björn; Guðmundsson, Sveinn; Lian, Aina Mari; Reseland, Janne; Rolfsson, Ottar; Sigurjónsson, Ólafur Eysteinn (2022-03)
    Platelet granules contain a diverse group of proteins. Upon activation and during storage, platelets release a number of proteins into the circulation or supernatant of stored platelet concentrate (PC). The aim of this work was to investigate the effect ...
  • Benonisdottir, Stefania; Kristjansson, Ragnar P; Oddsson, Asmundur; Steinthorsdottir, Valgerdur; Mikaelsdottir, Evgenia; Kehr, Birte; Jensson, Brynjar O; Arnadottir, Gudny A; Sulem, Gerald; Sveinbjornsson, Gardar; Kristmundsdóttir, Snædís; Ívarsdóttir, Erna V.; Tragante, Vinicius; Gunnarsson, Bjarni; Runolfsdottir, Hrafnhildur Linnet; Arthur, Joseph G; Deaton, Aimee M; Eyjolfsson, Gudmundur I; Davidsson, Olafur B; Asselbergs, Folkert W; Hreidarsson, Astradur B; Rafnar, Thorunn; Thorleifsson, Gudmar; Edvardsson, Vidar; Sigurdsson, Gunnar; Helgadottir, Anna; Halldórsson, Bjarni; Masson, Gisli; Holm, Hilma; Önundarson, Páll Torfi; Indridason, Olafur S; Benediktsson, Rafn; Palsson, Runolfur; Gudbjartsson, Daniel F; Olafsson, Isleifur; Thorsteinsdottir, Unnur; sulem, patrick; Stefansson, Kari (Oxford University Press (OUP), 2018-11-24)
    Urine dipstick tests are widely used in routine medical care to diagnose kidney and urinary tract and metabolic diseases. Several environmental factors are known to affect the test results, whereas the effects of genetic diversity are largely unknown. ...