Noncovalent and site-directed spin labeling of duplex RNA

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dc.contributorHáskóli Íslandsen_US
dc.contributorUniversity of Icelanden_US
dc.contributor.authorKamble, Nilesh Ramesh
dc.contributor.authorGränz, Markus
dc.contributor.authorPrisner, Thomas F.
dc.contributor.authorSigurdsson, Snorri
dc.contributor.departmentRaunvísindadeild (HÍ)en_US
dc.contributor.departmentFaculty of Physical Sciences (UI)en_US
dc.contributor.departmentRaunvísindastofnun (HÍ)en_US
dc.contributor.departmentScience Institute (UI)en_US
dc.contributor.schoolVerkfræði- og náttúruvísindasvið (HÍ)en_US
dc.contributor.schoolSchool of Engineering and Natural Sciences (UI)en_US
dc.date.accessioned2020-08-10T15:21:54Z
dc.date.available2020-08-10T15:21:54Z
dc.date.issued2016
dc.descriptionPost-print (lokagerð höfundar)en_US
dc.description.abstractAn isoindoline-nitroxide derivative of guanine (G, "G-spin") was shown to bind specifically and effectively to abasic sites in duplex RNAs. Distance measurements on a G-labeled duplex RNA with PELDOR (DEER) showed a strong orientation dependence. Thus, G is a readily synthesized, orientation-selective spin label for "mix and measure" PELDOR experiments.en_US
dc.description.sponsorshipThis work was supported by the Deutsche Forschungsgemeinschaft DFG (SFB 902 Molecular Principles of RNA-based Regulation), the Icelandic Research Fund (141062051) and by a doctoral fellowship to N. R. K. from the University of Iceland Research Fund. We thank Dr S. Jonsdottir for assistance in collecting analytical data for structural characterization of the compounds.en_US
dc.description.versionPeer revieweden_US
dc.format.extent14442-14445en_US
dc.identifier.doi10.1039/C6CC08387K
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X (eISSN)
dc.identifier.journalChemical Communicationsen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11815/1960
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistry (RSC)en_US
dc.relation.ispartofseriesChemical Communications;52(100)
dc.relation.urlhttp://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC08387Ken_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNicotinamide adenine dinucleotideen_US
dc.subjectElectron paramagnetic resonanceen_US
dc.subjectNucleic acid structureen_US
dc.subjectEPR spectroscopyen_US
dc.subjectIsoindoline nitroxidesen_US
dc.subjectAlcohol dehydrogenaseen_US
dc.subjectDistance measurementsen_US
dc.subjectAbasic sitesen_US
dc.subjectDNAen_US
dc.subjectDynamicsen_US
dc.subjectLitrófsgreiningen_US
dc.subjectKjarnsýruren_US
dc.subjectRafeindiren_US
dc.titleNoncovalent and site-directed spin labeling of duplex RNAen_US
dc.typeinfo:eu-repo/semantics/articleen_US

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