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Now showing items 2254-2273 of 2983
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(Elsevier BV, 2020-11-01)Last years, more than 46 unique biosimilars were approved by EMA and/or US-FDA following patent expiration of reference products. Biosimilars are not identical like generics, but highly similar versions where demonstrating biosimilarity of quality ... -
(Springer Science and Business Media LLC, 2020-06-03)High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications ...
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(Association for Research in Vision and Ophthalmology (ARVO), 2019-08-01)Objects have a variety of different features that can be represented as probability distributions. Recent findings show that in addition to mean and variance, the visual system can also encode the shape of feature distributions for features like color ...
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(Springer Nature, 2017-06-13)The persistence of common, heritable psychiatric disorders that reduce reproductive fitness is an evolutionary paradox. Here, we investigate the selection pressures on sequence variants that predispose to schizophrenia, autism, bipolar disorder, major ...
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(Wiley, 2020-08)Background Childhood Social Anxiety Disorder (SAD) is common and impairing. The recommended treatment is a disorder specific form of cognitive behavioural therapy (CBT) that includes social skills training and, whilst they appear to be more effective ...
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(Elsevier BV, 2019-11)Background: Menopause is associated with a number of adverse health effects and its timing has been reported to be influenced by several lifestyle factors. Whether greenspace exposure is associated with age at menopause has not yet been investigated. ...
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(American Physical Society (APS), 2018-06-12)Recently, it was shown both theoretically and experimentally that certain three-dimensional (3D) materials have Dirac points in the Brillouin zone, thus being 3D analogs of graphene. Moreover, it was suggested that under specific conditions a pair of ...
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(IOP Publishing, 2018-05-31)We study the structure of the elementary excitations and their propagation in chiral hybrid structure, comprising an array of two-level systems (TLSs) coupled to a one-dimensional photonic waveguide. The chirality is achieved via spin-locking effect, ...
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(BMJ, 2017-08)Introduction Sleep length has been associated with obesity and various adverse health outcomes. The possible association of sleep length and respiratory symptoms has not been previously described. The aim of this study was to investigate the association ...
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(Public Library of Science (PLoS), 2017-10-25)The limits of life of aerobic microorganisms are well understood, but the responses of anaerobic microorganisms to individual and combined extreme stressors are less well known. Motivated by an interest in understanding the survivability of anaerobic ...
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(Springer Nature, 2017-08-15)Background There are an increasing number of studies regarding genetic manipulation of cyanobacteria to produce commercially interesting compounds. The majority of these works study the expression and optimization of a selected heterologous pathway, ...
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(University of Sydney, Faculty of Architecture, Design & Planning, 2013)The urban population around the world is growing rapidly. Although increasing urbanization has positive aspects, it has also raised concerns about environmental, economic and social sustainability. As response, some design and planning solutions ...
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(University of Iceland, School of Engineering and Natural Sciences, Faculty of Physical Sciences, 2024-10)The thesis contains material from papers studying polynomial approximations of holomorphic functions in several variables. These approximations are weighted, in the sense that the norm used to assess the approximation is weighted, and polynomials used ...
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(University of Iceland, School of Engineering and Natural Sciences, Faculty of Life and Environmental Sciences, 2024-05)Í þessari ritgerð er fjallað um stafræna nýsköpun og áskoranir fyrir endurhugsun ferðaþjónustunnar með áherslu á lífsstílsfrumkvöðla í dreifbýli. Útgangspunktur rannsóknarinnar er umræða um þróun ferðaþjónustu sem ávarpar þörf fyrir að draga úr neikvæðum ...
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(DePaul University, 2024)As is well known, Plato was a significant influence on Gadamer’s thought. Nevertheless, Gadamer’s interpretation of Plato changed through the years, and he became increasing sympathetic towards Plato in his later works after 1960’s Truth and Method. ...
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(University of Iceland, School of Health Sciences, Faculty of Nursing, 2017-06)Purpose: Continuous peripheral pulse oximetry for monitoring adequacy of oxygenation is probably the most important technological advance for patients’ monitoring and safety in the last decades. Pulse oximetry has the disadvantage of measuring the ...
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(Public Library of Science (PLoS), 2017-03-22)Background Determination of the blood oxyhemoglobin saturation in the retinal vessels of the eye can be achieved through spectrophotometric retinal oximetry which provides access to the state of oxyhemoglobin saturation in the central nervous system ...
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(Public Library of Science (PLoS), 2016-02-03)Dual wavelength retinal oximetry has been developed for adults, but is not available for infants. Retinal oximetry may provide insight into the pathophysiology of oxygen-mediated diseases like retinopathy of prematurity. More insight in the oxygen ...
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(Elsevier BV, 2018)Introduction We have previously reported that retinal vessel oxygen saturation is increased in mild-to-moderate dementia of Alzheimer's type when compared with healthy individuals. Mild cognitive impairment (MCI) is the predementia stage of the disease. ...
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(Springer Science and Business Media LLC, 2020-09-21)The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer ...
Now showing items 2254-2273 of 2983