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Browsing by Subject "Molecular Biology"

Browsing by Subject "Molecular Biology"

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  • Memarian, Parastoo; Pishavar, Elham; Zanotti, Federica; Trentini, Martina; Camponogara, Francesca; Soliani, Elisa; Gargiulo, Paolo; Isola, Maurizio; Zavan, Barbara (2022-02-01)
    The successful clinical application of bone tissue engineering requires customized implants based on the receiver’s bone anatomy and defect characteristics. Three-dimensional (3D) printing in small animal orthopedics has recently emerged as a valuable ...
  • Hernandes, Vinicius Verri; Dordevic, Nikola; Hantikainen, Essi Marjatta; Sigurðsson, Baldur Bragi; Smárason, Sigurður Vidir; Garcia-Larsen, Vanessa; Gögele, Martin; Caprioli, Giulia; Bozzolan, Ilaria; Pramstaller, Peter P.; Rainer, Johannes (2022-03)
    Metabolomics in human serum samples provide a snapshot of the current metabolic state of an individuum. Metabolite concentrations are influenced by both genetic and environmental factors. Concentrations of certain metabolites can further depend on age, ...
  • Li, Yuchen; Sjölander, Arvid; Song, Huan; Cnattingius, Sven; Fang, Fang; Yang, Qian; Fernández de la Cruz, Lorena; Mataix-Cols, David; Brander, Gustaf; Li, Jiong; Zhang, Wei; Fall, Katja; D’Onofrio, Brian M.; Almqvist, Catarina; Lichtenstein, Paul; Valdimarsdóttir, Unnur Anna; Lu, Donghao (2022-01-01)
    Little is known about the contribution of pregnancy-related parental and perinatal factors to the development of stress-related disorders. We aimed to investigate whether parental/perinatal adversities entail higher risks of stress-related disorders ...
  • Isberg, Olof Gerdur; Giunchiglia, Valentina; McKenzie, James S.; Takats, Zoltan; Jonasson, Jon Gunnlaugur; Bodvarsdottir, Sigridur Klara; Thorsteinsdottir, Margret; Xiang, Yuchen (2022-05)
    Optical microscopy has long been the gold standard to analyse tissue samples for the diagnostics of various diseases, such as cancer. The current diagnostic workflow is time-consuming and labour-intensive, and manual annotation by a qualified pathologist ...
  • Kamen, Yasmine; Káradóttir, Ragnhildur Þóra (2021-06-18)
    Single-cell electrophysiological recordings combined with dye loading and immunohistochemistry provide unparalleled single-cell resolution of cell physiology, morphology, location, and protein expression. When correlated with bulk RNA sequencing, these ...
  • Guðbrandsson, Jóhannes; Franzdottir, Sigridur Rut; Kristjansson, Bjarni K.; Pashay Ahi, Ehsan; Maier, Valerie H.; Kapralova, Kalina; Snorrason, Sigurður S.; Jónsson, Zophonías Oddur; Palsson, Arnar (PeerJ, 2018-02-07)
    Phenotypic differences between closely related taxa or populations can arise through genetic variation or be environmentally induced, leading to altered transcription of genes during development. Comparative developmental studies of closely related ...
  • Kapralova, Kalina; Guðbrandsson, Jóhannes; Reynisdottir, Sigrun; Santos, Cristina B.; Baltanás, Vanessa C; Maier, Valerie H. untranslated; Snorrason, Sigurður S.; Palsson, Arnar (Public Library of Science (PLoS), 2013-07-24)
    Northern freshwater fish may be suitable for the genetic dissection of ecological traits because they invaded new habitats after the last ice age (∼10.000 years ago). Arctic charr (Salvelinus alpinus) colonizing streams and lakes in Iceland gave rise ...
  • Agnarsdóttir, Dagbjört; Sigurjónsdóttir, Vaka Kristín; Emilsdóttir, Arna Rut; Petersen, Erna; Sigfússon, Gunnlaugur; Rögnvaldsson, Ingólfur; Franzson, Leifur; Vernon, Hilary; Bjornsson, Hans Tomas (2022-07)
    Background: Cardiomyopathy is a known complication of organic acidemias but generally thought to be secondary to poor metabolic control. Methods: Our patient was found through biochemical testing and Sanger sequencing to harbor an Icelandic founder ...
  • Katrínardóttir, Borgný; Alves, Jose; Sigurjónsdóttir, Hrefna; Hersteinsson, Páll; Gunnarsson, Tomas Gretar (Public Library of Science (PLoS), 2015-07-10)
    Distinct preference of species for habitats is most often driven by long term differences in demographic rates between habitats. Estimating variation in those rates is key for developing successful conservation strategies. Stochastic events can interact ...
  • Stefánsson, Bjarki; Sandholt, Gunnar Birgir; Guðmundsdóttir, Ágústa (Elsevier BV, 2017-01)
    Trypsins from Atlantic cod (Gadus morhua), consisting of several isoenzymes, are highly active cold-adapted serine proteases. These trypsins are isolated for biomedical use in an eco-friendly manner from underutilized seafood by-products. Our group has ...
  • Sammar, Marei; Drobnjak, Tijana; Mandala, Maurizio; Gizurarson, Sveinbjörn; Huppertz, Berthold; Meiri, Hamutal (2019-07-01)
    Galectins regulate cell growth, proliferation, differentiation, apoptosis, signal transduction, mRNA splicing, and interactions with the extracellular matrix. Here we focus on the galectins in the reproductive system, particularly on a group of six ...
