bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

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dc.contributorHáskóli Íslandsen_US
dc.contributorUniversity of Icelanden_US
dc.contributor.authorJagtap, Anil P.
dc.contributor.authorGeiger, Michel-Andreas
dc.contributor.authorStöppler, Daniel
dc.contributor.authorOrwick-Rydmark, Marcella
dc.contributor.authorOschkinat, Hartmut
dc.contributor.authorSigurdsson, Snorri
dc.contributor.departmentRaunvísindadeild (HÍ)en_US
dc.contributor.departmentFaculty of Physical Sciences (UI)en_US
dc.contributor.departmentRaunvísindastofnun (HÍ)en_US
dc.contributor.departmentScience Institute (UI)en_US
dc.contributor.schoolVerkfræði- og náttúruvísindasvið (HÍ)en_US
dc.contributor.schoolSchool of Engineering and Natural Sciences (UI)en_US
dc.date.accessioned2020-08-10T15:20:15Z
dc.date.available2020-08-10T15:20:15Z
dc.date.issued2016
dc.descriptionPost-print (lokagerð höfundar)en_US
dc.description.abstractDynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (bcTol), designed for biological applications, that yielded an enhancement value of 244 in a microcrystalline SH3 domain sample at 110 K.en_US
dc.description.sponsorshipThis work was financially supported by the Icelandic Research Fund (141062051), the Deutsche Forschungsgemeinschaft (SFB 1078, 740 and 765) and by a doctoral fellowship to A. P. J. from the University of Icelandic Research Fund. We thank A. Diehl, K. Rehbein, N. Erdmann and D. Michl for the preparation of microcrystalline SH3 and channelrhodopsin samples, Dr S. Jonsdottir for assistance in collecting analytical data for structural characterization of the radicals, as well as P. Hegemann and K. Stehfest for helpful discussions concerning expression and purification of channelrhodopsin.en_US
dc.description.versionPeer revieweden_US
dc.format.extent7020-7023en_US
dc.identifier.citationJagtap, A. P., Geiger, M. -A., Stöppler, D., Orwick-Rydmark, M., Oschkinat, H., & Sigurdsson, S. T. (2016). BcTol: A highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules. Chemical Communications, 52(43), 7020-7023. doi:10.1039/c6cc01813ken_US
dc.identifier.doi10.1039/C6CC01813K
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X (eISSN)
dc.identifier.journalChemical Communicationsen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11815/1959
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistry (RSC)en_US
dc.relation.ispartofseriesChemical Communications;52(43)
dc.relation.urlhttp://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC01813Ken_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngle spinning NMRen_US
dc.subjectSolid stateen_US
dc.subjectNitroxide biradicalsen_US
dc.subjectMagnetic resonanceen_US
dc.subjectAmyloid fibrilsen_US
dc.subjectProteinen_US
dc.subjectResolutionen_US
dc.subjectSpectroscopyen_US
dc.subjectAgentsen_US
dc.subjectLitrófsgreiningen_US
dc.subjectSegulmagnen_US
dc.subjectPrótínen_US
dc.subjectKjarnsýruren_US
dc.titlebcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomoleculesen_US
dc.typeinfo:eu-repo/semantics/articleen_US

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