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Retinal oxygen metabolism in patients with mild cognitive impairment
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| Titill: | Retinal oxygen metabolism in patients with mild cognitive impairment |
| Höfundur: |
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| Útgáfa: | 2018 |
| Tungumál: | Enska |
| Umfang: | 340-345 |
| Háskóli/Stofnun: | Háskóli Íslands University of Iceland |
| Svið: | Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) |
| Deild: | Læknadeild (HÍ) Faculty of Medicine (UI) |
| Birtist í: | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring; |
| ISSN: | 2352-8729 |
| DOI: | 10.1016/j.dadm.2018.03.002 |
| Efnisorð: | Mild cognitive impairment; Alzheimer's disease; Oximetry; Retina; Retinal vessels; Oxygen saturation; Spectrophotometry; Alzheimer sjúkdómur; Sjónhimna; Heilabilun |
| URI: | https://hdl.handle.net/20.500.11815/1104 |
Tilvitnun:Olafsdottir, O. B., Saevarsdottir, H. S., Hardarson, S. H., Hannesdottir, K. H., Traustadottir, V. D., Karlsson, R. A., . . . Snaedal, J. (2018). Retinal oxygen metabolism in patients with mild cognitive impairment. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 340-345. doi:https://doi.org/10.1016/j.dadm.2018.03.002
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Útdráttur:Introduction
We have previously reported that retinal vessel oxygen saturation is increased in mild-to-moderate dementia of Alzheimer's type when compared with healthy individuals. Mild cognitive impairment (MCI) is the predementia stage of the disease. The main purpose was to investigate if these changes are seen in MCI.
Methods
Retinal vessel oxygen saturation was measured in 42 patients with MCI and 42 healthy individuals with a noninvasive retinal oximeter, Oxymap T1. The groups were paired according to age.
Results
Arteriolar and venular oxygen saturation was increased in MCI patients compared to healthy individuals (arterioles: 93.1 ± 3.7% vs. 91.1 ± 3.4%, P = .01; venules: 59.6 ± 6.1% vs. 54.9 ± 6.4%, P = .001). Arteriovenous difference was decreased in MCI compared to healthy individuals (33.5 ± 4.5% vs. 36.2 ± 5.2%, P = .01).
Discussion
Increased retinal vessel oxygen saturation and decreased arteriovenous difference in MCI could reflect less oxygen extraction by retinal tissue. This indicates that retinal oxygen metabolism may be affected in patients with MCI.
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Athugasemdir:Publisher's version (útgefin grein)
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Leyfi:This is an open access article under the CC BY-NC-ND
license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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