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Living with Technology. Data work and smartwatch data trends for patients with serious mental illnesses
(2025-01) Sigurdardóttir, Steinunn Gróa; Ingimarsson, Oddur; Islind, Anna Sigridur; Department of Computer Science
As healthcare is being reshaped by technology, researchers are increasingly relying on patients to generate data. However, the efforts patients dedicate to data collection for research and treatment purposes are seldom scrutinised. We examine the data work of 21 patients diagnosed with schizophrenia or bipolar disorder who participated in our digital mental health intervention, equipped with a smartwatch and a mobile application. We offer in-depth insights into their somatic experiences while living with technology over time by analysing the impact of data work when living with technology. Our paper offers insights into the data work of patients, highlighting its importance as a valuable resource for future digital mental health interventions. We outline what living with technology for individuals with serious mental illnesses entails by unravelling their data work into five themes. Moreover, we provide a model that others can use when incorporating somatic IS artifacts into practice.
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Comparative efficacy and acceptability of pharmacological, psychological, and neurostimulatory interventions for ADHD in adults : a systematic review and component network meta-analysis
(2025-01) Ostinelli, Edoardo G.; Schulze, Marcel; Zangani, Caroline; Farhat, Luis C.; Tomlinson, Anneka; Del Giovane, Cinzia; Chamberlain, Samuel R.; Philipsen, Alexandra; Young, Susan; Cowen, Phil J.; Bilbow, Andrea; Cipriani, Andrea; Cortese, Samuele
Background: The comparative benefits and harms of available interventions for ADHD in adults remain unclear. We aimed to address these important knowledge gaps. Methods: In this systematic review and component network meta-analysis (NMA), we searched multiple databases for published and unpublished randomised controlled trials (RCTs) investigating pharmacological and non-pharmacological interventions for ADHD in adults from database inception to Sept 6, 2023. We included aggregate data from RCTs comparing interventions against controls or any other eligible active intervention for the treatment of symptoms in adults (ages ≥18 years) with a formal diagnosis of ADHD. Pharmacological therapies were included only if their maximum planned doses were considered eligible according to international guidelines. We included RCTs of at least 1-week duration for medications, of at least four sessions for psychological therapies, and of any length deemed appropriate for neurostimulation. For RCTs of medications, cognitive training, or neurostimulation alone, we included only double-blind RCTs. At least two authors independently screened the identified records and extracted data from eligible RCTs. Our primary outcomes were efficacy (change in ADHD core symptom severity on self-rated and clinician-rated scales at timepoints closest to 12 weeks) and acceptability (all-cause discontinuation). We estimated standardised mean differences (SMDs) and odds ratios (ORs) using random effects pairwise and component NMA, dismantling interventions into specific therapeutic components. This study was registered with PROSPERO (CRD42021265576). People with relevant lived experience were involved in the conduct of the research and writing process. Findings: Of 32 416 records, 113 unique RCTs encompassing 14 887 participants were eligible for analysis (6787 [45·6%] females, 7638 [51·3%] males, 462 [3·1%] sex not reported). The RCTs encompassed pharmacological therapies (63 [55·8%] of 113 RCTs; 6875 participants), psychological therapies (28 [24·8%] of 113 RCTs; 1116 participants), neurostimulatory therapy and neurofeedback (ten [8·8%] of 113 RCTs; 194 participants), and control conditions (97 [85·8%] of 113 RCTs; 5770 participants). For reduction of ADHD core symptoms at 12 weeks on both self-reported and clinician-reported rating scales, atomoxetine (self-reported scale SMD –0·38, 95% CI –0·56 to –0·21; clinician-reported scale –0·51, –0·64 to –0·37) and stimulants (0·39, –0·52 to –0·26; –0·61, –0·71 to –0·51) had higher efficacy than placebo (Confidence in Network Meta-Analysis [CINeMA] ranging between very low and moderate). Cognitive behavioural therapy (–0·76, –1·26 to –0·26), cognitive remediation (–1·35, –2·42 to –0·27), mindfulness (–0·79, –1·29 to –0·29), psychoeducation (–0·77, –1·35 to –0·18), and transcranial direct current stimulation (–0·78; –1·13 to –0·43) were better than placebo only on clinician-reported measures. Regarding acceptability, all therapeutic components were similar to placebo other than atomoxetine (OR 1·43, 95% CI 1·14 to 1·80; CINeMA moderate) and guanfacine (3·70, 1·22 to 11·19; high), which had lower acceptability compared with placebo. Baseline severity of self-reported ADHD core symptoms, year of publication, percentage of male individuals, and percentage of individuals with ADHD and another mental health condition did not explain the heterogeneity observed in unadjusted non-component models of self-reported ADHD core symptoms. Treatment length had little effect on heterogeneity. Interpretation: Stimulants and atomoxetine were the only interventions with evidence of beneficial effects in terms of reducing ADHD core symptoms in the short term, supported by both self-reported and clinician-reported ratings. However, atomoxetine was less acceptable than placebo. Medications for ADHD were not efficacious on additional relevant outcomes, such as quality of life, and evidence in the longer term is underinvestigated. The effects of non-pharmacological strategies were inconsistent across different raters. Our network meta-analysis represents the most comprehensive synthesis of available evidence to inform future guidelines in the field. Funding: UK National Institute for Health and Care Research.
