B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974?

dc.contributorHáskólinn í Reykjavíken_US
dc.contributorReykjavik Universityen_US
dc.contributor.authorDesmirean, Minodora
dc.contributor.authorRauch, Sebastian
dc.contributor.authorJurj, Ancuta
dc.contributor.authorPasca, Sergiu
dc.contributor.authorIluta, Sabina
dc.contributor.authorTeodorescu, Patric
dc.contributor.authorBerce, Cristian
dc.contributor.authorZimta, Alina-Andreea
dc.contributor.authorTurcas, Cristina
dc.contributor.authorTigu, Adrian-Bogdan
dc.contributor.authorMoldovan, Cristian
dc.contributor.authorParis, Irene
dc.contributor.authorSteinheber, Jakob
dc.contributor.authorRichlitzki, Cedric
dc.contributor.authorConstantinescu, Catalin
dc.contributor.authorSigurjonsson, Olafur
dc.contributor.authorDima, Delia
dc.contributor.authorPetrushev, Bobe
dc.contributor.authorTomuleasa, Ciprian
dc.contributor.departmentVerkfræðideild (HR)en_US
dc.contributor.departmentDepartment of Engineering (RU)en_US
dc.contributor.schoolTæknisvið (HR)en_US
dc.contributor.schoolSchool of Technology (RU)en_US
dc.date.accessioned2021-03-24T15:56:05Z
dc.date.available2021-03-24T15:56:05Z
dc.date.issued2020-10-24
dc.descriptionPublisher's version (útgefin grein)en_US
dc.description.abstractMalignant lymphomas are a heterogeneous group of malignancies that develop both in nodal and extranodal sites. The different tissues involved and the highly variable clinicopathological characteristics are linked to the association between the lymphoid neoplastic cells and the tissues they infiltrate. The immune system has developed mechanisms to protect the normal tissue from malignant growth. In this review, we aim to explain how T lymphocyte-driven control is linked to tumor development and describe the tumor-suppressive components of the resistant framework. This manuscript brings forward a new insight with regard to intercellular and intracellular signaling, the immune microenvironment, the impact of therapy, and its predictive implications. A better understanding of the key components of the lymphoma environment is important to properly assess the role of both B and T lymphocytes, as well as their interplay, just as two legendary boxers face each other in a heavyweight title final, as was the case of Ali versus Foreman.en_US
dc.description.sponsorshipThe research on the lymphoma microenvironment was funded by an internal grant of the Iuliu Hatieganu University, School of Doctoral Studies (PCD 2018-2021) (Minodora Desmirean), under the frame of European Social Found, Human Capital Operational Program 2014-2020, project no. POCU/380/6/13/125171 (Minodora Desmirean) and the Romanian Ministry of Research and Innovation, CCCDI-UEFISCDI, Project No. PN-III-P4-ID-PCCF-2016-0112 within PNCDI III, by an award for Young Research Teams 2020-2022 (Grant No. PN-III-P1-1.1-TE-2019-0271) (both Ciprian Tomuleasa) as well as by an international collaborative grant of the European Economic Space between Romania and Iceland 2020-2022 (Grant No. 19-COP-0031) (Ciprian Tomuleasa).en_US
dc.description.version"Peer Reviewed"en_US
dc.format.extent3412en_US
dc.identifier.citationDesmirean, M., Rauch, S., Jurj, A., Pasca, S., Iluta, S., Teodorescu, P., Berce, C., Zimta, A.-A., Turcas, C., Tigu, A.-B., Moldovan, C., Paris, I., Steinheber, J., Richlitzki, C., Constantinescu, C., Sigurjonsson, O. E., Dima, D., Petrushev, B., & Tomuleasa, C. (2020). B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974? Journal of Clinical Medicine, 9(11), 3412. https://doi.org/10.3390/jcm9113412en_US
dc.identifier.doi10.3390/jcm9113412
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/20.500.11815/2514
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesJournal of Clinical Medicine;9(11)
dc.relation.urlhttps://www.mdpi.com/2077-0383/9/11/3412/pdfen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMalignant lymphomasen_US
dc.subjectTumor microenvironmenten_US
dc.subjectLymphocyte inter-talken_US
dc.subjectB lymphocytesen_US
dc.subjectT-Lymphocytesen_US
dc.subjectEitilfrumukrabbameinen_US
dc.subjectEitlaren_US
dc.subjectÆxlien_US
dc.subjectFrumuren_US
dc.subjectT-frumuren_US
dc.subjectÓnæmisfræðien_US
dc.titleB Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974?en_US
dc.typeinfo:eu-repo/semantics/articleen_US
dcterms.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US

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