Cytotoxicity studies of water soluble coordination compounds with a [Mo 2 O 2 S 2 ] 2+ core

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dc.contributorHáskóli Íslandsen_US
dc.contributorUniversity of Icelanden_US
dc.contributor.authorGrétarsdóttir, Jóhanna M.
dc.contributor.authorBobersky, Sandra
dc.contributor.authorMetzler-Nolte, Nils
dc.contributor.authorSuman, Sigridur G
dc.contributor.departmentRaunvísindadeild (HÍ)en_US
dc.contributor.departmentFaculty of Physical Sciences (UI)en_US
dc.contributor.schoolVerkfræði- og náttúruvísindasvið (HÍ)en_US
dc.contributor.schoolSchool of Engineering and Natural Sciences (UI)en_US
dc.date.accessioned2020-08-10T13:13:31Z
dc.date.available2020-08-10T13:13:31Z
dc.date.issued2016-07
dc.descriptionPost-print (lokagerð höfundar)en_US
dc.description.abstractSelected molybdenum sulfur compounds with the formulas (M)[Mo2O2S4L] where (Et4N)2(1), L = S42 −, (Et4N)(2), L = Cp, (3), L = DMF, K(5), L = serine, M = Et4N+, K+, Na+ and [Mo2O2S2L2] where Na2(4), L = cysteine, and (6), L = threonine, were prepared and subjected to cytotoxicity studies in vitro. The results were analyzed to rank the compounds according to their relative cytotoxicity and to correlate the observed toxicity to specific composition. The results guide future efforts to synthesize highly water soluble, non-toxic, compounds. Strong correlation was observed between toxicity and cation selection, as well as selection of biocompatible ligands combined with alkali metal salts. The most toxic compound analyzed showed about 50 times less cytotoxicity than the cisplatin reference compound in HT-29 cells. Preliminary results from in vivo data agree with the ranking obtained in vitro.en_US
dc.description.sponsorshipJMG thanks for support by a STSM Grant by COST Action CM1105. Icelandic Centre for Research (Rannís) is thanked for financial support (grant 140945-052).en_US
dc.description.versionPeer revieweden_US
dc.format.extent166-171en_US
dc.identifier.citationGretarsdóttir, J. M., Bobersky, S., Metzler-Nolte, N., & Suman, S. G. (2016). Cytotoxicity studies of water soluble coordination compounds with a [Mo2O2S2]2+ core. Journal of Inorganic Biochemistry, 160, 166-171. doi:https://doi.org/10.1016/j.jinorgbio.2016.01.020en_US
dc.identifier.doi10.1016/j.jinorgbio.2016.01.020
dc.identifier.issn0162-0134
dc.identifier.journalJournal of Inorganic Biochemistryen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11815/1948
dc.language.isoenen_US
dc.publisherElsevier BVen_US
dc.relation.ispartofseriesJournal of Inorganic Biochemistry;160
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEiturefnafræðien_US
dc.subjectBrennisteinnen_US
dc.subjectCytotoxicityen_US
dc.subjectMolybdenumen_US
dc.subjectSulfuren_US
dc.titleCytotoxicity studies of water soluble coordination compounds with a [Mo 2 O 2 S 2 ] 2+ coreen_US
dc.typeinfo:eu-repo/semantics/articleen_US

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