Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Almenn færsla
dc.contributorHáskóli Íslands (HÍ)en_US
dc.contributorUniversity of Iceland (UI)en_US
dc.contributor.authorDavies, Gail
dc.contributor.authorLam, Max
dc.contributor.authorHarris, Sarah E.
dc.contributor.authorTrampush, Joey W.
dc.contributor.authorLuciano, Michelle
dc.contributor.authorHill, W. David
dc.contributor.authorHagenaars, Saskia P.
dc.contributor.authorRitchie, Stuart J.
dc.contributor.authorMarioni, Riccardo E.
dc.contributor.authorFawns-Ritchie, Chloe
dc.contributor.authorLiewald, David C. M.
dc.contributor.authorOkely, Judith A.
dc.contributor.authorAhola-Olli, Ari V.
dc.contributor.authorBarnes, Catriona L. K.
dc.contributor.authorBertram, Lars
dc.contributor.authorBis, Joshua C.
dc.contributor.authorBurdick, Katherine E.
dc.contributor.authorChristoforou, Andrea
dc.contributor.authorDeRosse, Pamela
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorGiakoumaki, Stella
dc.contributor.authorGiddaluru, Sudheer
dc.contributor.authorGustavson, Daniel E.
dc.contributor.authorHayward, Caroline
dc.contributor.authorHofer, Edith
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorKarlsson, Robert
dc.contributor.authorKnowles, Emma
dc.contributor.authorLahti, Jari
dc.contributor.authorLeber, Markus
dc.contributor.authorLi, Shuo
dc.contributor.authorMather, Karen A.
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMorris, Derek
dc.contributor.authorOldmeadow, Christopher
dc.contributor.authorPalviainen, Teemu
dc.contributor.authorPayton, Antony
dc.contributor.authorPazoki, Raha
dc.contributor.authorPetrovic, Katja
dc.contributor.authorReynolds, Chandra A.
dc.contributor.authorSargurupremraj, Muralidharan
dc.contributor.authorScholz, Markus
dc.contributor.authorSmith, Jennifer A.
dc.contributor.authorSmith, Albert Vernon
dc.contributor.authorTerzikhan, Natalie
dc.contributor.authorThalamuthu, Anbupalam
dc.contributor.authorTrompet, Stella
dc.contributor.authorvan der Lee, Sven J.
dc.contributor.authorWare, Erin B.
dc.contributor.authorWindham, B. Gwen
dc.contributor.authorWright, Margaret J.
dc.contributor.authorYang, Jingyun
dc.contributor.authorYu, Jin
dc.contributor.authorAmes, David
dc.contributor.authorAmin, Najaf
dc.contributor.authorAmouyel, Philippe
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorArmstrong, Nicola J.
dc.contributor.authorAssareh, Amelia A.
dc.contributor.authorAttia, John R.
dc.contributor.authorAttix, Deborah
dc.contributor.authorAvramopoulos, Dimitrios
dc.contributor.authorBennett, David A.
dc.contributor.authorBöhmer, Anne C.
dc.contributor.authorBoyle, Patricia A.
dc.contributor.authorBrodaty, Henry
dc.contributor.authorCampbell, Harry
dc.contributor.authorCannon, Tyrone D.
dc.contributor.authorCirulli, Elizabeth T.
dc.contributor.authorCongdon, Eliza
dc.contributor.authorConley, Emily Drabant
dc.contributor.authorCorley, Janie
dc.contributor.authorCox, Simon R.
dc.contributor.authorDale, Anders M.
dc.contributor.authorDehghan, Abbas
dc.contributor.authorDick, Danielle
dc.contributor.authorDickinson, Dwight
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorEvangelou, Evangelos
dc.contributor.authorFaul, Jessica D.
dc.contributor.authorFord, Ian
dc.contributor.authorFreimer, Nelson A.
dc.contributor.authorGao, He
dc.contributor.authorGiegling, Ina
dc.contributor.authorGillespie, Nathan A.
dc.contributor.authorGordon, Scott D.
dc.contributor.authorGottesman, Rebecca F.
dc.contributor.authorGriswold, Michael E.
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorHartmann, Annette M.
dc.contributor.authorHatzimanolis, Alex
dc.contributor.authorHeiss, Gerardo
dc.contributor.authorHolliday, Elizabeth G.
dc.contributor.authorJoshi, Peter K.
dc.contributor.authorKähönen, Mika
dc.contributor.authorKardia, Sharon L. R.
dc.contributor.authorKarlsson, Ida
dc.contributor.authorKleineidam, Luca
dc.contributor.authorKnopman, David S.
dc.contributor.authorKochan, Nicole A.
dc.contributor.authorKonte, Bettina
dc.contributor.authorKwok, John B.
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorLee, Teresa
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorLi, Shu-Chen
dc.contributor.authorLill, Christina M.
dc.contributor.authorLiu, Tian
dc.contributor.authorKoini, Marisa
dc.contributor.authorLondon, Edythe
dc.contributor.authorLongstreth, Will T.
dc.contributor.authorLopez, Oscar L.
dc.contributor.authorLoukola, Anu
dc.contributor.authorLuck, Tobias
dc.contributor.authorLundervold, Astri J.
dc.contributor.authorLundquist, Anders
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorMurray, Alison D.
dc.contributor.authorNeed, Anna C.
dc.contributor.authorNoordam, Raymond
dc.contributor.authorNyberg, Lars
dc.contributor.authorOllier, William
dc.contributor.authorPapenberg, Goran
dc.contributor.authorPattie, Alison
dc.contributor.authorPolasek, Ozren
dc.contributor.authorPoldrack, Russell A.
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorReppermund, Simone
