Fletta eftir titli tímarits "Organic Process Research and Development"

Atriði 1-1 af 1

Preparative Synthesis of an RP-Guanosine-3′,5′-Cyclic Phosphorothioate Analogue, a Drug Candidate for the Treatment of Retinal Degenerations

Pérez, Oswaldo; Schipper, Nicolaas; Bollmark, Martin (American Chemical Society, 2021-10-19)

Cyclic guanosine monophosphorothioate analogue 1a is currently showing potential as a drug for the treatment of inherited retinal neurodegenerations. To support ongoing preclinical and clinical work, we have developed a diastereoselective synthesis via ...