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ColMA-based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells
(2025-01) Cortella, Giacomo; Lamparelli, Erwin Pavel; Ciardulli, Maria Camilla; Lovecchio, Joseph; Giordano, Emanuele; Maffulli, Nicola; Della Porta, Giovanna
The advent of bioprinting has enabled the creation of precise three-dimensional (3D) cell cultures suitable for biomimetic in vitro models. In this study, we developed a novel protocol for 3D printing methacrylated collagen (ColMa, or PhotoCol®) combined with tendon stem/progenitor cells (hTSPCs) derived from human tendon explants. Although pure ColMa has not previously been proposed as a printable hydrogel, this paper outlines a robust and highly reproducible pipeline for bioprinting this material. Indeed, we successfully fabricated a 3D bioengineered scaffold and cultured it for 21 days under perfusion conditions with medium supplemented with growth/differentiation factor-5 (GDF-5). This bioprinting pipeline and the culture conditions created an exceptionally favorable 3D environment, enabling the cells to proliferate, exhibit tenogenic behaviors, and produce a new collagen type I matrix, thereby remodeling the surrounding environment. Indeed, over the 21-day culture period under perfusion condition, tenomodulin expression showed a significant upregulation on day 7, with a 2.3-fold increase, compared to days 14 and 21. Collagen type I gene expression was upregulated nearly 10-fold by day 14. This trend was further confirmed by western blot analysis, which revealed a statistically significant difference in tenomodulin expression between day 21 and both day 7 and day 14. For type I collagen, significant differences were observed between day 0 and day 21, as well as between day 0 and day 14, with a p-value of 0.01. These results indicate a progressive over-expression of type I collagen, reflecting cell differentiation towards a proper tenogenic phenotype. Cytokines, such as IL-8 and IL-6, levels peaked at 8566 and 7636 pg/mL, respectively, on day 7, before decreasing to 54 and 46 pg/mL by day 21. Overall, the data suggest that the novel ColMa bioprinting protocol effectively provided a conducive environment for the growth and proper differentiation of hTSPCs, showcasing its potential for studying cell behavior and tenogenic differentiation.
Verk
Renewable bites : How energy sources shape food healthiness judgments
(2025) Folwarczny, Michał; Gasiorowska, Agata; Sigurdsson, Valdimar; Otterbring, Tobias; Department of Business and Economics
Public opinion increasingly associates nuclear energy with negative environmental outcomes, but can this perception influence how people judge food? This study examines whether the perceived naturalness of energy sources used to manufacture kitchen appliances affects the perceived healthiness of foods prepared with those appliances. Food prepared with appliances manufactured using nuclear energy was consistently perceived as less healthy than food prepared with appliances manufactured without any specified energy source (Studies 1–3; Ntotal = 1,939), with this negative nuclear effect also emerging when compared against a wind energy condition in the most well-powered, preregistered experiment (Study 3). Further, the effect of nuclear energy on healthiness perceptions was indirect through perceived risk (Study 3), implying that nuclear energy evoked greater perceived risk, which ultimately reduced perceived healthiness. This work extends contagion theory by showing that perceptions of unnaturalness can spread through abstract and distant links—such as energy sources used in manufacturing— to shape judgments in unrelated domains. The persistence of negative contagion effects associated with nuclear energy, but the more modest positive effects from wind energy, aligns with the principle of negativity dominance in contagion research. These results suggest that consumer resistance to nuclear energy may stem, in part, from naturalness perceptions.
Verk
Opportunities and Challenges for Designing in Connected Health : Insights From an Expert Workshop
(2025) Premanandan, Shweta; Ahmad, Awais; Jaranka, Alex; Üreten, Ece; Lee, Eunji; Gross, Jennifer; Cajander, Åsa; Ouhbi, Sofia; Lárusdóttir, Marta; Eriksson, Owen; Öhlund, Sten Erik; Department of Computer Science
Health care increasingly depends on information and communication technology. This offers both opportunities and challenges when designing connected health systems. While individual studies examined particular cases, there is a limited synthesis of insights across projects. The objective of this paper is to explore these opportunities and challenges by examining 6 diverse connected health projects and synthesizing lessons from an expert workshop. To achieve this, we conducted a full-day workshop that brought together 6 connected health projects. The workshop used an iterative and participatory process which included paper submissions and presentations and facilitated discussions, and a gallery walk to enable cross-case comparison and collaborative reflection. Thematic analysis of workshop outputs was then used to synthesize key opportunities and challenges in designing connected health systems. The 6 projects represented a variety of design methods and approaches to connected health, and their discussion surfaced both opportunities and challenges in this domain. Key opportunities include improving data integration and usability, enhancing collaboration across stakeholders, using a user-centered and iterative design process, addressing complexity in sociotechnical systems, sustainability, and adopting digital infrastructures for seamless communication. Participants also identified important challenges, namely exchange of information, interoperability, and communication; ethical considerations, rules, and regulations; understanding design, evaluation, and standards; actionable data, reliability, quality, and trust in data; and stakeholder involvement. The contribution of this paper lies in the synthesis of insights across multiple projects and perspectives to provide practical guidance for researchers, designers, and policymakers. By highlighting opportunities and challenges in designing connected health systems, the findings emphasize the importance of patient-centered, sustainable, and collaborative design approaches while also pointing to the need to address persistent barriers. Advancing connected health will require adopting iterative and inclusive design processes that prioritize patient-centeredness, sustainability, and collaboration across health care systems.

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