Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

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dc.contributor.authorVan Zuydam, Natalie R.
dc.contributor.authorLadenvall, Claes
dc.contributor.authorVoight, Benjamin F.
dc.contributor.authorStrawbridge, Rona J.
dc.contributor.authorFernandez-Tajes, Juan
dc.contributor.authorRayner, N. William
dc.contributor.authorRobertson, Neil R.
dc.contributor.authorMahajan, Anubha
dc.contributor.authorVlachopoulou, Efthymia
dc.contributor.authorGoel, Anuj
dc.contributor.authorKleber, Marcus E.
dc.contributor.authorNelson, Christopher P.
dc.contributor.authorKwee, Lydia Coulter
dc.contributor.authorEsko, Tõnu
dc.contributor.authorMihailov, Evelin
dc.contributor.authorMägi, Reedik
dc.contributor.authorMilani, Lili
dc.contributor.authorFischer, Krista
dc.contributor.authorKanoni, Stavroula
dc.contributor.authorKumar, Jitender
dc.contributor.authorSong, Ci
dc.contributor.authorHartiala, Jaana A.
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorPerola, Markus
dc.contributor.authorGieger, Christian
dc.contributor.authorPeters, Annette
dc.contributor.authorQu, Liming
dc.contributor.authorWillems, Sara M.
dc.contributor.authorDoney, Alex S.F.
dc.contributor.authorMorris, Andrew D.
dc.contributor.authorZheng, Yan
dc.contributor.authorSesti, Giorgio
dc.contributor.authorHu, Frank B.
dc.contributor.authorQi, Lu
dc.contributor.authorLaakso, Markku
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorGrallert, Harald
dc.contributor.authorVan Duijn, Cornelia
dc.contributor.authorReilly, Muredach P.
dc.contributor.authorIngelsson, Erik
dc.contributor.authorDeloukas, Panos
dc.contributor.authorKathiresan, Sek
dc.contributor.authorMetspalu, Andres
dc.contributor.authorShah, Svati H.
dc.contributor.authorSinisalo, Juha
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorHamsten, Anders
dc.contributor.authorSamani, Nilesh J.
dc.contributor.authorMärz, Winfried
dc.contributor.authorHazen, Stanley L.
dc.contributor.schoolHealth Sciences
dc.date.accessioned2025-11-20T09:02:37Z
dc.date.available2025-11-20T09:02:37Z
dc.date.issued2020-12-01
dc.descriptionThis work was supported by the European Union Framework Programme 7 (FP7/2007-2013) for the Innovative Medicine Initiative (IMI) under grant agreement n° IMI/115006 (the SUMMIT [Surrogate Markers for Micro- and Macro-Vascular Hard End Points for Innovative Diabetes Tools] consortium); Aarno Koskelo Foundation; Academy of Finland (no. 263401; no. 2676882); American Heart Association (13SDG14330006); AstraZeneca; AtheroSysMed (Systems medicine of coronary heart disease and stroke); British Heart Foundation Centre of Research Excellence at Oxford; ERC269045-Gene Target T2D grant; Estonian Research Council (IUT20-60, PUT1660 and PUT1665P); Estonian Center of Genomics/Roadmap II (project No. 2014-2020.4.01.16-0125); European Union (no. 692145; no. 633589; no. 313010; LSHM-CT-2007-037273; no. 201668; 2014-2020.4.01.15-0012;QLG1-CT-2002-00896; EU/QLRT-2001-01254; QLG2-CT-2002-01254 HEALTH-F2-2013-601456); Finnish Foundation for Cardiovascular research; Gentransmed - Centre of Excellence for Genomics and Translational Medicine; German Ministry of Education and Research (no. 01ZX1313A-K); Helsinki University Central Hospital special government funds (TYH7215, TKK2012005, TYH2012209, TYH2014312); Juvenile Diabetes Research Foundation (JDRF, 2-SRA-2014-276-Q-R); National Institute of Diabetes and Digestive and Kidney diseases (NIDDK, 5R01DK106236; U01-DK066134; U01-DK105535; R01DK101478); National Heart, Lung and Blood Institute (NLHBI, R01HL103866); National Institute for Health Research (NIHR); Personalized diagnostics and treatment of high risk coronary artery disease patients (RiskyCAD; 305739); Sigrid Juselius Foundation; Finnish Academy (no. 269517); Finnish Foundation for Cardiovascular Research; Foundation for Strategic Research and Stockholm County Council (560283; 592229); Juho Vainio Foundation; Knut and Alice Wallenberg Foundation; Ministry for Higher Education; Strategic Cardiovascular and Diabetes Programmes of Karolinska Institutet and Stockholm County Council; Swedish Foundation for Strategic Research (SSF; ICA08-0047); Swedish Heart-Lung Foundation; Swedish Research Council (project 8691; 2015-02558; 2016-00598; M-2005-1112 and 2009-2298); Torsten and Ragnar Söderberg Foundation; W.W. Smith Charitable Trust (H1201); Wellcome Trust Institutional strategic support fund; Yrjö Jahnsson Foundation. Publisher Copyright: © 2020 Lippincott Williams and Wilkins. All rights reserved.en
dc.description.abstractBackground: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). Results: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. Conclusions: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.en
dc.description.versionPeer revieweden
dc.format.extent1659446
dc.format.extentE002769
dc.identifier.citationVan Zuydam, N R, Ladenvall, C, Voight, B F, Strawbridge, R J, Fernandez-Tajes, J, Rayner, N W, Robertson, N R, Mahajan, A, Vlachopoulou, E, Goel, A, Kleber, M E, Nelson, C P, Kwee, L C, Esko, T, Mihailov, E, Mägi, R, Milani, L, Fischer, K, Kanoni, S, Kumar, J, Song, C, Hartiala, J A, Pedersen, N L, Perola, M, Gieger, C, Peters, A, Qu, L, Willems, S M, Doney, A S F, Morris, A D, Zheng, Y, Sesti, G, Hu, F B, Qi, L, Laakso, M, Thorsteinsdottir, U, Grallert, H, Van Duijn, C, Reilly, M P, Ingelsson, E, Deloukas, P, Kathiresan, S, Metspalu, A, Shah, S H, Sinisalo, J, Salomaa, V, Hamsten, A, Samani, N J, März, W & Hazen, S L 2020, 'Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus', Circulation: Genomic and Precision Medicine, vol. 13, no. 6, pp. E002769. https://doi.org/10.1161/CIRCGEN.119.002769en
dc.identifier.doi10.1161/CIRCGEN.119.002769
dc.identifier.issn1942-325X
dc.identifier.other69288467
dc.identifier.othercdbfd4d3-dd54-48d8-b18e-3d28610e867c
dc.identifier.other85097959733
dc.identifier.other33321069
dc.identifier.urihttps://hdl.handle.net/20.500.11815/7000
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/115006
dc.relation.ispartofseriesCirculation: Genomic and Precision Medicine; 13(6)en
dc.relation.urlhttps://www.scopus.com/pages/publications/85097959733en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectblood pressureen
dc.subjectcoronary artery diseaseen
dc.subjectdiabetes mellitusen
dc.subjectgenome-wide association studyen
dc.subjectrisk factorsen
dc.subjectGeneticsen
dc.subjectCardiology and Cardiovascular Medicineen
dc.subjectGenetics (clinical)en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleGenetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitusen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/articleen

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