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Asthma and COPD overlap (ACO) is related to a high burden of sleep disturbance and respiratory symptoms: Results from the RHINE and Swedish GA2LEN surveys

Asthma and COPD overlap (ACO) is related to a high burden of sleep disturbance and respiratory symptoms: Results from the RHINE and Swedish GA2LEN surveys


Title: Asthma and COPD overlap (ACO) is related to a high burden of sleep disturbance and respiratory symptoms: Results from the RHINE and Swedish GA2LEN surveys
Author: Mindus, Stephanie
Malinovschi, Andrei
Ekerljung, Linda
Forsberg, Bertil
Gíslason, Þórarinn
Jõgi, Rain
Franklin, Karl A.
Holm, Mathias
Johannessen, Ane
Middelveld, Roelinde
... 5 more authors Show all authors
Date: 2018-04-02
Language: English
Scope: e0195055
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Læknadeild (HÍ)
Faculty of Medicine (UI)
Series: Plos One;13(4)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0195055
Subject: Chronic obstructive pulmonary disease; Sleep; Asthma; Insomnia; Educational attainment; Europe; Spirometry; Bronchitis; Öndunarfærasjúkdómar; Berkjubólga; Astmi; Svefn; Svefnleysi
URI: https://hdl.handle.net/20.500.11815/971

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Citation:

Mindus, S., Malinovschi, A., Ekerljung, L., Forsberg, B., Gíslason, T., Jõgi, R., . . . Janson, C. (2018). Asthma and COPD overlap (ACO) is related to a high burden of sleep disturbance and respiratory symptoms: Results from the RHINE and Swedish GA2LEN surveys. PLoS One, 13(4), e0195055. doi:10.1371/journal.pone.0195055

Abstract:

Background The term Asthma and COPD Overlap (ACO) describes a condition where asthma and COPD overlap. We aimed to investigate associations between ACO and insomnia and respiratory symptoms, and to investigate the prevalence of ACO and the characteristics of subjects with ACO in two Northern European population studies. Methods The study comprised 25 429 subjects aged ≥ 40 years who participated in one of two Northern European general population surveys. Both surveys included questions on asthma, COPD, respiratory and sleep-related symptoms, including difficulty initiating sleep, difficulty maintaining sleep, early-morning awakening, and excessive daytime sleepiness. ACO was defined as having both self-reported asthma and COPD. Results The prevalence of ACO was 1.0%. The group with ACO had a higher prevalence of both insomnia and respiratory symptoms than subjects with only asthma or COPD. Having ACO was independently associated with a 2–3 times higher probability of having sleep-related symptoms as compared with the group without asthma or COPD, after adjustment for age, sex, BMI, smoking history and educational level (adjusted odds ratio 2.14–3.36, 95% CI). Conclusion Subjects with ACO have a high prevalence of insomnia and respiratory symptoms. To our knowledge, this is the first study to assess the association between sleep-related symptoms and ACO.

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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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