dc.contributor.authorRiedel-Heller, Steffi G.
dc.contributor.authorRose, Richard J.
dc.contributor.authorRotter, Jerome I.
dc.contributor.authorRoussos, Panos
dc.contributor.authorRovio, Suvi P.
dc.contributor.authorSaba, Yasaman
dc.contributor.authorSabb, Fred W.
dc.contributor.authorSachdev, Perminder S.
dc.contributor.authorSatizabal, Claudia L.
dc.contributor.authorSchmid, Matthias
dc.contributor.authorScott, Rodney J.
dc.contributor.authorScult, Matthew A.
dc.contributor.authorSimino, Jeannette
dc.contributor.authorSlagboom, P. Eline
dc.contributor.authorSmyrnis, Nikolaos
dc.contributor.authorSoumaré, Aïcha
dc.contributor.authorStefanis, Nikos C.
dc.contributor.authorStott, David J.
dc.contributor.authorStraub, Richard E.
dc.contributor.authorSundet, Kjetil
dc.contributor.authorTaylor, Adele M.
dc.contributor.authorTaylor, Kent D.
dc.contributor.authorTzoulaki, Ioanna
dc.contributor.authorTzourio, Christophe
dc.contributor.authorUitterlinden, André
dc.contributor.authorVitart, Veronique
dc.contributor.authorVoineskos, Aristotle N.
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorWagner, Michael
dc.contributor.authorWagner, Holger
dc.contributor.authorWeinhold, Leonie
dc.contributor.authorWen, K. Hoyan
dc.contributor.authorWiden, Elisabeth
dc.contributor.authorYang, Qiong
dc.contributor.authorZhao, Wei
dc.contributor.authorAdams, Hieab H. H.
dc.contributor.authorArking, Dan E.
dc.contributor.authorBilder, Robert M.
dc.contributor.authorBitsios, Panos
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorChiba-Falek, Ornit
dc.contributor.authorCorvin, Aiden
dc.contributor.authorDe Jager, Philip L.
dc.contributor.authorDebette, Stéphanie
dc.contributor.authorDonohoe, Gary
dc.contributor.authorElliott, Paul
dc.contributor.authorFitzpatrick, Annette L.
dc.contributor.authorGill, Michael
dc.contributor.authorGlahn, David C.
dc.contributor.authorHägg, Sara
dc.contributor.authorHansell, Narelle K.
dc.contributor.authorHariri, Ahmad R.
dc.contributor.authorIkram, M. Kamran
dc.contributor.authorJukema, J. Wouter
dc.contributor.authorVuoksimaa, Eero
dc.contributor.authorKeller, Matthew C.
dc.contributor.authorKremen, William S.
dc.contributor.authorLauner, Lenore
dc.contributor.authorLindenberger, Ulman
dc.contributor.authorPalotie, Aarno
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorPendleton, Neil
dc.contributor.authorPorteous, David J.
dc.contributor.authorRäikkönen, Katri
dc.contributor.authorRaitakari, Olli T.
dc.contributor.authorRamirez, Alfredo
dc.contributor.authorReinvang, Ivar
dc.contributor.authorRudan, Igor
dc.contributor.departmentLæknadeild (HÍ)en_US
dc.contributor.departmentFaculty of Medicine (UI)en_US
dc.contributor.schoolHeilbrigðisvísindasvið (HÍ)en_US
dc.contributor.schoolSchool of Health Sciences (UI)en_US
dc.date.accessioned2019-12-16T13:07:56Z
dc.date.available2019-12-16T13:07:56Z
dc.date.issued2018-05-29
dc.descriptionPublisher's version (útgefin grein)en_US
dc.description.abstractGeneral cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.en_US
dc.description.sponsorshipThis research was conducted in The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council (MR/K026992/1). This research was conducted using the UK Biobank Resource (Application Nos. 10279 and 4844). The Neurology Working Group within the Cohorts for Heart and Aging Research in Genomic Epidemiology is partly supported by grants from the National Institute on Aging (R01 AG033193, U01 AG049505 and U01 AG052409). Cohort-specific acknowledgements are in Supplementary Note 3.en_US
dc.description.versionPeer Revieweden_US
dc.format.extent2098en_US
dc.identifier.citationDavies, G., Lam, M., Harris, S.E. et al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun 9, 2098 (2018) doi:10.1038/s41467-018-04362-xen_US
dc.identifier.doi10.1038/s41467-018-04362-x
dc.identifier.issn2041-1723
dc.identifier.journalNature Communicationsen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11815/1394
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofseriesNature Communications;9(1)
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCognitive neuroscienceen_US
dc.subjectGenetics of the nervous systemen_US
dc.subjectGenome-wide association studiesen_US
dc.subjectQuantitative traiten_US
dc.subjectTaugavísindien_US
dc.subjectErfðafræðien_US
dc.subjectRannsókniren_US
dc.subjectHeilinnen_US
dc.titleStudy of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive functionen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dcterms.licenseOpen Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US

Skrár

Original bundle

Niðurstöður 1 - 1 af 1
Thumbnail Image
Nafn:
s41467-018-04362-x.pdf
Stærð:
3.14 MB
Snið:
Adobe Portable Document Format
Description:
Publisher´s version
Hlaða niður

Undirflokkur

Greinar- HÍ

Öll gögn í Opnum vísindum eru vernduð af ákvæðum höfundalaga og með öllum réttindum áskildum, nema annað sé tekið fram.