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Not so bad: avoidance and aversive discounting modulate threat appraisal in anterior cingulate and medial prefrontal cortex

Not so bad: avoidance and aversive discounting modulate threat appraisal in anterior cingulate and medial prefrontal cortex


Title: Not so bad: avoidance and aversive discounting modulate threat appraisal in anterior cingulate and medial prefrontal cortex
Author: Schlund, Michael W.
Brewer, Adam T.
Richman, David M.
Magee, Sandy K.
Dymond, Simon   orcid.org/0000-0003-1319-4492
Date: 2015-06-10
Language: English
Scope: 142
University/Institute: Háskólinn í Reykjavík (HR)
Reykjavík University (RU)
School: Viðskiptadeild (HR)
School of Business (RU)
Department: Sálfræði (HR)
Psychology (RU)
Series: Frontiers in Behavioral Neuroscience;9
ISSN: 1662-5153
DOI: 10.3389/fnbeh.2015.00142
Subject: Avoidance; Threat; Fear; Anterior cingulate; Medial prefrontal cortex; Loss discounting; Anxiety; Neuroimaging; Kvíði; Ótti; Sálfræði; Heilinn
URI: https://hdl.handle.net/20.500.11815/927

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Citation:

Schlund, M. W., Brewer, A. T., Richman, D. M., Magee, S. K., & Dymond, S. (2015). Not so bad: avoidance and aversive discounting modulate threat appraisal in anterior cingulate and medial prefrontal cortex. Frontiers in Behavioral Neuroscience, 9. https://doi.org/10.3389/fnbeh.2015.00142

Abstract:

The dorsal anterior cingulate (adACC) and dorsal medial prefrontal cortex (dmPFC) play a central role in the discrimination and appraisal of threatening stimuli. Yet, little is known about what specific features of threatening situations recruit these regions and how avoidance may modulate appraisal and activation through prevention of aversive events. In this investigation, 30 healthy adults underwent functional neuroimaging while completing an avoidance task in which responses to an Avoidable CS+ threat prevented delivery of an aversive stimulus, but not to an Unavoidable CS+ threat. Extinction testing was also completed where CSs were presented without aversive stimulus delivery and an opportunity to avoid. The Avoidable CS+ relative to the Unavoidable CS+ was associated with reductions in ratings of negative valence, fear, and US expectancy and activation. Greater regional activation was consistently observed to the Unavoidable CS+ during avoidance, which declined during extinction. Individuals exhibiting greater aversive discounting—that is, those more avoidant of immediate monetary loss compared to a larger delayed loss—also displayed greater activation to the Unavoidable CS+, highlighting aversive discounting as a significant individual difference variable. These are the first results linking adACC/dmPFC reactivity to avoidance-based reductions of aversive events and modulation of activation by individual differences in aversive discounting.

Rights:

Copyright © 2015 Schlund, Brewer, Richman, Magee and Dymond. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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