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Patterns of homozygosity in insular and continental goat breeds

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dc.contributor Landbúnaðarháskóli Íslands
dc.contributor Agricultural University of Iceland
dc.contributor.author Figueiredo Cardoso, Tainã
dc.contributor.author Amills, Marcel
dc.contributor.author Bertolini, Francesca
dc.contributor.author Rothschild, Max F.
dc.contributor.author Marras, Gabriele
dc.contributor.author Boink, Geert
dc.contributor.author Jordana, Jordi
dc.contributor.author Capote, Juan
dc.contributor.author Carolan, Sean
dc.contributor.author Hallsson, Jon
dc.contributor.author Kantanen, Juha
dc.contributor.author Pons, Àgueda L.
dc.contributor.author Lenstra, Johannes A.
dc.date.accessioned 2019-01-15T11:49:51Z
dc.date.available 2019-01-15T11:49:51Z
dc.date.issued 2018-11-19
dc.identifier.citation Cardoso, T. F., Amills, M., Bertolini, F., Rothschild, M., Marras, G., Boink, G., ... & Kantanen, J. (2018). Patterns of homozygosity in insular and continental goat breeds. Genetics Selection Evolution, 50(1), 56.
dc.identifier.issn 1297-9686
dc.identifier.uri https://hdl.handle.net/20.500.11815/978
dc.description.abstract Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 individuals from 25 European and African breeds with the Goat SNP50 BeadChip and comparing patterns of homozygosity of insular and nearby continental breeds. Results: Among the breeds analysed, number and total length of ROH varied considerably and depending on breeds, ROH could cover a substantial fraction of the genome (up to 1.6 Gb in Icelandic goats). When compared with their continental counterparts, goats from Iceland, Madagascar, La Palma and Ireland (Bilberry and Arran) displayed a significant increase in ROH coverage, ROH number and F ROH values (P value < 0.05). Goats from Mediterranean islands represent a more complex case because certain populations displayed a significantly increased level of homozygosity (e.g. Girgentana) and others did not (e.g. Corse and Sarda). Correlations of number and total length of ROH for insular goat populations with the distance between islands and the nearest continental locations revealed an effect of extremely long distances on the patterns of homozygosity. Conclusions: These results indicate that the effects of insularization on the patterns of homozygosity are variable. Goats raised in Madagascar, Iceland, Ireland (Bilberry and Arran) and La Palma, show high levels of homozygosity, whereas those bred in Mediterranean islands display patterns of homozygosity that are similar to those found in continental populations. These results indicate that the diversity of insular goat populations is modulated by multiple factors such as geographic distribution, population size, demographic history, trading and breed management. © 2018 The Author(s).
dc.description.sponsorship We acknowledge financial support from the Spanish Ministry of Economy and Competitiveness (Project AGL2016‑76108‑R), the “Severo Ochoa Programme for Centres of Excellence in R&D”2016‑2019 (SEV‑2015‑0533), the CERCA Programme/Generalitat de Catalunya and the Dutch Stichting Zeldzame Huisdierrassen. Funding for FB and MR were provided by the Ensminger endowment, Hatch and State of Iowa funds. Tainã F Cardoso was funded with a fellowship from the CAPES Foundation‑Coordination of Improvement of Higher Education, Ministry of Education (MEC) of the Federal Government of Brazil.
dc.format.extent 50(56)
dc.language.iso en
dc.publisher Springer Nature America, Inc
dc.relation.ispartofseries Genetics Selection Evolution;50(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Animal Science and Zoology
dc.subject Genetics
dc.subject General Medicine
dc.subject Erfðafræði
dc.subject Kvikfjárrækt
dc.subject Geitur
dc.title Patterns of homozygosity in insular and continental goat breeds
dc.type info:eu-repo/semantics/article
dc.description.version Peer Reviewed
dc.identifier.journal Genetics Selection Evolution
dc.identifier.doi 10.1186/s12711-018-0425-7
dc.relation.url http://link.springer.com/content/pdf/10.1186/s12711-018-0425-7.pdf
dc.contributor.department Auðlinda- og umhverfisdeild (LBHÍ)
dc.contributor.department Faculty of Natural Resources and Environmental Sciences (AUI)

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