Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland

Almenn færsla
dc.contributor.authorNorddahl, Gudmundur L.
dc.contributor.authorMelsted, Páll
dc.contributor.authorGunnarsdottir, Kristbjorg
dc.contributor.authorHalldórsson, Gísli Hreinn
dc.contributor.authorOlafsdottir, Thorunn
dc.contributor.authorGylfason, Arnaldur
dc.contributor.authorKristjánsson, Már
dc.contributor.authorMagnusson, Olafur T.
dc.contributor.authorsulem, patrick
dc.contributor.authorGudbjartsson, Daniel Fannar
dc.contributor.authorÞorsteinsdóttir, Unnur
dc.contributor.authorJónsdóttir, Ingileif
dc.contributor.authorStefánsson, Kári
dc.contributor.departmentFaculty of Industrial Engineering, Mechanical Engineering and Computer Science
dc.contributor.departmentFaculty of Medicine
dc.contributor.schoolHealth Sciences
dc.date.accessioned2025-11-20T08:50:35Z
dc.date.available2025-11-20T08:50:35Z
dc.date.issued2022-09-28
dc.descriptionPublisher Copyright: © 2022, The Author(s).en
dc.description.abstractBy the end of July 2021, the majority of the Icelandic population had received vaccination against COVID-19. In mid-July a wave of SARS-CoV-2 infections, dominated by the Delta variant, spread through the population, followed by an Omicron wave in December. A booster vaccination campaign was initiated to curb the spread of the virus. We estimate the risk of infection for different vaccine combinations using vaccination data from 276,028 persons and 963,557 qPCR tests for 277,687 persons. We measure anti-Spike-RBD antibody levels and ACE2-Spike binding inhibitory activity in 371 persons who received one of four recommended vaccination schedules with or without an mRNA vaccine booster. Overall, we find different antibody levels and inhibitory activity in recommended vaccination schedules, reflected in the observed risk of SARS-CoV-2 infections. We observe an increased protection following mRNA boosters, against both Omicron and Delta variant infections, although BNT162b2 boosters provide greater protection against Omicron than mRNA-1273 boosters.en
dc.description.versionPeer revieweden
dc.format.extent2744365
dc.format.extent5701
dc.identifier.citationNorddahl, G L, Melsted, P, Gunnarsdottir, K, Halldórsson, G H, Olafsdottir, T, Gylfason, A, Kristjánsson, M, Magnusson, O T, sulem, P, Gudbjartsson, D F, Þorsteinsdóttir, U, Jónsdóttir, I & Stefánsson, K 2022, 'Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland', Nature Communications, vol. 13, no. 1, 5701, pp. 5701. https://doi.org/10.1038/s41467-022-33076-4en
dc.identifier.doi10.1038/s41467-022-33076-4
dc.identifier.issn2041-1723
dc.identifier.other61920753
dc.identifier.other84c48885-f0f1-4db1-910e-5fb29b574edf
dc.identifier.other85138919120
dc.identifier.other36171188
dc.identifier.otherunpaywall: 10.1038/s41467-022-33076-4
dc.identifier.urihttps://hdl.handle.net/20.500.11815/6798
dc.language.isoen
dc.relation.ispartofseriesNature Communications; 13(1)en
dc.relation.urlhttps://www.scopus.com/pages/publications/85138919120en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectAngiotensin-Converting Enzyme 2en
dc.subjectAntibodies, Viral/metabolismen
dc.subjectBNT162 Vaccineen
dc.subjectCOVID-19/epidemiologyen
dc.subjectHumansen
dc.subjectIceland/epidemiologyen
dc.subjectRNA, Messengeren
dc.subjectSARS-CoV-2/geneticsen
dc.subjectVaccinationen
dc.subjectVaccines, Syntheticen
dc.subjectViral Vaccinesen
dc.subjectmRNA Vaccinesen
dc.subjectMultidisciplinaryen
dc.subjectGeneral Physics and Astronomyen
dc.subjectGeneral Chemistryen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleEffect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Icelanden
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/articleen

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