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Asthma and COPD overlap (ACO) is related to a high burden of sleep disturbance and respiratory symptoms: Results from the RHINE and Swedish GA2LEN surveys

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Mindus, Stephanie
dc.contributor.author Malinovschi, Andrei
dc.contributor.author Ekerljung, Linda
dc.contributor.author Forsberg, Bertil
dc.contributor.author Gislason, Thorarinn
dc.contributor.author Jõgi, Rain
dc.contributor.author Franklin, Karl A.
dc.contributor.author Holm, Mathias
dc.contributor.author Johannessen, Ane
dc.contributor.author Middelveld, Roelinde
dc.contributor.author Schlünssen, Vivi
dc.contributor.author Svanes, Cecilie
dc.contributor.author Torén, Kjell
dc.contributor.author Lindberg, Eva
dc.contributor.author Janson, Christer
dc.date.accessioned 2019-01-14T10:24:31Z
dc.date.available 2019-01-14T10:24:31Z
dc.date.issued 2018-04-02
dc.identifier.citation Mindus, S., Malinovschi, A., Ekerljung, L., Forsberg, B., Gíslason, T., Jõgi, R., . . . Janson, C. (2018). Asthma and COPD overlap (ACO) is related to a high burden of sleep disturbance and respiratory symptoms: Results from the RHINE and Swedish GA2LEN surveys. PLoS One, 13(4), e0195055. doi:10.1371/journal.pone.0195055
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/20.500.11815/971
dc.description Publisher's version (útgefin grein)
dc.description.abstract Background The term Asthma and COPD Overlap (ACO) describes a condition where asthma and COPD overlap. We aimed to investigate associations between ACO and insomnia and respiratory symptoms, and to investigate the prevalence of ACO and the characteristics of subjects with ACO in two Northern European population studies. Methods The study comprised 25 429 subjects aged ≥ 40 years who participated in one of two Northern European general population surveys. Both surveys included questions on asthma, COPD, respiratory and sleep-related symptoms, including difficulty initiating sleep, difficulty maintaining sleep, early-morning awakening, and excessive daytime sleepiness. ACO was defined as having both self-reported asthma and COPD. Results The prevalence of ACO was 1.0%. The group with ACO had a higher prevalence of both insomnia and respiratory symptoms than subjects with only asthma or COPD. Having ACO was independently associated with a 2–3 times higher probability of having sleep-related symptoms as compared with the group without asthma or COPD, after adjustment for age, sex, BMI, smoking history and educational level (adjusted odds ratio 2.14–3.36, 95% CI). Conclusion Subjects with ACO have a high prevalence of insomnia and respiratory symptoms. To our knowledge, this is the first study to assess the association between sleep-related symptoms and ACO.
dc.description.sponsorship The GA2LEN survey was financially supported by the EU Sixth Framework Programme for Research, contract no. FOOD-CT-2004-506378. The study was also financially supported by the Swedish Heart and Lung Foundation, the Swedish Asthma and Allergy Foundation and the Swedish Association against Heart and Lung Diseases. The Gothenburg part of the study was mainly funded by the VBG Group Centre for Asthma and Allergy Research. The RHINE study was funded by the Swedish Heart and Lung Foundation, the Swedish Association Against Asthma and Allergy, the Swedish Association against Heart and Lung Disease, the Swedish Council for Working Life and Social Research, the Bror Hjerpstedt Foundation, the Vårdal Foundation for Health Care and Allergic Research, the Faculty of. Health, Aarhus University, Denmark (Project No. 240008), the Wood Dust Foundation (Project No 444508795), the Danish Lung Association, the Norwegian Research Council (project 135773/330), the Norwegian Asthma and Allergy Association, the Icelandic Research Council and the Estonian Science Foundation (Grant No. 4350).
dc.format.extent e0195055
dc.language.iso en
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartofseries Plos One;13(4)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Chronic obstructive pulmonary disease
dc.subject Sleep
dc.subject Asthma
dc.subject Insomnia
dc.subject Educational attainment
dc.subject Europe
dc.subject Spirometry
dc.subject Bronchitis
dc.subject Öndunarfærasjúkdómar
dc.subject Berkjubólga
dc.subject Astmi
dc.subject Svefn
dc.subject Svefnleysi
dc.title Asthma and COPD overlap (ACO) is related to a high burden of sleep disturbance and respiratory symptoms: Results from the RHINE and Swedish GA2LEN surveys
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.version Peer Reviewed
dc.identifier.journal Plos One
dc.identifier.doi 10.1371/journal.pone.0195055
dc.relation.url http://dx.plos.org/10.1371/journal.pone.0195055
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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