A shared genetic contribution to breast cancer and schizophrenia

Almenn færsla
dc.contributorHáskóli Íslandsen_US
dc.contributorUniversity of Icelanden_US
dc.contributor.authorLu, Donghao
dc.contributor.authorSong, Jie
dc.contributor.authorLu, Yi
dc.contributor.authorFall, Katja
dc.contributor.authorChen, Xu
dc.contributor.authorFang, Fang
dc.contributor.authorLandén, Mikael
dc.contributor.authorHultman, Christina M.
dc.contributor.authorCzene, Kamila
dc.contributor.authorSullivan, Patrick
dc.contributor.authorTamimi, Rulla M.
dc.contributor.authorValdimarsdottir, Unnur
dc.contributor.departmentLæknadeild (HÍ)en_US
dc.contributor.departmentFaculty of Medicine (UI)en_US
dc.contributor.schoolHeilbrigðisvísindasvið (HÍ)en_US
dc.contributor.schoolSchool of Health Sciences (UI)en_US
dc.date.accessioned2020-10-22T10:46:45Z
dc.date.available2020-10-22T10:46:45Z
dc.date.issued2020-09-15
dc.descriptionPublisher's version (útgefin grein)en_US
dc.description.abstractAn association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophrenia with breast cancer and vice versa, based on a Swedish population-based cohort and GWAS data from international consortia. We observe a genetic correlation of 0.14 (95% CI 0.09–0.19) and identify a shared locus at 19p13 (GATAD2A) associated with risks of breast cancer and schizophrenia. The epidemiological bidirectional association between breast cancer and schizophrenia may partly be explained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms.en_US
dc.description.sponsorshipThis work is supported by the Swedish Research Council (grant number: 2018-00648, to D.L.), Karolinska Institutet Research Foundation (grant number: 2018-01585, to D.L.), Grant of Excellence, Icelandic Research Fund (grant number 163362-051, to U.A.V.), and ERC Consolidator Grant (StressGene, grant number:726413, to U.A.V.). We thank Dr. Agnar Helgason, Dr. Patrick Sulem, and Dr. Kári Stefánsson from deCODE Genetics, Iceland for helpful discussions on data analysis and interpretations. We also acknowledge the shared GWAS statistical summaries of schizophrenia from the Psychiatric Genetics Consortium and breast cancer from the Breast Cancer Association Consortium.en_US
dc.description.versionPeer Revieweden_US
dc.format.extent4637en_US
dc.identifier.citationLu, D., Song, J., Lu, Y. et al. A shared genetic contribution to breast cancer and schizophrenia. Nat Commun 11, 4637 (2020). https://doi.org/10.1038/s41467-020-18492-8en_US
dc.identifier.doi10.1038/s41467-020-18492-8
dc.identifier.issn2041-1723
dc.identifier.journalNature Communicationsen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11815/2131
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofseriesNature Communications;11(1)
dc.relation.urlhttps://www.nature.com/articles/s41467-020-18492-8en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectBreast canceren_US
dc.subjectPhenotypeen_US
dc.subjectGeðklofien_US
dc.subjectBrjóstakrabbameinen_US
dc.subjectArfgengien_US
dc.subjectErfðarannsókniren_US
dc.titleA shared genetic contribution to breast cancer and schizophreniaen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dcterms.licenseOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US

Skrár

Original bundle

Niðurstöður 1 - 1 af 1
Thumbnail Image
Nafn:
s41467-020-18492-8.pdf
Stærð:
1.03 MB
Snið:
Adobe Portable Document Format
Description:
Publisher´s version
Hlaða niður

Undirflokkur

Greinar- HÍ

Öll gögn í Opnum vísindum eru vernduð af ákvæðum höfundalaga og með öllum réttindum áskildum, nema annað sé tekið fram.