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Browsing by Subject "Breast cancer"

Browsing by Subject "Breast cancer"

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  • Arason, Adalgeir; Agnarsson, Bjarni A.; Jóhannesdóttir, Gudrún; Jóhannsson, Óskar Th; Hilmarsdóttir, Bylgja; Reynisdóttir, Inga; Barkardottir, Rosa Bjork (MDPI AG, 2019-11-01)
    Mutations in BRCA1 result in predisposal to breast and ovarian cancers, but many variants exist with unknown clinical significance (VUS). One is BRCA1 c.4096+3A>G, which affects production of the full-length BRCA1 transcript, while augmenting transcripts ...
  • Þorvaldsdóttir, Birna (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-11)
    Germline mutations in BRCA2 increase the risk of breast and ovarian cancer. The BRCA2 protein is involved in maintaining genomic stability through its roles in DNA double strand break repair and protection of stalled replication forks. The BRCA2 gene ...
  • Ísberg, Ólöf Gerður; Kim, Jiyoung; Fridriksdottir, Agla; Morsing, Mikkel; Timmermans-Wielenga, Vera; Rønnov-Jessen, Lone; Petersen, Ole W.; Villadsen, René (Springer Science and Business Media LLC, 2019-10-16)
    Human breast cancer is believed to arise in luminal progenitors within the normal breast. A subset of these are double positive (DP) for basal and luminal keratins and localizes to a putative stem cell zone within ducts. We here present a new protocol ...
  • Smid, Marcel; Wilting, Saskia M.; Uhr, Katharina; Rodríguez-González, F. Germán; de Weerd, Vanja; Prager-Van der Smissen, Wendy J.C.; van der Vlugt-Daane, Michelle; van Galen, Anne; Nik-Zainal, Serena; Butler, Adam; Martin, Sancha; Davies, Helen R.; Staaf, Johan; van de Vijver, Marc J.; Richardson, Andrea L.; MacGrogan, Gaëten; Salgado, Roberto; van den Eynden, Gert G.G.M.; Purdie, Colin A.; Thompson, Alastair M.; Caldas, Carlos; Span, Paul N.; Sweep, Fred C.G.J.; Simpson, Peter T.; Lakhani, Sunil R.; Van Laere, Steven; Desmedt, Christine; Paradiso, Angelo; Eyfjord, Jorunn; Broeks, Annegien; Vincent-Salomon, Anne; Futreal, Andrew P.; Knappskog, Stian; King, Tari; Viari, Alain; Børresen-Dale, Anne-Lise; Stunnenberg, Hendrik G.; Stratton, Mike; Foekens, John A.; Sieuwerts, Anieta M.; Martens, John W.M. (Cold Spring Harbor Laboratory, 2019-01-28)
    Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs that does not rely on unmapped ...
  • Haraldsdottir, Alfheidur; Torfadottir, Johanna; Valdimarsdottir, Unnur; Adami, Hans-Olov; Aspelund, Thor; Tryggvadottir, Laufey; Þórðardóttir, Maríanna; Birgisdottir, Bryndis Eva; Harris, Tamara B.; Launer, Lenore J.; Gudnason, Vilmundur; Steingrimsdottir, Laufey (Public Library of Science (PLoS), 2018-05-30)
    Recent studies indicate that lifestyle factors in early life affect breast cancer risk. We therefore explored the association of high consumption of meat, milk, and whole grain products in adolescence and midlife, on breast cancer risk. We used data ...
  • Kristbjornsdottir, Adalbjorg (University of Iceland, School of Health Sciences, Faculty of Medicine, 2016-12)
    Background and aims: Previous studies in geothermal and volcanic areas have shown high risk of certain types of cancers. The aim was to study the association between residence in geothermal areas and the incidence and mortality of cancer in ...
  • Steinhaeuser, Sarah Sophie (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-08)
    The microenvironment is increasingly being recognized as a key player in supporting cancer progression. Therefore, investigating heterotypic interactions between cancer cells and their microenvironment is important for improving our understanding ...
  • Halldorsson, Skarphedinn; Rohatgi, Neha; Magnúsdóttir, Manuela; Choudhary, Kumari Sonal; Gudjonsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdóttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild M.; Guðmundsson, Steinn; Rolfsson, Óttar (Elsevier BV, 2017-06)
    Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
  • Shen, Qing; Jöud, Anna; Schelin, Maria E. C.; Sjölander, Arvid; Cao, Yang; Sparén, Pär; Fall, Katja; Czene, Kamila; Valdimarsdottir, Unnur; Fang, Fang (Springer Science and Business Media LLC, 2019-12-10)
    Background: An increasing number of women are evaluated for potential breast cancer and may experience mental distress during evaluation. We aim to assess the risks of psychiatric disorders and cardiovascular diseases during the diagnostic workup of ...
  • Interrante, Mary K.; Segal, Hannah; Peshkin, Beth N.; Valdimarsdottir, Heiddis; Nusbaum, Rachel; Similuk, Morgan; DeMarco, Tiffani; Hooker, Gillian; Graves, Kristi; Isaacs, Claudine; Wood, Marie; McKinnon, Wendy; Garber, Judy; McCormick, Shelley; Heinzmann, Jessica; Kinney, Anita Y.; Schwartz, Marc D. (Oxford University Press (OUP), 2017-09-01)
    Background: Telephone delivery of genetic counseling is an alternative to in-person genetic counseling because it may extend the reach of genetic counseling. Previous reports have established the noninferiority of telephone counseling on short-term ...
  • Rafnar, Thorunn; Bjarni Gunnarsson; Ólafur A. Stefánsson; Sulem, Patrick; Ingason, Andrés; Frigge, Michael L.; Lilja Stefánsdóttir; Jón K. Sigurðsson; Tragante, Vinicius; Steinthorsdottir, Valgerdur; Styrkarsdottir, Unnur; Stacey, Simon N.; Gudmundsson, Julius; Arnadottir, Gudny; Oddsson, Asmundur; Zink, Florian; Halldorsson, Gisli; Sveinbjornsson, Gardar; Kristjansson, Ragnar; Ólafur B. Davíðsson; Anna Þórhildur Salvarsdóttir; Ásgeir Thoroddsen; Elísabet A. Helgadottir; Katrín Kristjánsdóttir; Orri Ingþórsson; Valur Guðmundsson; Geirsson, Reynir T.; Ragnheiður Árnadottir; Gudbjartsson, Daniel; Masson, Gisli; Asselbergs, Folkert W.; Jón Gunnlaugur Jónasson; Karl Ólafsson; Thorsteinsdottir, Unnur; Halldórsson, Bjarni; Thorleifsson, Gudmar; Stefansson, Kari (Springer Science and Business Media LLC, 2018-09-07)
    Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of leiomyoma in European women (16,595 cases and 523,330 controls), uncovering 21 variants at 16 loci that associate with ...