  • Ahluwalia, Tarunveer S.; Prins, Bram P.; Abdollahi, Mohammadreza; Armstrong, Nicola J.; Aslibekyan, Stella; Bain, Lisa; Jefferis, Barbara; Baumert, Jens; Beekman, Marian; Ben-Shlomo, Yoav; Bis, Joshua C.; Mitchell, Braxton D.; De Geus, Eco; Delgado, Graciela E.; Marek, Diana; Eriksson, Joel; Kajantie, Eero; Kanoni, Stavroula; Kemp, John P.; Lu, Chen; Marioni, Riccardo E.; McLachlan, Stela; Milaneschi, Yuri; Nolte, Ilja M.; Petrelis, Alexandros M.; Porcu, Eleonora; Sabater-Lleal, Maria; Naderi, Elnaz; Seppälä, Ilkka; Shah, Tina; Singhal, Gaurav; Standl, Marie; Teumer, Alexander; Thalamuthu, Anbupalam; Thiering, Elisabeth; Trompet, Stella; Ballantyne, Christie M.; Benjamin, Emelia J.; Casas, Juan P.; Toben, Catherine; Dedoussis, George; Deelen, Joris; Durda, Peter; Engmann, Jorgen; Feitosa, Mary F.; Grallert, Harald; Hammarstedt, Ann; Harris, Sarah E.; Homuth, Georg; Guðnason, Vilmundur G. (2021-01-30)
    Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease ...
  • Pei, Jiayi; Harakalova, Magdalena; Treibel, Thomas A.; Lumbers, R. Thomas; Boukens, Bastiaan J.; Efimov, Igor R.; Van Dinter, Jip T.; González, Arantxa; López, Begoña; El Azzouzi, Hamid; Van Den Dungen, Noortje; Van Dijk, Christian G.M.; Krebber, Merle M.; Den Ruijter, Hester M.; Pasterkamp, Gerard; Duncker, Dirk J.; Nieuwenhuis, Edward E.S.; De Weger, Roel; Huibers, Manon M.; Vink, Aryan; Moore, Jason H.; Moon, James C.; Verhaar, Marianne C.; Kararigas, Georgios; Mokry, Michal; Asselbergs, Folkert W.; Cheng, Caroline (2020-07-14)
    Background: H3K27ac histone acetylome changes contribute to the phenotypic response in heart diseases, particularly in end-stage heart failure. However, such epigenetic alterations have not been systematically investigated in remodeled non-failing human ...
  • Luperchio, Teresa Romeo; Applegate, Carolyn D.; Bodamer, Olaf; Björnsson, Hans Tómas (2020-02-01)
  • Ingthorsson, Saevar; Andersen, K; Hilmarsdóttir, Bylgja; Mælandsmo, Gunhild M; Magnusson, Magnus Karl; Gudjonsson, Thorarinn (Springer Nature, 2015-12-21)
    The members of the epidermal growth factor receptor (EGFR) kinase family are important players in breast morphogenesis and cancer. EGFR2/HER2 and EGFR expression have a prognostic value in certain subtypes of breast cancer such as HER2-amplified, ...
  • Beblo-Vranesevic, Kristina; Bohmeier, Maria; Schleumer, Sven; Rabbow, Elke; Perras, Alexandra K.; Moissl-Eichinger, Christine; Schwendner, Petra; Cockell, Charles S.; Vannier, Pauline; Marteinsson, Viggo T.; Monaghan, Euan P.; Riedo, Andreas; Ehrenfreund, Pascale; Garcia-Descalzo, Laura; Gómez, Felipe; Malki, Moustafa; Amils, Ricardo; Gaboyer, Frédéric; Hickman-Lewis, Keyron; Westall, Frances; Cabezas, Patricia; Walter, Nicolas; Rettberg, Petra (2020)
    Five bacterial (facultatively) anaerobic strains, namely Buttiauxella sp. MASE-IM-9, Clostridium sp. MASE-IM-4, Halanaerobium sp. MASE-BB-1, Trichococcus sp. MASE-IM-5, and Yersinia intermedia MASE-LG-1 isolated from different extreme natural environments ...
  • Gargallo-Garriga, Albert; Ayala-Roque, Marta; Sardans, Jordi; Bartrons, Mireia; Granda, Victor; Sigurdsson, Bjarni D.; Leblans, Niki; Oravec, Michal; Urban, Otmar; Janssens, Ivan; Penuelas, Josep (MDPI AG, 2017-08-23)
    Climate change is stronger at high than at temperate and tropical latitudes. The natural geothermal conditions in southern Iceland provide an opportunity to study the impact of warming on plants, because of the geothermal bedrock channels that induce ...
  • Hetzke, Thilo; Vogel, Marc; Gophane, Dnyaneshwar B.; Weigand, Julia E.; Suess, Beatrix; Sigurdsson, Snorri; Prisner, Thomas F. (Cold Spring Harbor Laboratory, 2018-10-18)
    The tetracycline-binding RNA aptamer (TC-aptamer) is a synthetic riboswitch that binds the antibiotic tetracycline (TC) with exceptionally high affinity. Although a crystal structure exists of the TC-bound state, little is known about the conformational ...
  • Zhang, Li; Pilarowski, Genay; Pich, Emilio Merlo; Nakatani, Atsushi; Dunlop, John; Baba, Rina; Matsuda, Satoru; Daini, Masaki; Hattori, Yasushi; Matsumoto, Shigemitsu; Ito, Mitsuhiro; Kimura, Haruhide; Björnsson, Hans Tómas (2021-03-12)
    Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D ( KMT2D), which normally adds methyl marks to lysine 4 on histone 3. Previous studies have shown that ...
  • Zimta, Alina-Andreea; Sigurjonsson, Olafur Eysteinn; Gulei, Diana; Tomuleasa, Ciprian (MDPI AG, 2020-08-15)
    Nowadays, advancements in the oncology sector regarding diagnosis methods allow us to specifically detect an increased number of cancer patients, some of them in incipient stages. However, one of the main issues consists of the invasive character of ...