Rational vaccine design in times of emerging diseases : The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation

Almenn færsla
dc.contributor.authorSchijns, Virgil
dc.contributor.authorMajhen, Dragomira
dc.contributor.authorVan Der Ley, Peter
dc.contributor.authorThakur, Aneesh
dc.contributor.authorSummerfield, Artur
dc.contributor.authorBerisio, Rita
dc.contributor.authorNativi, Cristina
dc.contributor.authorFernández-Tejada, Alberto
dc.contributor.authorÁlverez-Dominguez, Carmen
dc.contributor.authorGizurarson, Sveinbjörn
dc.contributor.authorZamyatina, Alla
dc.contributor.authorMolinaro, Antonio
dc.contributor.authorRosano, Camillo
dc.contributor.authorJakopin, Žiga
dc.contributor.authorGursel, Ihsan
dc.contributor.authorMcClean, Siobhán
dc.contributor.departmentFaculty of Pharmaceutical Sciences
dc.date.accessioned2025-11-20T08:27:52Z
dc.date.available2025-11-20T08:27:52Z
dc.date.issued2021-04-06
dc.descriptionunding text Funding: This review was supported by Horizon 2020 EU COST Action CA16231 European Network of Vaccine Adjuvants. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.description.abstractVaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their efficacy, by tailoring the immune response. Establishing the immune correlates of protection greatly informs the rational design of vaccines. This facilitates the selection of the best vaccine antigens and the most appropriate vaccine adjuvant to generate optimal memory immune T cell and B cell responses. This review outlines the range of vaccine types that are currently authorised and those under development. We outline the optimal immunological correlates of protection that can be targeted. Finally we review approaches to rational antigen selection and rational vaccine adjuvant design. Harnessing current knowledge on protective immune responses in combination with critical vaccine components is imperative to the prevention of future life-threatening diseases.en
dc.description.versionPeer revieweden
dc.format.extent2578369
dc.format.extent
dc.identifier.citationSchijns, V, Majhen, D, Van Der Ley, P, Thakur, A, Summerfield, A, Berisio, R, Nativi, C, Fernández-Tejada, A, Álverez-Dominguez, C, Gizurarson, S, Zamyatina, A, Molinaro, A, Rosano, C, Jakopin, Ž, Gursel, I & McClean, S 2021, 'Rational vaccine design in times of emerging diseases : The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation', Pharmaceutics, vol. 13, no. 4, 501. https://doi.org/10.3390/pharmaceutics13040501en
dc.identifier.doi10.3390/pharmaceutics13040501
dc.identifier.issn1999-4923
dc.identifier.other39539845
dc.identifier.othera370a87f-9cb9-4906-9625-6e937a4ebd98
dc.identifier.other85105163633
dc.identifier.other33917629
dc.identifier.other000643507100001
dc.identifier.otherunpaywall: 10.3390/pharmaceutics13040501
dc.identifier.urihttps://hdl.handle.net/20.500.11815/6414
dc.language.isoen
dc.relation.ispartofseriesPharmaceutics; 13(4)en
dc.relation.urlhttps://www.scopus.com/pages/publications/85105163633en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectAdjuvanten
dc.subjectAntigenen
dc.subjectDelivery systemen
dc.subjectDesignen
dc.subjectImmunizationen
dc.subjectRationalen
dc.subjectRouteen
dc.subjectVaccineen
dc.subjectPharmaceutical Scienceen
dc.titleRational vaccine design in times of emerging diseases : The critical choices of immunological correlates of protection, vaccine antigen and immunomodulationen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreviewen

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